dc.creator | Aloe F. | |
dc.creator | Alves R.C. | |
dc.creator | Araujo J.F. | |
dc.creator | Azevedo A. | |
dc.creator | Bacelar A. | |
dc.creator | Bezerra M. | |
dc.creator | Bittencourt L.R.A. | |
dc.creator | Bustamante G. | |
dc.creator | De Oliveira Cardoso T.A.M. | |
dc.creator | Eckeli A.L. | |
dc.creator | Fernandes R.M.F. | |
dc.creator | Goulart L. | |
dc.creator | Pradella-Hallinan M. | |
dc.creator | Hasan R. | |
dc.creator | Sander H.H. | |
dc.creator | Pinto Jr. L.R. | |
dc.creator | Lopes M.C. | |
dc.creator | Minhoto G.R. | |
dc.creator | Moraes W. | |
dc.creator | Moreira G.A. | |
dc.creator | Pachito D. | |
dc.creator | Pedrazolli M. | |
dc.creator | Poyares D. | |
dc.creator | Prado L. | |
dc.creator | Rizzo G. | |
dc.creator | Rodrigues R.N. | |
dc.creator | Roitman I. | |
dc.creator | Silva A.B. | |
dc.creator | Tavares S.M.A. | |
dc.date | 2010 | |
dc.date | 2015-06-26T12:37:44Z | |
dc.date | 2015-11-26T15:27:35Z | |
dc.date | 2015-06-26T12:37:44Z | |
dc.date | 2015-11-26T15:27:35Z | |
dc.date.accessioned | 2018-03-28T22:36:17Z | |
dc.date.available | 2018-03-28T22:36:17Z | |
dc.identifier | | |
dc.identifier | Revista Brasileira De Psiquiatria. , v. 32, n. 3, p. 305 - 314, 2010. | |
dc.identifier | 15164446 | |
dc.identifier | 10.1590/S1516-44462010000300016 | |
dc.identifier | http://www.scopus.com/inward/record.url?eid=2-s2.0-77958506725&partnerID=40&md5=6c6a85527763d5a1e7a92a9a1c726a43 | |
dc.identifier | http://www.repositorio.unicamp.br/handle/REPOSIP/91237 | |
dc.identifier | http://repositorio.unicamp.br/jspui/handle/REPOSIP/91237 | |
dc.identifier | 2-s2.0-77958506725 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1261389 | |
dc.description | This manuscript contains the conclusion of the consensus meeting of the Brazilian Sleep Association with Brazilian sleep specialists on the treatment of narcolepsy based on the review of medical literature from 1980 to 2010. The manuscript objectives were to reinforce the use of agents evaluated in randomized placebo-controlled trials and to issue consensus opinions on the use of other available medications as well as to inform about safety and adverse effects of these medications. Management of narcolepsy relies on several classes of drugs, namely, stimulants for excessive sleepiness, antidepressants for cataplexy and hypnotics for disturbed nocturnal sleep. Behavioral measures are likewise valuable and universally recommended. All therapeutic trials were analyzed according to their class of evidence. Recommendations concerning the treatment of each single symptom of narcolepsy as well as general recommendations were made. Modafinil is the first-line pharmacological treatment of excessive sleepiness. Second-line choices for the treatment of excessive sleepiness are slow-release metylphenidate followed by mazindol. The first-line treatments of cataplexy are the antidepressants, reboxetine, clomipramine, venlafaxine, desvenlafaxine or high doses of selective serotonin reuptake inibitors antidepressants. As for disturbed nocturnal sleep the best option is still hypnotics. Antidepressants and hypnotics are used to treat hypnagogic hallucinations and sleep paralysis. | |
dc.description | 32 | |
dc.description | 3 | |
dc.description | 305 | |
dc.description | 314 | |
dc.description | Morgenthaler, T.I., Kapur, V.K., Brown, T., Swick, T.J., Alessi, C., Aurora, R.N., Boehlecke, B., Zak, R., Practice parameters for the treatment of narcolepsy and other hypersomnias of central origin (2007) Sleep, 30 (12), pp. 1705-1711. , Standards of Practice Committee of the American Academy of Sleep Medicine | |
