Metabolic Profiling Of Human Blood Serum From Treated Patients With Bipolar Disorder Employing 1h Nmr Spectroscopy And Chemometrics

dc.creatorSussulini A.
dc.creatorPrando A.
dc.creatorMaretto D.A.
dc.creatorPoppi R.J.
dc.creatorTasic L.
dc.creatorBanzato C.E.M.
dc.creatorArruda M.A.Z.
dc.date2009
dc.date2015-06-26T13:32:19Z
dc.date2015-11-26T15:29:03Z
dc.date2015-06-26T13:32:19Z
dc.date2015-11-26T15:29:03Z
dc.date.accessioned2018-03-28T22:37:46Z
dc.date.available2018-03-28T22:37:46Z
dc.identifier
dc.identifierAnalytical Chemistry. , v. 81, n. 23, p. 9755 - 9763, 2009.
dc.identifier32700
dc.identifier10.1021/ac901502j
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-73249130205&partnerID=40&md5=3b1c212759916ef4a33ebeece086eb3d
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/91536
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/91536
dc.identifier2-s2.0-73249130205
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1261748
dc.descriptionMetabolic profiling employing hydrogen nuclear magnetic resonance ( 1H NMR) spectroscopy and chemometric analysis of human blood serum samples taken from the control group ( n = 25) and patients with bipolar disorder ( n = 25) was performed to identify molecular changes related to the disorder and to different drug treatments: lithium ( n = 15) versus other medications ( n = 10). This strategy showed significant potential for exploring pathophysiological and toxicological features involved in bipolar disorder. The investigated groups (control and patients with bipolar disorder under different treatments) could be distinguished according to their metabolic profiles, and the main differential metabolites found were lipids, lipid-metabolism-related molecules (acetate, choline, and myo-inositol), and some key amino acids (glutamate, glutamine). Our results suggest that some of the 24 identified metabolites may be linked to lithium- and other-medicationprovoked metabolic changes or may even be directly related to the disorder. Thus, these findings may contribute to paving the way for future studies aiming at identifying potential biomarkers for bipolar disorder. © 2009 American Chemical Society.
dc.description81
dc.description23
dc.description9755
dc.description9763
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dc.languageen
dc.publisher
dc.relationAnalytical Chemistry
dc.rightsfechado
dc.sourceScopus
dc.titleMetabolic Profiling Of Human Blood Serum From Treated Patients With Bipolar Disorder Employing 1h Nmr Spectroscopy And Chemometrics
dc.typeArtículos de revistas


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