Calcium And The Mechanotransduction In Cardiac Myocytes

dc.creatorJudice C.C.
dc.creatorMarin T.M.
dc.creatorFranchini K.G.
dc.date2009
dc.date2015-06-26T13:33:32Z
dc.date2015-11-26T15:32:45Z
dc.date2015-06-26T13:33:32Z
dc.date2015-11-26T15:32:45Z
dc.date.accessioned2018-03-28T22:41:12Z
dc.date.available2018-03-28T22:41:12Z
dc.identifier
dc.identifierFrontiers In Bioscience - Elite. , v. 1 E, n. 1, p. 189 - 199, 2009.
dc.identifier19450494
dc.identifier
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-77953623942&partnerID=40&md5=162f80e509956f465f99ea57c8b64c8e
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/91741
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/91741
dc.identifier2-s2.0-77953623942
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1262554
dc.descriptionMechanical stress is a major triggering stimulus for the installation of cardiac hypertrophy as well as for the structural and functional deterioration occurring in the hypertrophy decompensation. The sensing of mechanical forces and their conversion into biochemical signals depend on the integrity of subcellular structures such as the costameres and Z-disks. Signaling molecules concentrated into these structures are thought to be activated by the stress-induced deformation of structural proteins. Evidence also indicates that Ca2+ may be involved in mediating the mechanical forces conversion into biochemical signals and biological responses. Ca2+ channels, transporters and activated proteins are concentrated at the junctions between the T-tubules and the sarcoplasmic reticulum which are in close proximity to the costameres and Z-disks. This provides a structural basis for the influence of mechanical forces on Ca2+ transport and on the events related to signaling molecules clustered in the costameres and the Z-disks. Emerging data reviewed here are providing insight into how Ca2+ and mechanical mediated signaling are coordinated to modulate the functional and trophic responses of cardiac myocytes to mechanical stress.
dc.description1 E
dc.description1
dc.description189
dc.description199
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dc.languageen
dc.publisher
dc.relationFrontiers in Bioscience - Elite
dc.rightsfechado
dc.sourceScopus
dc.titleCalcium And The Mechanotransduction In Cardiac Myocytes
dc.typeArtículos de revistas


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