dc.description | Sackett, D.L., Rules of evidence and clinical recommendations for the management of patients (1993) Can J Cardiol, 9 (6), pp. 487-489 | |
dc.description | Eddy, D., (1992) A Manual for Assessing Health Practices and Designing Practice Policies: The Explicit Approach, , Philadelphia: American College of Physicians | |
dc.description | Levels of Evidence, , http://www.cebm.net/index.aspx0=1025, Web Site. [cited 2009 dez 16]. Available from | |
dc.description | Delbecq, A., Vande Ven, A., A group process model for prob lem identification and programme planning (1971) J Appl Behav Sci, 7, pp. 467-492 | |
dc.description | Britton, T., Hansen, A., Hicks, J., Howard, R., Meredith, A., (2002) Guidelines on the Diagnosis and Management of Narcolepsy in Adults and Children. Evidence-Based Guidelines for the UK with Graded Recommendations, , Ashtead, UK: Taylor Patten Communications Ltd | |
dc.description | Guilleminault, C., Fromherz, S., Narcolepsy: Diagnosis and management (2005) Principles and Practice of Sleep Medicine, , Kryger MH, Roth T, Dement WC, editors. 4th ed. Philadelphia: Saunders, Elsevier | |
dc.description | Billiard, M., Bassetti, C., Dauvilliers, Y., Dolenc-Groselj, L., Lammers, G.J., Mayer, G., Pollmacher, T., Sonka, K., EFNS guidelines on management of narcolepsy (2006) Eur J Neurol, 13 (10), pp. 1035-1048 | |
dc.description | Wise, M.S., Arand, D.L., Auger, R.R., Brooks, S.N., Watson, N.F., Treatment of narcolepsy and other hypersomnias of central origin (2007) Sleep, 30 (12), pp. 1712-1727 | |
dc.description | Roehrs, T., Zorick, F., Wittig, R., Paxton, C., Sicklesteel, J., Roth, T., Alerting effects of naps in patients with narcolepsy (1986) Sleep, 9, pp. 194-199 | |
dc.description | Mullington, J., Broughton, R., Scheduled naps in the management of daytime sleepiness in narcolepsy- Cataplexy (1993) Sleep, 16 (5), pp. 444-456 | |
dc.description | Rogers, A.E., Aldrich, M.S., Lin, X., A comparison of three different sleep schedules for reducing daytime sleepiness in narcolepsy (2001) Sleep, 24 (4), pp. 385-391 | |
dc.description | Chen, W., Mignot, E., Narcolepsy and hypersomnia of central origin: Diagnosis, differential pearls, and management (2007) Review of Sleep Medicine, pp. 75-94. , Barkoukis T, Avidan A, editors. 2nd ed. Philadelphia: Butterworth Heinman, Elsevier | |
dc.description | Zaharna, M., Dimitriu, A., Guilleminault, C., Expert opinion on pharmacotherapy of narcolepsy (2010) Expert Opin Pharmacother, , In press | |
dc.description | Zolkowska, D., Jain, R., Rothman, R.B., Partilla, J.S., Roth, B.L., Setola, V., Prisinzano, T.E., Baumann, M.H., Evidence for the involvement of dopamine transporters in behavioral stimulant effects of modafinil (2009) J Pharmacol Exp Ther, 329 (2), pp. 738-746 | |
dc.description | Boutrel, B., Koob, G.F., What keeps us awake: The neuropharmacology of stimulants and wakefulness-promoting medications (2004) Sleep, 27 (6), pp. 1181-1194 | |
dc.description | Volkow, N.D., Fowler, J.S., Logan, J., Alexoff, D., Zhu, W., Telang, F., Hooker, J.M., Apelskog-Torres, K., Effects of modafinil on dopamine and dopamine transporters in the male human brain (2009) JAMA, 301 (11), pp. 1148-1154 | |
dc.description | Qu, W.M., Huang, Z.L., Xu, X.H., Matsumoto, N., Urade, Y., Dopamin ergic D1 and D2 receptors are essential for the arousal effect of modafinil (2008) J Neurosci, 28 (34), pp. 8462-8469 | |
