Histopathologic Study On The Effects Of Tenoxicam With Bidistilled Water Or With 0.9% Sodium Chloride In Rabbits Venous Endothelium [estudo Histopatológico Do Efeito Do Tenoxicam Com água Bidestilada Ou Com Cloreto De Sódio A 0,9% No Endotélio Venoso De Coelhos]

dc.creatorSchnaider T.B.
dc.creatorDa Silva A.L.
dc.creatorBrasil Engelman M.D.F.
dc.creatorJuliano Y.
dc.creatorNovo N.F.
dc.creatorSchnaider G.S.
dc.creatorSchnaider C.S.
dc.date2002
dc.date2015-06-30T16:38:50Z
dc.date2015-11-26T15:30:32Z
dc.date2015-06-30T16:38:50Z
dc.date2015-11-26T15:30:32Z
dc.date.accessioned2018-03-28T22:39:00Z
dc.date.available2018-03-28T22:39:00Z
dc.identifier
dc.identifierRevista Brasileira De Anestesiologia. , v. 52, n. 2, p. 223 - 230, 2002.
dc.identifier347094
dc.identifier
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-0036130623&partnerID=40&md5=18828e3e903ef186907692ec2e32744b
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/101340
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/101340
dc.identifier2-s2.0-0036130623
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1262012
dc.descriptionBackground and Objectives - After exposure to indomethacin, human umbilical vein endothelial cells have shown increased procoagulant activity. Thrombosis in rabbit auricular veins has been observed after injection of tenoxicam with its diluent or of the diluent alone. Human studies evaluating venous endothelium after tenoxican injection were not found in the literature. This study aimed at evaluating whether tenoxicam with 0.9% sodium chloride changes the venous endothelium of rabbits as it is observed when associated to its diluent (bidistilled water). Methods - The study involved 90 rabbits (2000 and 3500 grams) divided in two groups: Control group, which received 0.9% NaCl; Experimental group, which received tenoxicam (20 mg) with bidistilled water or with 0.9% NaCl. A constant volume of 2 ml was administered to both groups. Anesthesia was induced with acepromazine maleate, ketamine hydrochloride and xylazine hydrochloride, and the puncture of right and left caudal auricular veins was performed with a 27G butterfly needle. Animals were confined for 6 hrs, 12 hrs, and 24 hrs, when they were once more anesthetized and sacrificed, with extraction of the auriculae at their base, followed by microscopic venous study. Results - Thrombosis was observed in 19.4% of the Experimental Group after the administration of tenoxicam with bidistilled water and in 22.2% after the administration of tenoxicam with 0.9% sodium chloride. In the Control group, which has only received 0.9% sodium chloride, no thrombosis was observed. Conclusions - It was possible to conclude that tenoxicam, either with bidistilled water or 0.9% sodium chloride, has induced thrombosis in the veins it was injected.
dc.description52
dc.description2
dc.description223
dc.description230
dc.descriptionNygard, G., Hudson, M., Mazure, G., Procoagulant and prothrombotic responses of human endothelium to indomethacin and endotoxin in vitro. Relevance to non-steroidal anti-inflammatory drug enteropathy (1995) Scand J Gastroenterol, 30, pp. 25-32
dc.descriptionSchnaider, T.B., Andrade, C.H.V., Juliano, Y., Estudo histopatológico do efeito do tenoxicam e do seu diluente no endotélio venoso, em coelhos (2000) Acta Cir Bras, 15, pp. 118-123
dc.descriptionCotran, R.S., Kumar, V., Robbins, S., (1996) Robbins Patologia Estrutural e Funcional, 5 a Ed., pp. 84-109. , Rio de Janeiro, Guanabara Koogan
dc.descriptionWhittle, B.J.R., Morishita, T., Ohya, Y., Microvascular actions of platelet-activating factor on rat gastric mucosa and submucosa (1986) Am J Physiol, 251, pp. G772-G778
dc.descriptionWallace, J.L., Keenan, C.M., Granger, D.N., Gastric ulceration induced by nonsteroidal anti-inflammatory drugs is a neutrophil-dependent process (1990) Am J Physiol, 259, pp. G462-G467
dc.descriptionWallace, J.L., Lipid mediators of inflammation in gastric ulcer (1990) Am J Physiol, 21, pp. G1-G11
dc.descriptionRang, H.P., Dale, M.M., Ritter, J.M., (2001) Farmacologia, 2 a Ed., pp. 255-269. , Rio de Janeiro, Guanabara Koogan
dc.languagept
dc.languageen
dc.publisher
dc.relationRevista Brasileira de Anestesiologia
dc.rightsfechado
dc.sourceScopus
dc.titleHistopathologic Study On The Effects Of Tenoxicam With Bidistilled Water Or With 0.9% Sodium Chloride In Rabbits Venous Endothelium [estudo Histopatológico Do Efeito Do Tenoxicam Com água Bidestilada Ou Com Cloreto De Sódio A 0,9% No Endotélio Venoso De Coelhos]
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución