Antibody Responses In Mice After Immunization With Inactivated Bovine Respiratory Syncytial Virus Using Different Adjuvants [respostas De Anticorpos Em Camundongos Após Imunização Com Vírus Respiratório Sincicial Bovino Inativado Utilizando Diferentes Adjuvantes]

dc.creatorSpilki F.R.
dc.creatorde Almeida R.S.
dc.creatorArns C.W.
dc.date2010
dc.date2015-06-26T12:35:38Z
dc.date2015-11-26T15:25:42Z
dc.date2015-06-26T12:35:38Z
dc.date2015-11-26T15:25:42Z
dc.date.accessioned2018-03-28T22:34:29Z
dc.date.available2018-03-28T22:34:29Z
dc.identifier
dc.identifierCiencia Rural. , v. 40, n. 11, p. 2332 - 2337, 2010.
dc.identifier1038478
dc.identifier
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-78650818539&partnerID=40&md5=7051396e560e3633881744e72cd2728d
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/90972
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/90972
dc.identifier2-s2.0-78650818539
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1260967
dc.descriptionBovine respiratory syncytial virus (BRSV) causes pneumonia in young cattle. Modified-live-virus (MLV) and inactivated vaccines are currently used for the control of clinical effects of BRSV infections in cattle. On the present research, the stimulation of specific anti-BRSV immunoglobulin isotypes was investigated, through the use of different commercially available adjuvants (Water-in-oil emulsion, Quil A, Aluminumhydroxide) in inbred mice (Balb/C and C57BL/6). BRSV antibodies were measured using an enzyme-linked immunosorbent assay (ELISA) and the results were compared to the antibody levels induced by immunization of animals using live-BRSV-virus. Water-in-oil emulsion and alumadjuvant preparations induced higher levels of IgG1 immunoglobulins, whereas Quil A favored the production of IgG2 antibodies, this last being a more appropriate response profile for the specific case of BRSV. Not using adjuvants resulted in poor levels of specific antibodies. The isotype profile of specific antibodies obtained varied greatly depending on the adjuvants used. This information may be useful for the formulation of more effective BRSV inactivated vaccines; however, these findings have to be confirmed in cattle.
dc.description40
dc.description11
dc.description2332
dc.description2337
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dc.languageen
dc.languagept
dc.publisher
dc.relationCiencia Rural
dc.rightsaberto
dc.sourceScopus
dc.titleAntibody Responses In Mice After Immunization With Inactivated Bovine Respiratory Syncytial Virus Using Different Adjuvants [respostas De Anticorpos Em Camundongos Após Imunização Com Vírus Respiratório Sincicial Bovino Inativado Utilizando Diferentes Adjuvantes]
dc.typeArtículos de revistas


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