dc.description | Beierlein, M., Gibson, J.R., Connors, B.W., A network of electrically coupled interneurons drives synchronized inhibition in neocortex (2000) Nat Neurosci, 3 (9), pp. 904-910 | |
dc.description | Hestrin, S., Galarreta, M., Electrical synapses define networks of neocortical GABAergic neurons (2005) Trends in Neurosciences, 28 (6 SPEC. ISS), pp. 304-309. , DOI 10.1016/j.tins.2005.04.001, PII S0166223605000998 | |
dc.description | Garcia-Rill, E., Heister, D.S., Ye, M., Charlesworth, A., Hayar, A., Electrical coupling: Novel mechanism for sleep-wake control (2007) Sleep, 30 (11), pp. 1405-1414 | |
dc.description | Urbano, F.J., Leznik, E., Llinas, R.R., Modafinil enhances thalamocortical activity by increasing neuronal electrotonic coupling (2007) Proceedings of the National Academy of Sciences of the United States of America, 104 (30), pp. 12554-12559. , DOI 10.1073/pnas.0705087104 | |
dc.description | Beck, P., Odle, A., Wallace-Hunt, T., Skinner, R.D., Garcia-Rill, E., Modafinil increases arousal determined by P13 potential am plitude: An effect blocked by gap junction antagonists (2008) Sleep, 31 (12), pp. 1647-1654 | |
dc.description | Ferraro, L., Tanganelli, S., O'Connor, W.T., Antonelli, T., Rambert, F., Fuxe, K., The vigilance promoting drug modafinil decreases GABA release in the medial preoptic area and in the posterior hypothalamus of the awake rat: Possible involvement of the serotonergic 5-HT3 receptor (1996) Neuroscience Letters, 220 (1), pp. 5-8. , DOI 10.1016/S0304-3940(96)13212-2, PII S0304394096132122 | |
dc.description | Ferraro, L., Antonelli, T., O'Connor, W.T., Tanganelli, S., Rambert, F., Fuxe, K., The antinarcoleptic drug modafinil increases glutamate release in thalamic areas and hippocampus (1997) NeuroReport, 8 (13), pp. 2883-2887 | |
dc.description | De La Mora, M.P., Aguilar-Garcia, A., Ramon-Frias, T., Ramirez-Ramirez, R., Mendez-Franco, J., Rambert, F., Fuxe, K., Effects of the vigilance promoting drug modafinil on the synthesis of GABA and glutamate in slices of rat hypothalamus (1999) Neuroscience Letters, 259 (3), pp. 181-185. , DOI 10.1016/S0304-3940(98)00905-7, PII S0304394098009057 | |
dc.description | Willie, J.T., Renthal, W., Chemelli, R.M., Miller, M.S., Scammell, T.E., Yanagisawa, M., Sinton, C.M., Modafinil more effectively induces wakefulness in orexin-null mice than in wild-type littermates (2005) Neuroscience, 130 (4), pp. 983-995. , DOI 10.1016/j.neuroscience.2004.10.005, PII S0306452204009339 | |
dc.description | Scammell, T.E., Estabrooke, I.V., McCarthy, M.T., Chemelli, R.M., Yanagisawa, M., Miller, M.S., Saper, C.B., Hypothalamic arousal regions are activated during modafinil-induced wakefulness (2000) J Neurosci, 20 (22), pp. 8620-8628 | |
dc.description | Randomized trial of modafinil for the treatment of pathological somnolence in narcolepsy (1998) Ann Neurol, 43 (1), pp. 88-97. , US Modafinil in Narcolepsy Multicenter Study Group | |
dc.description | Randomized trial of modafinil as a treatment for the excessive daytime somnolence of narcolepsy (2000) Neurology, 54 (5), pp. 1166-1175. , US Modafinil in Narcolepsy Multicenter Study Group | |
dc.description | Broughton, R.J., Fleming, J.A.E., George, C.F.P., Hill, J.D., Kryger, M.H., Moldofsky, H., Montplaisir, J.Y., Murphy, W.F., Randomized, double-blind, placebo-controlled crossover trial of modafinil in the treatment of excessive daytime sleepiness in narcolepsy (1997) Neurology, 49 (2), pp. 444-451 | |
