Predictability Of Quantification Of Beta-trace Protein For Diagnosis Of Cerebrospinal Fluid Leak: Cutoff Determination In Nasal Fluids With Two Control Groups

dc.creatorSampaio M.H.
dc.creatorDe Barros-Mazon S.
dc.creatorSakano E.
dc.creatorChone C.T.
dc.date2009
dc.date2015-06-26T13:33:32Z
dc.date2015-11-26T15:32:52Z
dc.date2015-06-26T13:33:32Z
dc.date2015-11-26T15:32:52Z
dc.date.accessioned2018-03-28T22:41:22Z
dc.date.available2018-03-28T22:41:22Z
dc.identifier
dc.identifierAmerican Journal Of Rhinology And Allergy. , v. 23, n. 6, p. 585 - 590, 2009.
dc.identifier19458924
dc.identifier10.2500/ajra.2009.23.3409
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-76149136709&partnerID=40&md5=78a3e1dccf29037f45a75199bf59632e
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/91743
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/91743
dc.identifier2-s2.0-76149136709
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1262591
dc.descriptionBackground: Cerebrospinal fluid (CSF) leak of the anterior skull base is an abnormal communication between the subarachnoid space and the nasal cavity or the paranasal sinus. Its presence increases the incidence of complications, as meningitis, with risk of sequelae. The early and correct diagnosis of the CSF leaks is important to perform surgical treatment as soon as possible. The CSF detection in nasal fluids could be made through the beta2-transferrin (beta2Tr) immunoelectrophoretic test, an expensive and cumbersome immunologic test, not available to the majority of the Brazilian hospitals. Recently, the detection of beta-trace protein (betaTP) for identification of CSF leaks has been described. The literature suggests there may be similar sensitivity and specificity to tests of beta2Tr, because betaTP is also a specific brain protein and it is present in CSF in high concentrations. The majority of Brazilian hospitals have the nephelometric equipment for betaTP detection. This study was designed to determine threshold values for betaTP concentrations in nasal cavity secretions as a predictor of CFS leak. Methods: Nasal secretions were collected from patients with suspicion of CSF leak and from healthy volunteers. Pure CSF samples were used. A nephelometric assay was used to determine the betaTP concentration in samples. Results: Values between 0.244 and 0.496 mg/L were determined for the cutoff. Conclusion: Beta-trace concentrations above 0.496 mg/L are highly suggestive of the presence of CSF in examined nasal secretion. Positive predictive value and negative predictive value were 100%. BetaTP nephelometric test can predict the side of the CSF leak. Copyright © 2009, OceanSide Publications, Inc.
dc.description23
dc.description6
dc.description585
dc.description590
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dc.languageen
dc.publisher
dc.relationAmerican Journal of Rhinology and Allergy
dc.rightsfechado
dc.sourceScopus
dc.titlePredictability Of Quantification Of Beta-trace Protein For Diagnosis Of Cerebrospinal Fluid Leak: Cutoff Determination In Nasal Fluids With Two Control Groups
dc.typeArtículos de revistas


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