dc.creator | Araujo A.P. | |
dc.creator | Frezza T.F. | |
dc.creator | Allegretti S.M. | |
dc.creator | Giorgio S. | |
dc.date | 2010 | |
dc.date | 2015-06-26T12:35:44Z | |
dc.date | 2015-11-26T15:25:48Z | |
dc.date | 2015-06-26T12:35:44Z | |
dc.date | 2015-11-26T15:25:48Z | |
dc.date.accessioned | 2018-03-28T22:34:34Z | |
dc.date.available | 2018-03-28T22:34:34Z | |
dc.identifier | | |
dc.identifier | Experimental And Molecular Pathology. , v. 89, n. 3, p. 327 - 333, 2010. | |
dc.identifier | 144800 | |
dc.identifier | 10.1016/j.yexmp.2010.09.003 | |
dc.identifier | http://www.scopus.com/inward/record.url?eid=2-s2.0-78249235607&partnerID=40&md5=76ad6055c5e7ee11e9a5537df0e9d600 | |
dc.identifier | http://www.repositorio.unicamp.br/handle/REPOSIP/90988 | |
dc.identifier | http://repositorio.unicamp.br/jspui/handle/REPOSIP/90988 | |
dc.identifier | 2-s2.0-78249235607 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1260986 | |
dc.description | Schistosomiasis mansoni is a chronic parasitic disease where much of the symptomatology is attributed to granuloma formation, an immunopathological reaction against Schistosoma eggs. To more clearly understand the immunopathology of schistosomiasis, the tissue microenvironment generated by S. mansoni infected mice was investigated. Using the hypoxia marker pimonidazole, we provide immunohistochemical evidence that hypoxia occurred in inflammatory cells infiltrated around the eggs and cells surrounding granulomas in the liver, intestine, spleen and lungs of infected mice. Hypoxia-inducible factor-1α (HIF-1α) was mainly expressed in inflammatory cells surrounding the eggs and in hepatocytes surrounding cellular and fibrocellular granulomas in infected mouse liver. HIF-1α expression was also verified in granulomas in the other tissues tested (intestine, spleen and lungs). Vascular endothelial growth factor (VEGF) expression was observed in the extracellular space surrounding inflammatory cells in liver granuloma. The VEGF expression pattern verified in infected mouse liver was very similar to that observed in the other tissues tested. A strong positive correlation occurred between pimonidazole binding and HIF-1α and VEGF expression in the tissues tested, except for lung. This work is the first evidence that infection by a helminth parasite, S. mansoni, produces a hypoxic tissue microenvironment and induces HIF-1α and VEGF expression. © 2010 Elsevier Inc. | |
dc.description | 89 | |
dc.description | 3 | |
dc.description | 327 | |
dc.description | 333 | |
dc.description | Albina, J.E., Mastrofrancesco, B., Vessella, J.A., Louis, C.A., Henry, W.L., Reichner, J.S., HIF-1 expression in healing wounds: HIF-1alpha induction in primary inflammatory cells by TNF-alpha (2001) Am. J. Physiol. Cell Physiol., 281, pp. C1971-C1977 | |
dc.description | Andrade, Z.A., Cheever, A.W., Alterations of the intrahepatic vasculature in hepatosplenic Schistosomiasis mansoni (1971) Am. J. Trop. Med. Hyg., 20, pp. 425-432 | |
dc.description | Arrais-Silva, W.W., Paffaro, V.A., Yamada, A.T., Giorgio, S., Expression of hypoxia-inducible factor-1α in the cutaneous lesions of BALB/c mice infected with Leishmania amazonensis (2005) Exp. Mol. Pathol., 78, pp. 49-54 | |
dc.description | Baptista, A.P., Andrade, A.A., Angiogenesis and schistosomal granuloma formation (2005) Mem. Inst. Oswaldo Cruz, 100, pp. 183-185 | |