dc.description | Mitler, M.M., Hirsh, J., Hirshkowitz, M., Guilleminault, C., Long-term efficacy and safety of modafinil (PROVIGIL) for the treatment of excessive daytime sleepiness associated with narcolepsy (2000) Sleep Med, 1 (3), pp. 231-243. , for the US Modafinil in Narcolepsy Multicenter Study Group | |
dc.description | Moldofsky, H., Broughton, R.J., Hill, J.D., A randomized trial of the long-term, continued efficacy and safety of modafinil in narcolepsy (2000) Sleep Med, 1 (2), pp. 109-116 | |
dc.description | Schwartz, J., Feldman, N.T., Bogan, R.K., Dose response and dose regimen effects of modafinil in sustaining daytime wakefulness in narcoleptic patients with residual excessive sleepiness (2005) J Neuropsychiatry Clin Neurosci, 17 (3), pp. 405-412 | |
dc.description | Dauvilliers, Y., Neidhart, E., Billiard, M., Tafti, M., Sexual dimorphism of the catechol-O-methyltransferase gene in narcolepsy is associated with response to modafinil (2002) Pharmacogenomics Journal, 2 (1), pp. 65-68. , DOI 10.1038/sj.tpj.6500088 | |
dc.description | Robertson Jr., P., Hellriegel, E.T., Clinical pharmacokinetic profile of modafinil (2003) Clin Pharmacokinet, 42 (2), pp. 123-137 | |
dc.description | Wong, Y.N., Simcoe, D., Hartman, L.N., Laughton, W.B., King, S.P., McCormick, G.C., Grebow, P.E., A double-blind, placebo-controlled, ascending-dose evaluation of the pharmacokinetics and tolerability of modafinil tablets in healthy male volunteers (1999) Journal of Clinical Pharmacology, 39 (1), pp. 30-40. , DOI 10.1177/00912709922007534 | |
dc.description | Schawartz, J.R., Modafinil in the treatment of excessive sleepiness (2009) Drug des Devel Ther, 2, pp. 71-85 | |
dc.description | Kumar, R., Approved and investigational uses of modafinil: An evidence-based review (2008) Drugs, 68 (13), pp. 1803-1839 | |
dc.description | Walsleben, J.A., Ristanovic, R., Hirshkowitz, M., Provigil (modafinil) in the treatment of excessive daytime sleepiness in narcolepsy: Effect of previous treatment with stimulants on clinical response and safety (2000) Sleep, 23, pp. A303-4 | |
dc.description | Schwartz, J.R.L., Feldman, N.T., Fry, J.M., Harsh, J., Efficacy and safety of modafinil for improving daytime wakefulness in patients treated previously with psychostimulants (2003) Sleep Medicine, 4 (1), pp. 43-49. , DOI 10.1016/s1389-9457(02)00240-x | |
dc.description | Thorpy, M.J., Schwartz, J.R.L., Kovacevic-Ristanovic, R., Hayduk, R., Initiating treatment with modafinil for control of excessive daytime sleepiness in patients switching from methylphenidate: An open-label safety study assessing three strategies (2003) Psychopharmacology, 167 (4), pp. 380-385 | |
dc.description | Roth, T., Schwartz, J.R.L., Hirshkowitz, M., Erman, M.K., Dayno, J.M., Arora, S., Evaluation of the safety of modafinil for treatment of excessive sleepiness (2007) Journal of Clinical Sleep Medicine, 3 (6), pp. 595-602 | |
dc.description | Jasinski, D.R., Kovacevi-Ristanovi, R., Evaluation of the abuse liability of modafinil and other drugs for excessive daytime sleepiness associated with narcolepsy (2000) Clin Neuropharmacol, 23 (3), pp. 149-156 | |
dc.description | Myrick, H., Malcolm, R., Taylor, B., LaRowe, S., Modafinil: Preclinical, clinical, and post-marketing surveillance - A review of abuse liability issues (2004) Ann Clin Psychiatry, 16 (2), pp. 101-106 | |
dc.description | Jasisnki, D.R., An evaluation of the abuse potential of modafinil using methylphenidate as a reference (2000) J Psychopharmacol, 14 (1), pp. 53-60 | |
