Artículos de revistas
Expression Of Prox-1 In Oral Kaposi's Sarcoma Spindle Cells
Registro en:
Journal Of Oral Pathology And Medicine. , v. 43, n. 2, p. 132 - 136, 2014.
9042512
10.1111/jop.12097
2-s2.0-84892873772
Autor
Benevenuto de Andrade B.A.
Ramirez-Amador V.
Anaya-Saavedra G.
Martinez-Mata G.
Fonseca F.P.
Graner E.
Paes de Almeida O.
Institución
Resumen
Background: The histogenesis of neoplastic spindle cells of Kaposi's sarcoma is still uncertain, but some studies consider it a lymphatic vessel differentiation. Prox-1 is a nuclear transcription factor that plays a major role during embryonic lymphangiogenesis, and it has been considered a specific and sensitive lymphatic endothelial cell marker. The aim of this study was to determine the expression of Prox-1 in oral Kaposi's sarcoma comparing the results with oral benign vascular tumors including capillary hemangiomas and pyogenic granulomas. Methods: Expression of Prox-1 and HHV-8 was evaluated by immunohistochemistry in 30 oral Kaposi's sarcoma, 5 oral capillary hemangiomas, and 10 oral pyogenic granulomas. The labeling index was expressed as the percentage of positive cells for each case studied. Statistical comparison was performed using the Wilcoxon-Mann-Whitney rank sum test. Results: Twenty-eight (93.3%) and 30 oral Kaposi's sarcoma cases were positive for Prox-1 and HHV-8, respectively, while all oral benign vascular tumors were negative for these markers. The number of Prox-1 and HHV-8 oral Kaposi's sarcoma-positive cells increased significantly from patch/plaque to nodular histological stages. Conclusion: The expression of Prox-1 in the neoplastic spindle cells supports the view of a lymphatic differentiation in oral Kaposi's sarcoma. Prox-1 may also be involved in the pathogenesis of oral Kaposi's sarcoma as the number of positive spindle cells increased progressively from patch to nodular stages and could be eventually useful as an additional diagnostic tool for differential diagnosis between oral Kaposi's sarcoma and benign oral vascular lesions. © 2013 John Wiley & Sons A/S. 43 2 132 136 Feller, L., Wood, N.H., Lemmer, J., HIV-associated Kaposi sarcoma: pathogenic mechanisms (2007) Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 104, pp. 521-529 Ramírez-Amador, V., Martínez-Mata, G., González-Ramírez, I., Anaya-Saavedra, G., de Almeida, O.P., Clinical, histological and immunohistochemical findings in oral Kaposi's sarcoma in a series of Mexican AIDS patients. Comparative study (2009) J Oral Pathol Med, 38, pp. 328-333 Beckstead, J.H., Wood, G.S., Fletcher, V., Evidence for the origin of Kaposi's sarcoma from lymphatic endothelium (1985) Am J Pathol, 119, pp. 294-300 Hong, Y.K., Foreman, K., Shin, J.W., Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma-associated herpesvirus (2004) Nat Genet, 36, pp. 683-685 Wang, H.W., Trotter, M.W., Lagos, D., Kaposi sarcoma herpesvirus-induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma (2004) Nat Genet, 36, pp. 687-693 Pyakurel, P., Pak, F., Mwakigonja, A.R., Kaaya, E., Heiden, T., Biberfeld, P., Lymphatic and vascular origin of Kaposi's sarcoma spindle cells during tumor development (2006) Int J Cancer, 119, pp. 1262-1267 Folpe, A.L., Veikkola, T., Valtola, R., Weiss, S.W., Vascular endothelial growth factor receptor-3 (VEGFR-3): a marker of vascular tumors with presumed lymphatic differentiation, including Kaposi's sarcoma, kaposiform and Dabska-type hemangioendotheliomas, and a subset of angiosarcomas (2000) Mod Pathol, 13, pp. 180-185 Carroll, P.A., Brazeau, E., Lagunoff, M., Kaposi's sarcoma-associated herpesvirus infection of blood endothelial cells induces lymphatic differentiation (2004) Virology, 328, pp. 7-18 Rodriguez-Niedenführ, M., Papoutsi, M., Christ, B., Prox1 is a marker of ectodermal placodes, endodermal compartments, lymphatic endothelium and lymphangioblasts (2001) Anat Embryol (Berl), 204, pp. 399-406 Lavado, A., Oliver, G., Prox1 expression patterns in the developing and adult murine brain (2007) Dev Dyn, 236, pp. 518-524 Wigle, J.T., Oliver, G., Prox1 function is required for the development of the murine lymphatic system (1999) Cell, 98, pp. 769-778 Wigle, J.T., Harvey, N., Detmar, M., An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype (2002) EMBO J, 21, pp. 1505-1513 Lamovec, J., Knuutila, S., Kaposi sarcoma (2002) World Health Organization Classification of tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone, pp. 170-172. , Fletcher CDM, Unni KK, Mertens F, eds. Lyon: IARC Press Reis, R.M., Reis-Filho, J.S., Longatto Filho, A., Tomarev, S., Silva, P., Lopes, J.M., Differential Prox-1 and CD 31 expression in mucousae, cutaneous and soft tissue vascular lesions and tumors (2005) Pathol Res Pract, 201, pp. 771-776 Dadras, S.S., Skrzypek, A., Nguyen, L., Prox-1 promotes invasion of kaposiform hemangioendotheliomas (2008) J Invest Dermatol, 128, pp. 2798-2806 Kahn, H.J., Bailey, D., Marks, A., Monoclonal antibody D2-40, a new marker of lymphatic endothelium, reacts with Kaposi's sarcoma and a subset of angiosarcomas (2002) Mod Pathol, 15, pp. 434-440 Le Huu, A.R., Jokinen, C.H., Rubin, B.P., Expression of prox1, lymphatic endothelial nuclear transcription factor, in Kaposiform hemangioendothelioma and tufted angioma (2010) Am J Surg Pathol, 34, pp. 1563-1573