dc.description | Bassnett, S., McNulty, R., The effect of elevated intraocular oxygen on organelle degradation in the embryonic chicken lens (2003) J. Exp. Biol., 206, pp. 4353-4361 | |
dc.description | Blouin, C.C., Page, E.L., Soucy, G.M., Richard, D.E., Hypoxic gene activation by lipopolysaccharide in macrophages: implication of hypoxia-inducible factor 1alpha (2004) Blood, 103, pp. 1124-1130 | |
dc.description | Botusan, I.R., Sunkari, V.G., Savu, O., Catrina, A.I., Grünler, J., Lindberg, S., Pereira, T., Catrina, S.B., Stabilization of HIF-1alpha is critical to improve wound healing in diabetic mice (2008) Proc. Natl Acad. Sci., 105, pp. 19426-19431 | |
dc.description | Burke, M.L., Jones, M.K., Gobert, G.N., Li, Y.S., Ellis, M.K., McManus, D.P., Immunopathogenesis of human schistosomiasis (2009) Parasite Immunol., 31, pp. 163-176 | |
dc.description | Carmeliet, P., Angiogenesis in life, disease and medicine (2005) Nature, 438, pp. 932-936 | |
dc.description | Catrina, S.B., Okamoto, K., Pereira, T., Brismar, K., Poellinger, L., Hyperglycemia regulates hypoxia-inducible factor-1alpha protein stability and function (2004) Diabetes, 53, pp. 3226-3232 | |
dc.description | Cheever, A.W., Lenzi, J.A., Lenzi, H.L., Andrade, Z.A., Experimental models of Schistosoma mansoni infection (2002) Mem. Inst. Oswaldo Cruz, 97, pp. 917-940 | |
dc.description | Couto, J.L.A., Vieira, R., Barbosa, J.M., Machado, S.S., Ferreira, H.S., Alterações da função hepática de camundongos desnutridos e infectados pelo Schistosoma mansoni (2008) Rev. Soc. Bras. Med. Trop., 41, pp. 390-393 | |
dc.description | Degrossoli, A., Bosetto, M.C., Lima, C.B.C., Giorgio, S., Expression of hypoxia-inducible factor 1α in mononuclear phagocytes infected with Leishmania amazonensis (2007) Immunol. Lett., 114, pp. 119-125 | |
dc.description | Edungbola, L.C., Shciller, L.E., Histopathology of hepatic and pulmonary granulomata experimentally induced with eggs of Schistosoma mansoni (1979) J. Parasitol., 65, pp. 253-261 | |
dc.description | Feldman, G.M., Dannenberg, A.M., Seed, J.L., Physiologic oxygen tensions limit oxidant-mediated killing of schistosome eggs by inflammatory cells and isolated granulomas (1990) J. Leukoc. Biol., 47, pp. 344-354 | |
dc.description | Freedman, D.O., Ottesen, E.A., Eggs of Schistosoma mansoni stimulate endothelial cell proliferation in vitro (1988) J. Infect. Dis., 158, pp. 556-562 | |
dc.description | Gobert, G.M., Chai, M., McManus, D.P., Biology of the schistosome lung-stage schistosomulum (2007) Parasitology, 134, pp. 453-460 | |
dc.description | Haeberle, H.A., Durrstein, C., Rosenberger, P., Hosakote, Y.M., Kuhlicke, J., Kempf, V.A., Garofalo, R.P., Eltzschig, H.K., Oxygen-independent stabilization of hypoxia inducible factor (HIF)-1 during RSV infection (2008) PLoS ONE, 3, pp. e3352 | |
dc.description | Höckel, M., Vaupel, P., Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects (2001) J. Natl Cancer Inst., 93, pp. 266-276 | |
dc.description | Janssen, H.L., Haustermans, K.M., Sprong, D., Blommestijn, G., Hofland, I., Hoebers, F.J., Blijweert, E., Begg, C., HIF-1A, pimonidazole, and iododeoxyuridine to estimate hypoxia and perfusion in human head-and-neck tumors (2002) Int. J. Radiat. Oncol. Biol. Phys., 54, pp. 1537-1549 | |
dc.description | Jiang, B.H., Semenza, G.L., Bauer, C., Marti, H.H., Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O 2 tension (1996) Am. J. Physiol., 271, pp. C1172-C1180 | |
