Modulation Of Hypothalamic Ptp1b In The Tnf-α-induced Insulin And Leptin Resistance

dc.creatorPicardi P.K.
dc.creatorCaricilli A.M.
dc.creatorAbreu L.L.F.D.
dc.creatorCarvalheira J.B.C.
dc.creatorVelloso L.A.
dc.creatorSaad M.J.A.
dc.date2010
dc.date2015-06-26T12:35:47Z
dc.date2015-11-26T15:25:52Z
dc.date2015-06-26T12:35:47Z
dc.date2015-11-26T15:25:52Z
dc.date.accessioned2018-03-28T22:34:38Z
dc.date.available2018-03-28T22:34:38Z
dc.identifier
dc.identifierFebs Letters. , v. 584, n. 14, p. 3179 - 3184, 2010.
dc.identifier145793
dc.identifier10.1016/j.febslet.2010.05.064
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-77954175048&partnerID=40&md5=2989a3470d4622052558085a8ff2feb9
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/90999
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/90999
dc.identifier2-s2.0-77954175048
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1261000
dc.descriptionWe have associated functional and molecular studies of insulin and leptin to investigate the effect of TNF-α on central insulin and leptin signaling in rats pre-treated with PTP1B-ASO. The icv infusion of TNF-α-induced an increase in PTP1B protein expression and activity, and attenuated insulin and leptin sensitivity and signaling in the hypothalamus. However, TNF-α was able to completely blunt the leptin and insulin effect in rats treated with PTP1B-ASO, suggesting that TNF-α does not require PTP1B to fully attenuate the leptin and insulin effects. In addition, our data also show that other mechanisms of insulin and leptin resistance are activated in the hypothalamus by TNF-α. © 2010 Federation of European Biochemical Societies.
dc.description584
dc.description14
dc.description3179
dc.description3184
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dc.languageen
dc.publisher
dc.relationFEBS Letters
dc.rightsfechado
dc.sourceScopus
dc.titleModulation Of Hypothalamic Ptp1b In The Tnf-α-induced Insulin And Leptin Resistance
dc.typeArtículos de revistas


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