The Difficult Patient: Drug Interaction And The Influence Of Concomitant Diseases On The Treatment Of Hypothyroidism [o Paciente Difícil: Interação Entre Drogas E Influência De Doenças Concomitantes No Tratamento Do Hipotiroidismo]

dc.creatorWard L.S.
dc.date2010
dc.date2015-06-26T12:34:46Z
dc.date2015-11-26T15:25:04Z
dc.date2015-06-26T12:34:46Z
dc.date2015-11-26T15:25:04Z
dc.date.accessioned2018-03-28T22:33:53Z
dc.date.available2018-03-28T22:33:53Z
dc.identifier
dc.identifierArquivos Brasileiros De Endocrinologia E Metabologia. , v. 54, n. 5, p. 435 - 442, 2010.
dc.identifier42730
dc.identifier
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-77956791809&partnerID=40&md5=0c9cf4230c20d0ca37e93d6a0e02f182
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/90845
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/90845
dc.identifier2-s2.0-77956791809
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1260826
dc.descriptionAlthough most hypothyroid patients do well with one single tablet of thyroxine daily, approximately 10% are dissatisfied and another important group of patients is difficult to control. We reviewed the most common causes for frequent-dose adjustment or high-dose requirement, including poor compliance with therapy and inadequate medication. Since these two causes have been ruled out, drug interaction and other concomitant diseases need to be investigated. Requirements of thyroxine increase in all conditions characterized by impaired gastric acid secretion. Proton-pump inhibitors, antacids and a long list of drugs may decrease thyroxine absorption. In addition, a series of diseases including celiac disease and chronic inflammatory intestinal diseases, as well as nutritional habits may be important in patient control. Finally, we mention the effects of a growing list of drugs and thyroid disruptors that may also affect thyroid hormone metabolism at many levels. Copyright© ABE&M todos os direitos reservados.
dc.description54
dc.description5
dc.description435
dc.description442
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dc.languagept
dc.publisher
dc.relationArquivos Brasileiros de Endocrinologia e Metabologia
dc.rightsaberto
dc.sourceScopus
dc.titleThe Difficult Patient: Drug Interaction And The Influence Of Concomitant Diseases On The Treatment Of Hypothyroidism [o Paciente Difícil: Interação Entre Drogas E Influência De Doenças Concomitantes No Tratamento Do Hipotiroidismo]
dc.typeArtículos de revistas


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