dc.description | Kanse, S.M., Liang, O., Schubert, U., Haas, H., Preissner, K.T., Doenhoff, M.J., Dennis, R.D., Characterization and partial purification of Schistosoma mansoni egg-derived pro-angiogenic factor (2005) Mol. Biochem. Parasitol., 144, pp. 76-85 | |
dc.description | Kempf, V.A.J., Lebiedziejewski, M., Alitalo, K., Wälzlein, J., Ehehalt, U., Fiebig, J., Huber, S., Autenrieth, I.B., Activation of hypoxia-inducible factor-1 in bacillary angiomatosis. Evidence for a role of hypoxia-inducible factor-1 in bacterial infections (2005) Circulation, 111, pp. 1054-1062 | |
dc.description | Kietzmann, T., Görlach, A., Reactive oxygen species in the control of hypoxia-inducible-factor-mediated gene expression (2005) Semin. Cell Dev. Biol., 16, pp. 474-486 | |
dc.description | Klinkenberg, L.G., Sutherland, L.A., Bishai, W.R., Karakousis, P.C., Metronidazol lacks activity against Mycobacterium tuberculosis in an In Vivo hypoxic granuloma model of latency (2008) J. Infect. Dis., 198, pp. 275-283 | |
dc.description | Lenzi, H.L., Romanha, W.S., Santos, R.M., Rosas, A., Mota, E.M., Manso, P.P., Caputo, L.F., Pelajo-Machado, M., Four whole-istic aspects of schistosome granuloma biology: fractal arrangement, internal regulation, autopoietic component and closure (2006) Mem. Inst. Oswaldo Cruz, 101, pp. 219-231 | |
dc.description | Loeffler, D.A., Lundy, S.K., Singh, K.P., Gerard, H.C., Hudson, A.P., Boros, D.L., Soluble egg antigens from Schistosoma mansoni induce angiogenesis-related processes by up-regulating vascular endothelial growth factor in human endothelial cells (2002) J. Infect. Dis., 185, pp. 1650-1656 | |
dc.description | Lopes, I.C., Santos, V.C.R., Souza, V.L.R.B., Rodrigues, I.R.C., Histopathological study of Schistosoma mansoni infection in the murine model using the PC (Pará) and LILA (Maranhão) strains (2006) Mem. Inst. Oswaldo Cruz, 10, pp. 273-277 | |
dc.description | Nizet, V., Johnson, R.S., Interdependence of hypoxic and innate immune responses (2009) Nat. Rev. Immunol., 9, pp. 609-617 | |
dc.description | Pagé, E.L., Chan, D.A., Giaccia, A.J., Levine, M., Richard, D.E., Hypoxia-inducible factor-1alpha stabilization in nonhypoxic conditions: role of oxidation and intracellular ascorbate depletion (2008) Mol. Biol. Cell, 19, pp. 86-94 | |
dc.description | Park, J.E., Keller, G.A., Ferreira, N., The vascular endothelial growth factor (VEGF) isoforms: differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF (1993) Mol. Biol. Cell, 4, pp. 1317-1326 | |
dc.description | Pearce, E.J., MacDonald, A.S., The immunobiology of schistosomiasis (2002) Nat. Rev. Immunol., 2, pp. 499-511 | |
dc.description | Pugh, C.W., Ratcliffe, P.J., Regulation of angiogenesis by hypoxia: role of the HIF system (2003) Nat. Med., 9, pp. 677-684 | |
dc.description | Raleigh, J.A., Chou, S.C., Arteel, G.E., Horsman, M.R., Comparisons among pimonidazole binding, oxygen electrode measurements, and radiation response in C3H mouse tumors (1999) Radiat. Res., 151, pp. 580-589 | |
dc.description | Ramos, M.A., Kuzuya, M., Esaki, T., Miura, S., Satake, S., Asai, T., Kanda, S., Iguchi, A., Induction of macrophage VEGF in response to oxidized LDL and VEGF accumulation in human atherosclerotic lesions (1998) Arterioscler. Thromb. Vasc. Biol., 18, pp. 1188-1196 | |
dc.description | Rasey, J.S., Hofstrand, P.D., Chin, L.K., Tewson, T.J., Characterization of [18F]fluoroetanidazole, a new radiopharmaceutical for detecting tumor hypoxia (1999) J. Nucl. Med., 40, pp. 1072-1079 | |