dc.description | Andersen, M.L., Kessler, E., Murnane, K.S., McClung, J.C., Tufik, S., Howell, L.L., Dopamine transporter-related effects of modafinil in rhesus monkeys (2010) Pshychopharmacology, 210 (3), pp. 439-448. , Berl | |
dc.description | Provigil Consumer Information, , www.fda.gov/cder/consumerinfo/druginfo/provigil, [cited 2009 mar 2]. Available from | |
dc.description | Bogan, R.K., Armodafinil in the treatment of excessive sleepiness (2010) Expert Opin Pharmacother, 11 (6), pp. 993-1002 | |
dc.description | Nishino, S., Okuro, M., Emerging treatments for narcolepsy and its related disorders (2010) Expert Opin Emerg Drugs, 15 (1), pp. 139-158 | |
dc.description | Auger, R.R., Goodman, S.H., Silber, M.H., Krahn, L.E., Pankratz, V.S., Slocumb, N.L., Risks of high-dose stimulants in the treatment of disorders of excessive somnolence: A case-control study (2005) Sleep, 28 (6), pp. 667-672 | |
dc.description | Dauvilliers, Y., Arnulf, I., Mignot, E., Narcolepsy with cataplexy (2007) Lancet, 369 (9560), pp. 499-511 | |
dc.description | Mitler, M.M., Hajdukovik, R., Relative efficacy of drugs used for the treatment of narcolepsy (1991) Sleep, 14 (3), pp. 218-220 | |
dc.description | Wallin, M.T., Mahowald, M.W., Blood pressure effects of long-term stimulant use in disorders of hypersomnolence (1998) J Sleep Res, 7 (3), pp. 209-215 | |
dc.description | Thorpy, M., Current concepts in the etiology, diagnosis and treatment of narcolepsy (2001) Sleep Med, 2 (1), pp. 5-17 | |
dc.description | Mitler, M.M., Aldrich, M.S., Koob, G.F., Zarcone, V.P., Narcolepsy and its treatment with stimulants. ASDA standards of practice (1994) Sleep, 17 (4), pp. 352-371 | |
dc.description | Shindler, J., Schachter, M., Brincat, S., Parkes, J.D., Amphetamine, mazindol, and fencamfamin in narcolepsy (1985) Br Med J (Clin Res Ed), 290 (6476), pp. 1167-1170 | |
dc.description | Lijima, S., Sugita, Y., Teshima, Y., Hishikawa, Y., Therapeutic effects of mazindol on narcolepsy (1986) Sleep, 9 (1 PART 2), pp. 265-268 | |
dc.description | Alvarez, B., Dahlitz, M., Grimshaw, J., Parkes, J.D., Mazindol in long-term treatment of narcolepsy (1991) Lancet, 337 (8752), pp. 1293-1294 | |
dc.description | Mayer, G., Meier-Ewert, K., Selegiline hydrochloride treatment in narcolepsy. A double-blind, placebo-controlled study (1995) Clin Neuropharmacol, 18 (4), pp. 306-319 | |
dc.description | Hublin, C., Partinen, M., Heinonen, E., Puuka, P., Salmi, T., Selegiline in the treatment of narcolepsy (1994) Neurology, 44 (11), pp. 2095-2101 | |
dc.description | Pratt, D.S., Dubois, R.S., Hepatotoxicity due to pemoline (Cylert): A report of two cases (1990) J Pediatr Gastroent Nutri, 10 (2), pp. 239-241 | |
dc.description | Nehra, A., Mullick, F., Ishak, K.G., Zimmerman, H.J., Pemoline-associated hepatic injury (1990) Gastroenterol, 99 (5), pp. 1517-1519 | |
dc.description | Beaumont, M., Batejat, D., Pierard, C., Coste, O., Doireau, P., Van Beers, P., Chauffard, F., Lagarde, D., Slow release caffeine and prolonged (64-h) continuous wakefulness: Effects on vigilance and cognitive performance (2001) Journal of Sleep Research, 10 (4), pp. 265-276. , DOI 10.1046/j.1365-2869.2001.00266.x | |
dc.description | Houghton, W.C., Scammell, T.E., Thorpy, M., Pharmacotherapy for cataplexy (2004) Sleep Med Rev, 8 (5), pp. 355-366 | |
dc.description | Vignatelli, L., D'Alessandro, R., Candelise, L., Antidepressant drugs for narcolepsy (2005) Cochrane Database Syst Rev, 20, p. 3. , CD0003724 | |
dc.description | Frey, J., Darbonne, C., Fluoxetine suppresses human cataplexy: A pilot study (1994) Neurology, 44 (4), pp. 707-709 | |
