The Influence Of Sevoflurane And Isoflurane On The Recovery From Cisatracurium-induced Neuromuscular Block [influência Do Sevoflurano E Do Isoflurano Na Recuperação Do Bloqueio Neuromuscular Produzido Pelo Cisatracúrio]

dc.creatorDe Assuncao Braga A.D.F.
dc.creatorDa Silva Braga F.S.
dc.creatorBraga Poterio G.M.
dc.creatorCremonesi E.
dc.creatorMauro G.
dc.date2002
dc.date2015-06-30T16:38:48Z
dc.date2015-11-26T15:30:31Z
dc.date2015-06-30T16:38:48Z
dc.date2015-11-26T15:30:31Z
dc.date.accessioned2018-03-28T22:38:59Z
dc.date.available2018-03-28T22:38:59Z
dc.identifier
dc.identifierRevista Brasileira De Anestesiologia. , v. 52, n. 5, p. 517 - 524, 2002.
dc.identifier347094
dc.identifier
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-0036739239&partnerID=40&md5=29c266dca902f2202807b224474dba15
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/101338
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/101338
dc.identifier2-s2.0-0036739239
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1262005
dc.descriptionBackground and Objectives - The effects of neuromuscular blockers on the neuromuscular junction are potentiated by volatile anesthetics. This study aimed at evaluating the influence of sevoflurane and isoflurane on the recovery of cisatracurium-induced neuromuscular block. Methods - Ninety ASA I and II patients undergoing elective surgeries under general anesthesia were included in this study. Patients were allocated in three groups: Group I (sevoflurane), Group II (isoflurane) and Group III (propofol). All patients were premedicated with intramuscular midazolam (0.1 mg.kg-1) 30 min before surgery. Anesthesia was induced with alfentanil (50 μg.kg-1), propofol (2.5 mg.kg-1) and cisatracurium (0.15 mg.kg-1). Patients were then ventilated under mask with 100% O2 until disappearance of all TOF responses when laryngoscopy and tracheal intubation were performed. Volatile agents for anesthetic maintenance were introduced immediately after tracheal intubation in 2% and 1% concentrations, respectively, for sevoflurane and isoflurane, as well as the propofol continuous infusion (7 to 10 mg.kg-1.h-1) for Group III. All patients received a 50% mixture of O2 and N2O. Neuromuscular function was monitored by adductor pollicis muscle acceleromyography with TOF stimulation at 15-second intervals. Clinical duration of neuromuscular block (T125%) and recovery index (RI=T125.75%) were evaluated. Results - Mean time and standard deviation for clinical duration (T125%) and recovery index (RI=T125.75%) were respectively: Group I (66.2 ± 13.42 min and 23.6 ± 5.02 min), Group II (54.4 ± 6.58 min and 14.9 ± 3.82 min) and Group III (47.2 ± 7.43 min and 16.2 ± 2.93 min). There were significant differences in clinical duration between Groups I and II, I and III and II and III. There was a significant difference in recovery index between Group I and the other groups. Conclusions - The recovery from cisatracurium-induced neuromuscular block was longer during anesthesia with volatile agents as compared to propofol. The most pronounced effect was observed with sevoflurane.
dc.description52
dc.description5
dc.description517
dc.description524
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dc.languagept
dc.languageen
dc.publisher
dc.relationRevista Brasileira de Anestesiologia
dc.rightsfechado
dc.sourceScopus
dc.titleThe Influence Of Sevoflurane And Isoflurane On The Recovery From Cisatracurium-induced Neuromuscular Block [influência Do Sevoflurano E Do Isoflurano Na Recuperação Do Bloqueio Neuromuscular Produzido Pelo Cisatracúrio]
dc.typeArtículos de revistas


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