Standardizing Selection Criteria In Nasal Medication Studies [padronização Dos Critérios De Seleção Em Estudos Sobre Medicações Nasais]

dc.creatorBorin A.
dc.creatorAbib Jr. E.
dc.creatorAraujo C.I.
dc.creatorMartinez L.L.
dc.creatorRodrigues H.
dc.date2009
dc.date2015-06-26T13:33:15Z
dc.date2015-11-26T15:30:35Z
dc.date2015-06-26T13:33:15Z
dc.date2015-11-26T15:30:35Z
dc.date.accessioned2018-03-28T22:39:04Z
dc.date.available2018-03-28T22:39:04Z
dc.identifier
dc.identifierBrazilian Journal Of Otorhinolaryngology. , v. 75, n. 6, p. - , 2009.
dc.identifier18088694
dc.identifier
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-77649160754&partnerID=40&md5=e52e919462d87e9ff63f6fbf62ea6053
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/91681
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/91681
dc.identifier2-s2.0-77649160754
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1262028
dc.descriptionClinical studies on nasal topical medications require the standardization of "nasosinusal normality" in order to establish control groups through a specific evaluation of the upper airways. Aim: to standardize the evaluation of candidates for control groups in clinical studies on nasal topical medications. Material and Methods: healthy male volunteers of 18 to 50 years of age, asymptomatic from the nasosinusal standpoint were subjected to a sequential and excluding assessment made up of clinical evaluation, immediate hypersensitivity skin test, saccharin test, flexible nasofibroscopy and nasal cytology. Study design: Crosssectional contemporary cohort. Results: Of the 33 people originally enrolled, 14 (42.4%) were excluded for clinical reasons. Of the 19 remaining, 2 (10.5%) had atopy diagnosed in the skin test and were excluded. 17 were tested with saccharin and presented normal mucociliary clearance. Evaluation by nasal endoscopy showed abnormality in 2 cases (11.8%) and these were excluded. The remaining 15 were submitted to nasal cytology, which proved normal, representing 45.5% of those initially included. Conclusion: The proposed protocol for sequential and excluding evaluation was effective in defining candidates for the establishment of control groups in clinical studies on nasal topical medications. © Revista Brasileira de Otorrinolaringologia. All Rights reserved.
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dc.languagept
dc.languageen
dc.publisher
dc.relationBrazilian Journal of Otorhinolaryngology
dc.rightsaberto
dc.sourceScopus
dc.titleStandardizing Selection Criteria In Nasal Medication Studies [padronização Dos Critérios De Seleção Em Estudos Sobre Medicações Nasais]
dc.typeArtículos de revistas


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