dc.description | Semenza, G.L., Agani, F., Feldser, D., Iyer, N., Kotch, L., Laughner, E., Yu, A., Hypoxia, HIF-1, and the pathophysiology of common human disease (2000) Adv. Exp. Med. Biol., 475, pp. 123-130 | |
dc.description | Shi, S.R., Key, M.E., Kalra, K.L., Antigen retrieval in formalin-fixed, paraffin-embedded tissues: an enhancement method for immunohistochemical staining based on microwave oven heating of tissue sections (1991) J. Histochem. Cytochem., 39, pp. 741-748 | |
dc.description | Sobhanifar, S., Aquino-Parsons, C., Stanbridge, E.J., Olive, P., Reduced expression of hypoxia-inducible factor-1alpha in perinecrotic regions of solid tumors (2005) Cancer Res., 65, pp. 7259-7266 | |
dc.description | Spear, W., Chan, D., Coppens, I., Johnson, R.S., Giaccia, A., Blader, I.J., The host cell transcription factor hypoxia-inducible factor 1 is required for Toxoplasma gondii growth and survival at physiological oxygen levels (2006) Cell. Microbiol., 8, pp. 339-352 | |
dc.description | Stadecker, M.J., The development of granulomas in schistosomiasis: genetic backgrounds, regulatory pathways, and specific egg antigen responses that influence the magnitude of disease (1999) Microbes Infect., 1, pp. 505-510 | |
dc.description | Stavitsky, A.B., Regulation of granulomatous inflammation in experimental models of schistosomiasis (2004) Infect. Immun., 72, pp. 1-12 | |
dc.description | Uchida, T., Rossignol, F., Matthay, M.A., Mounier, R., Couette, S., Clottes, E., Clerici, C., Prolonged hypoxia differentially regulates hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression in lung epithelial cells: implication of natural antisense HIF-1alpha (2004) J. Biol. Chem., 279, pp. 14871-14878 | |
dc.description | Vaupel, P., Harrison, L., Tumor hypoxia: causative factors, compensatory mechanisms, and cellular response (2004) Oncologist, 9, pp. 4-9 | |
dc.description | Via, L.E., Lin, P.L., Ray, S.M., Carrillo, J., Allen, S.S., Eum, S.I., Taylor, K., Barry, C.E., Tuberculous granulomas are hypoxic in guinea pigs, rabbits, and nonhuman primates (2008) Infect. Immun., 76, pp. 2333-2340 | |
dc.description | von Lichtenberg, F., Sher, A., McIntyre, S., A lung model of schistosome immunity in mice (1977) Am. J. Pathol., 87, pp. 105-123 | |
dc.description | Vordermark, D., Kraft, P., Katzer, A., Bölling, T., Willner, J., Flentje, M., Glucose requirement for hypoxic accumulation of hypoxia-inducible factor-1alpha (HIF-1alpha) (2005) Cancer Lett., 30, pp. 122-133 | |
dc.description | Wilson, M.S., Mentink-Kane, M.M., Pesce, J.T., Ramalingam, T.R., Thompson, R., Wynn, T.A., Immunopathology of schistosomiasis (2007) Immunol. Cell Biol., 85, pp. 148-154 | |
dc.description | Yoshioka, L., Zanotti-Magalhães, E.M., Magalhães, L.A., Linares, A.X., Schistosoma ansoni: a study of pathogenesis of Santa Rosa strain (Campinas, SP, Brasil) in mice (2002) Rev. Soc. Bras. Med. Trop., 35, pp. 203-207 | |
dc.description | Zinkernagel, A.S., Johnson, R.S., Nizet, V., Hypoxia inducible factor (HIF) function in innate immunity and infection (2007) J. Mol. Med., 85, pp. 1339-1346 | |
dc.language | en | |
dc.publisher | | |
dc.relation | Experimental and Molecular Pathology | |
dc.rights | fechado | |
dc.source | Scopus | |
dc.title | Hypoxia, Hypoxia-inducible Factor-1α And Vascular Endothelial Growth Factor In A Murine Model Of Schistosoma Mansoni Infection | |
dc.type | Artículos de revistas | |