Artículos de revistas
Clinicopathological Aspects And Their Relation To Prognosis In Adult-type Granulosa Cell Tumor Of The Ovary [aspectos Clinicopatológicos E Sua Relação Com O Prognóstico Em Tumor De Células Da Granulosa Do Tipo Adulto Do Ovário]
Registro en:
Jornal Brasileiro De Patologia E Medicina Laboratorial. , v. 45, n. 5, p. 395 - 400, 2009.
16762444
2-s2.0-75649102531
Autor
De Angelo Andrade M.
De Brito Pupo J.
Derchain S.
De Angelo Andrade L.A.L.
Institución
Resumen
Introduction and objective: The adult granulosa cell tumors (AGCT) correspond to less than 5% of ovarian neoplasias. They are considered low malignant potential tumors and may recur after many years. The differential diagnosis must be made with other primary or metastatic ovarian neoplasias. The aim was to analyze clinical and pathological aspects of AGCT and relate them to its evolution. Method: in a 10- year (1995-2004) review of the files from University of Campinas Clinical Hospital, Brazil, 20 AGCT cases were found. The clinical records and slides were reviewed and age, symptoms, macro and microscopic aspects, diagnostic staging and recurrence were considered. When there was intraoperative biopsy, its accuracy was evaluated. Results: Age ranged from 27 to 79 years (mean: 53) and the follow-up from 12 to 96 months (mean: 42). The main symptoms were post-menopause bleeding (45%), abdominal pain (35%) and palpable mass (25%). Most tumors were yellowish (60%) and the solid aspect (40%) was more common than the cystic or solid-cystic. The histological patterns were 40% solid, 15% macrofollicular and 45% combined forms. All of them with low mitotic index. Only three out of nine intraoperative frozen sections were accurately diagnosed. The clinical staging was 13 cases in Ia (65%), one case Ic and 6 IIIc. In three out of 14 hysterectomies there was simple endometrial hyperplasia with no atypia. Only the disease staging was significantly associated with recurrence (p < 0.0001). Conclusion: ACGT generally occurs after menopause and intraoperative biopsies are commonly inconclusive. Only advanced staging was related to the worst prognosis. 45 5 395 400 Auranen, A., Prognostic factors of ovarian granulosa cell tumor: A study of 35 patients and review of the literature (2007) Int J Gynecol Cancer, 17, pp. 1011-1018 Brooks, S.E., Zweizig, S.L., Wakeley, K., Ovarian cancer: A clinician's perspective (2006) Pathology Case Reviews, 11 (1), pp. 3-8 Fox, H., Agrawal, K., Langley, F.A., A clinicopathologic study of 92 cases of granulosa cell tumor of the ovary with special reference to the factors influencing prognosis (1975) Cancer, 35, pp. 231-241 Fujimoto, T., Histopathological prognostic factors of adult granulosa cell tumors of the ovary (2001) Acta Obstet Gynecol Scand, 80, pp. 1069-1074 Kim, Y.M., Adult granulosa cell tumor of the ovary: 35 cases in a single Korean Institute (2006) Acta Obstet Gynecol Scand, 85, pp. 112-115 Mccluggage, W.G., Immunohistochemical and functional biomarkers of value in female genital tract lesions (2006) Int J Gynecol Pathol, 25, pp. 101-120 Miller, K., Mccluggage, W.G., Prognostic factors in ovarian adult granulose cell tumor (2008) J Clin Pathol, 61 (8), pp. 881-884 Pinto, P.B.C., Andrade L, A.L.A., Derchain, S.F.M., Accuracy of intraoperative frozen section diagnosis of ovarian tumors (2001) Gynecol Oncology, 81, pp. 230-232 Roth, L.M., Recent advances in the pathology and classification of ovarian sex cord-stromal tumors (2006) Int J Gynecol Pathol, 25, pp. 199-215 Scully, R.E., Young, R.H., Clement, P.B., Tumors of the ovary, maldeveloped gonads, Fallopian tube and broad ligament (1998) Atlas of Tumor Pathology, , Fascicle 23, Washington, DC: AFIP Singh-ranger, G., Sharp, A., Crinnion, J.N., Recurrence of granulosa cell tumor after thirty years with small bowel obstruction (2004) Int Semin Surg Oncol, 1 (1), p. 4 Stuart, G.C.E., Dawson, L.M., Update on granulosa cell tumors of the ovary (2003) Curr Opinion Obstet Gynecol, 15, pp. 33-37 Tavassoli, F.A., Deville, P., Tumors of the breast and female genital organs (2003) World Health Organization Classification of Tumors, , TAVASSOLI, F. A. DEVILLE, P. (eds.). Lyon: IARC Press