Fetal Genotyping For Platelets Antigens: A Precise Tool For Alloimmune Thrombocytopenia: Case Report And Literature Review

dc.creatorNomura M.L.
dc.creatorCouto E.
dc.creatorMartinelli B.M.
dc.creatorBarjas-Castro M.L.
dc.creatorBarini R.
dc.creatorPassini Junior R.
dc.creatorCastro V.
dc.date2010
dc.date2015-06-26T12:36:39Z
dc.date2015-11-26T15:26:43Z
dc.date2015-06-26T12:36:39Z
dc.date2015-11-26T15:26:43Z
dc.date.accessioned2018-03-28T22:35:24Z
dc.date.available2018-03-28T22:35:24Z
dc.identifier
dc.identifierArchives Of Gynecology And Obstetrics. , v. 282, n. 5, p. 573 - 575, 2010.
dc.identifier9320067
dc.identifier10.1007/s00404-010-1415-3
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-78449271570&partnerID=40&md5=b53d1268559a618b6bf95a3fc81d8078
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/91103
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/91103
dc.identifier2-s2.0-78449271570
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1261173
dc.descriptionMaternal-fetal alloimmune thrombocytopenia complicates about 0.1% of all pregnancies and is associated with major fetal and neonatal morbidity and mortality, especially spontaneous central nervous system bleeding leading to death and neurological handicaps. Successful prevention and treatment depend on the identification of at-risk possible carriers of anti-platelet antibodies. Case report: We report a case of a mother with a previous child that developed neonatal hemorrhage; HPA-5b anti-platelet antibodies were detected post-natally. During the next pregnancy, fetal genotyping confirmed the presence of HPA-5b antigen; she was treated with weekly intravenous human immunoglobulin and oral prednisone. Pregnancy evolved without remarkable features and a full-term baby was delivered, with normal platelet counts. Conclusion: Fetal alloimmune thrombocytopenia is a potentially lethal condition, but early detection and prevention lead to successful outcome in most cases. © 2010 Springer-Verlag.
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dc.description573
dc.description575
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dc.languageen
dc.publisher
dc.relationArchives of Gynecology and Obstetrics
dc.rightsfechado
dc.sourceScopus
dc.titleFetal Genotyping For Platelets Antigens: A Precise Tool For Alloimmune Thrombocytopenia: Case Report And Literature Review
dc.typeArtículos de revistas


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