dc.description | Poceta, J.S., Hajdukovic, R., Mitler, M.M., Improvement in cataplexy with yohimbine and paroxetine: Case report (1994) Sleep Res, 23, p. 304 | |
dc.description | Thirumalai, S.S., Shubin, R.A., The use of citalopram in resistant cataplexy (2000) Sleep Med, 1 (4), pp. 313-316 | |
dc.description | Smith, M., Parkes, J.D., Dahlitz, M., Venlafaxine in the treatment of the narcoleptic syndrome (1996) J Sleep Res, 5, p. 217 | |
dc.description | Larrosa, O., De La Llave, Y., Bario, S., Granizo, J.J., Garcia-Bor Reguero, D., Stimulant and anticataplectic effects of reboxetine in patients with narcolepsy: A pilot study (2001) Sleep, 24 (3), pp. 282-285 | |
dc.description | Mayer, G., Meier-Ewert, K., Selegiline hydrochloride treatment in narcolepsy. A double-blind, placebo-controlled study (1995) Clin Neuropharmacol, 18 (4), pp. 306-319 | |
dc.description | A randomized, double-blind, placebo-controlled multicenter trial comparing the effects of three doses of orally administered sodium oxybate with placebo for the treatment of narcolepsy (2002) Sleep, 25 (1), pp. 42-49. , US XYREM Multicenter Study Group | |
dc.description | Further evidence support ing the use of sodium oxybate for the treatment of cataplexy: A double-blind, placebo-controlled study in 228 patients (2005) Sleep Med, 6 (5), pp. 415-421. , U.S. XYREM Multicenter Study Group | |
dc.description | A double-blind placebo controlled study demonstrates sodium oxybate is effective for the treatment of excessive daytime sleepiness in narcolepsy (2005) J Clin Sleep Med, 1 (4), pp. 391-397. , XYREM International Study Group | |
dc.description | Black, J., Houghton, W.C., Sodium oxybate improves excessive daytime sleepiness in narcolepsy (2006) Sleep, 29 (7), pp. 939-946 | |
dc.description | Lammers, G.J., Bassetti, C., Billiard, M., Black, J., Broughton, R., Dauvilliers, Y., Ferini Strambi, L., Thorpy, M., Sodium oxybate is an effective and safe treatment for narcolepsy (2010) Sleep Med, 11 (1), pp. 105-106 | |
dc.description | Grozinger, M., Hartter, S., Hiemke, C., Griese, E.-U., Roschke, J., Interaction of modafinil and clomipramine as comedication in a narcoleptic patient (1998) Clinical Neuropharmacology, 21 (2), pp. 127-129 | |
dc.description | Wu, D., Victoria Otton, S., Inaba, T., Kalow, W., Sellers, E.M., Interactions of amphetamine analogs with human liver CYP2D6 (1997) Biochemical Pharmacology, 53 (11), pp. 1605-1612. , DOI 10.1016/S0006-2952(97)00014-2, PII S0006295297000142 | |
dc.description | Thorpy, M.J., Snyder, M., Aloe, F.S., Ledereich, P.S., Starz, K.E., Short-term triazolam use improves nocturnal sleep of narcoleptics (1992) Sleep, 15 (3), pp. 212-216 | |
dc.description | Bonakis, A., Howard, R.S., Ebrahim, I.O., Merritt, S., Williams, A., REM sleep behaviour disorder (RBD) and its associations in young patients (2009) Sleep Med, 10 (6), pp. 641-645 | |
dc.description | Suzanne Hoover-Stevens, S., Ruzica Kovacevic-Ristanovic, R., Management of narcolepsy in pregnancy (2000) CIin Neuropharmacol, 23 (4), pp. 175-181 | |
dc.description | Rogers, A.E., Aldrich, M.S., Berrios, A.M., Rosenberg, R.S., Compliance with stimulant medications in patients with narcolepsy (1997) Sleep, 20 (1), pp. 28-33 | |
dc.language | pt | |
dc.language | en | |
dc.publisher | | |
dc.relation | Revista Brasileira de Psiquiatria | |
dc.rights | aberto | |
dc.source | Scopus | |
dc.title | Brazilian Guidelines For The Treatment Of Narcolepsy [diretrizes Brasileiras Para O Tratamento Da Narcolepsia] | |
dc.type | Artículos de revistas | |