Evaluation Of The Genotoxic And Antigenotoxic Effects After Acute And Subacute Treatments With Açai Pulp (euterpe Oleracea Mart.) On Mice Using The Erythrocytes Micronucleus Test And The Comet Assay

dc.creatorRibeiro J.C.
dc.creatorAntunes L.M.G.
dc.creatorAissa A.F.
dc.creatorDarin J.D.C.
dc.creatorDe Rosso V.V.
dc.creatorMercadante A.Z.
dc.creatorBianchi M.D.L.P.
dc.date2010
dc.date2015-06-26T12:37:06Z
dc.date2015-11-26T15:27:02Z
dc.date2015-06-26T12:37:06Z
dc.date2015-11-26T15:27:02Z
dc.date.accessioned2018-03-28T22:35:41Z
dc.date.available2018-03-28T22:35:41Z
dc.identifier
dc.identifierMutation Research - Genetic Toxicology And Environmental Mutagenesis. , v. 695, n. 1-2, p. 22 - 28, 2010.
dc.identifier13835718
dc.identifier10.1016/j.mrgentox.2009.10.009
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-77950350762&partnerID=40&md5=792e3cba3ba0901b5633fe8353427766
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/91144
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/91144
dc.identifier2-s2.0-77950350762
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1261247
dc.descriptionAçai, the fruit of a palm native to the Amazonian basin, is widely distributed in northern South America, where it has considerable economic importance. Whereas individual polyphenolics compounds in açai have been extensively evaluated, studies of the intact fruit and its biological properties are lacking. Therefore, the present study was undertaken to investigate the . in vivo genotoxicity of açai and its possible antigenotoxicity on doxorubicin (DXR)-induced DNA damage. The açai pulp doses selected were 3.33, 10.0 and 16.67. g/kg b.w. administered by gavage alone or prior to DXR (16. mg/kg b.w.) administered by intraperitoneal injection. Swiss albino mice were distributed in eight groups for acute treatment with açai pulp (24. h) and eight groups for subacute treatment (daily for 14 consecutive days) before euthanasia. The negative control groups were treated in a similar way. The results of chemical analysis suggested the presence of carotenoids, anthocyanins, phenolic, and flavonoids in açai pulp. The endpoints analyzed were micronucleus induction in bone marrow and peripheral blood cells polychromatic erythrocytes, and DNA damage in peripheral blood, liver and kidney cells assessed using the alkaline (pH >13) comet assay. There were no statistically significant differences (. p>. 0.05) between the negative control and the groups treated with the three doses of açai pulp alone in all endpoints analyzed, demonstrating the absence of genotoxic effects. The protective effects of açai pulp were observed in both acute and subacute treatments, when administered prior to DXR. In general, subacute treatment provided greater efficiency in protecting against DXR-induced DNA damage in liver and kidney cells. These protective effects can be explained as the result of the phytochemicals present in açai pulp. These results will be applied to the developmental of food with functional characteristics, as well as to explore the characteristics of açai as a health promoter. © 2009 Elsevier B.V..
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dc.languageen
dc.publisher
dc.relationMutation Research - Genetic Toxicology and Environmental Mutagenesis
dc.rightsfechado
dc.sourceScopus
dc.titleEvaluation Of The Genotoxic And Antigenotoxic Effects After Acute And Subacute Treatments With Açai Pulp (euterpe Oleracea Mart.) On Mice Using The Erythrocytes Micronucleus Test And The Comet Assay
dc.typeArtículos de revistas


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