Hypoxia, Hypoxia-inducible Factor-1α And Vascular Endothelial Growth Factor In A Murine Model Of Schistosoma Mansoni Infection

dc.creatorAraujo A.P.
dc.creatorFrezza T.F.
dc.creatorAllegretti S.M.
dc.creatorGiorgio S.
dc.date2010
dc.date2015-06-26T12:35:44Z
dc.date2015-11-26T15:25:48Z
dc.date2015-06-26T12:35:44Z
dc.date2015-11-26T15:25:48Z
dc.date.accessioned2018-03-28T22:34:34Z
dc.date.available2018-03-28T22:34:34Z
dc.identifier
dc.identifierExperimental And Molecular Pathology. , v. 89, n. 3, p. 327 - 333, 2010.
dc.identifier144800
dc.identifier10.1016/j.yexmp.2010.09.003
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-78249235607&partnerID=40&md5=76ad6055c5e7ee11e9a5537df0e9d600
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/90988
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/90988
dc.identifier2-s2.0-78249235607
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1260986
dc.descriptionSchistosomiasis mansoni is a chronic parasitic disease where much of the symptomatology is attributed to granuloma formation, an immunopathological reaction against Schistosoma eggs. To more clearly understand the immunopathology of schistosomiasis, the tissue microenvironment generated by S. mansoni infected mice was investigated. Using the hypoxia marker pimonidazole, we provide immunohistochemical evidence that hypoxia occurred in inflammatory cells infiltrated around the eggs and cells surrounding granulomas in the liver, intestine, spleen and lungs of infected mice. Hypoxia-inducible factor-1α (HIF-1α) was mainly expressed in inflammatory cells surrounding the eggs and in hepatocytes surrounding cellular and fibrocellular granulomas in infected mouse liver. HIF-1α expression was also verified in granulomas in the other tissues tested (intestine, spleen and lungs). Vascular endothelial growth factor (VEGF) expression was observed in the extracellular space surrounding inflammatory cells in liver granuloma. The VEGF expression pattern verified in infected mouse liver was very similar to that observed in the other tissues tested. A strong positive correlation occurred between pimonidazole binding and HIF-1α and VEGF expression in the tissues tested, except for lung. This work is the first evidence that infection by a helminth parasite, S. mansoni, produces a hypoxic tissue microenvironment and induces HIF-1α and VEGF expression. © 2010 Elsevier Inc.
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dc.languageen
dc.publisher
dc.relationExperimental and Molecular Pathology
dc.rightsfechado
dc.sourceScopus
dc.titleHypoxia, Hypoxia-inducible Factor-1α And Vascular Endothelial Growth Factor In A Murine Model Of Schistosoma Mansoni Infection
dc.typeArtículos de revistas


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