P-glycoprotein And Multidrug Resistance: Structure-activity Relationships Of Modulators [glicoproteína-p, Resistência A Múltiplas Drogas (mdr) E Relação Estrutura-atividade De Moduladores]

dc.creatorHuber P.C.
dc.creatorMaruiama C.H.
dc.creatorAlmeida W.P.
dc.date2010
dc.date2015-06-26T12:34:35Z
dc.date2015-11-26T15:24:54Z
dc.date2015-06-26T12:34:35Z
dc.date2015-11-26T15:24:54Z
dc.date.accessioned2018-03-28T22:33:46Z
dc.date.available2018-03-28T22:33:46Z
dc.identifier
dc.identifierQuimica Nova. , v. 33, n. 10, p. 2148 - 2154, 2010.
dc.identifier1004042
dc.identifier
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-78650559104&partnerID=40&md5=a4d99a264f7de6435b9973e614715922
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/90825
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/90825
dc.identifier2-s2.0-78650559104
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1260797
dc.descriptionMultidrug resistance, MDR is a major obstacle for cancer chemotherapy. MDR can be reversed by drugs that vary in their chemical structure and main biological activity. Many efforts have been done to overcome MDR based on studies of structure-activity relationships and in this review we summarize some aspects of MDR mediated by P-glycoprotein (P-gp), as the most experimentally and clinically tested form of drug resistance. The most significant MDR mechanisms revealed until now are shortly discussed. Physicochemical and structural properties of MDR modulators, measures of the MDR reversal, and QSAR studies are included.
dc.description33
dc.description10
dc.description2148
dc.description2154
dc.descriptionLongley, D.B., Johnston, P.G., (2005) J. Pathol., 205, p. 275
dc.descriptionHill, B., (1996) Int. J. Oncol., 9, p. 197
dc.descriptionMitscher, L.A., Pillai, S.P., Gentry, E.J., Shankel, D.M., (1999) Med. Res. Rev., 19, p. 477
dc.descriptionDewick, P.M., (2009) Medicinal Natural Products, a Biosynthetic Approach, , 3rd ed., Wiley: United Kingdom
dc.descriptionDietel, M., (1991) Pathol. Res. Pract., 187, p. 892
dc.descriptionBeck, W.T., (1990) Cancer Treat. Rev., 17, p. 11
dc.descriptionMorrow, C.S., Cowan, K.H., (1990) Cancer Cell., 2, p. 15
dc.descriptionHammond, J.R., Johnstone, R.M., Gros, P., (1989) Cancer Res., 49, p. 3867
dc.descriptionHannun, Y.A., (1977) Blood, 89, p. 1845
dc.descriptionSzakacs, G., Paterson, J.K., Ludwig, J.A., Booth-Genthe, C., Gottesman, M.M., (2006) Nat. Rev. Drug Discovery, 5, p. 219
dc.descriptionKessel, D., Bottenrill, V., Wodinsky, I., (1968) Cancer Res., 28, p. 938
dc.descriptionJones, P.M., George, A.M., (1998) J. Membr. Biol., 166, p. 133
dc.descriptionRobert, J., (1997) Drugs Fut, 22, p. 149
dc.descriptionJuliano, R.L., Ling, V., (1976) Biochim. Biophys. Acta, 455, p. 152
dc.descriptionRuetz, S., Gros, P., (1994) Cell., 77, p. 1071
dc.descriptionBorst, P., Evers, R., Kool, M., Wijnholds, J., (2000) J. Nat. Cancer Inst., 92, p. 1295
dc.descriptionHipfner, D.R., Deeley, R.G., Cole, S.P.C., (1999) Biochim. Biophys. Acta, 1461, p. 359
dc.descriptionLitman, T., Druley, T.E., Stein, W.D., Bates, S.E., (2001) Cell. Mol. Life Sci., 58, p. 931
dc.descriptionDeeley, R.G., Cole, S.P.C., (1997) Cancer Biol., 8, p. 193
dc.descriptionGatti, L., Beretta, G.L., Cossa, G., Zunino, F., Perego, P., (2009) Mini-Rev. Med. Chem., 9, p. 1102
dc.descriptionGottesmann, M.M., Pastan, I., (1993) Annu. Rev. Biochem., 62, p. 385
dc.descriptionKing, M., Su, W., Chang, A., Zuckerman, A., Pasternak, G.W., (2001) Nature Neurosci., 4, p. 268
dc.descriptionLiu, X.D., Liu, G.Q., (2001) Acta Pharmacol. Sin., 22, p. 111
dc.descriptionRaviv, Y., Pollard, H.B., Bruggemann, E.P., Pastan, I., Gottesmann, M.M., (1990) J. Biol. Chem., 265, p. 3975
dc.descriptionStein, W.D., (1977) Phys. Rev., 77, p. 545
dc.descriptionHiggins, C.F., (1994) Cell., 79, p. 393
dc.descriptionDawson, R.J.P., Locher, K.P., (2006) Nature, 443, p. 180
dc.descriptionStenham, D.R., Campbell, J.D., Sansom, M.S.P., Higgins, C.F., Kerr, I.D., Linton, K.J., (2003) FASEB J., 17, p. 2287
dc.descriptionLocher, K.P., Lee, A.T., Rees, D.C., (2002) Science, 296, p. 1091
dc.descriptionHollenstein, K., Frei, K.P., Locher, K.P., (2007) Nature, 446, p. 213
dc.descriptionPinkett, H.W., Lee, A.T., Lum, P., Locher, K.P., Rees, D.C., (2007) Science, 315, p. 373
dc.descriptionOldham, M.L., Khare, D., Quiocho, F.A., Davidson, A.L., Chen, J., (2007) Nature, 450, p. 515
dc.descriptionRosenberg, M.F., Kamis, A.B., Callaghan, R., Higgins, C.F., Ford, J., (2003) J. Biol. Chem., 278, p. 8294
dc.descriptionLee, J.-Y., Urbatsch, I.L., Senior, A.E., Wilkens, S., (2008) J. Biol. Chem., 283, p. 5769
dc.descriptionAller, S.G., Yu, J., Ward, A., Weng, Y., Chittaboina, S., Zhuo, R., Harrell, P.M., Chang, G., (2009) Science, 323, p. 1718
dc.descriptionLoo, T.W., Bartlett, M.C., Clarke, D.M., (2003) J. Biol. Chem., 278, p. 39706
dc.descriptionZamora, J.M., Pearce, H.L., Beck, W.T., (1988) Biochem. Pharmacol., 33, p. 454
dc.descriptionPajeva, I.K., Wiese, M., (1997) QSAR, 16, p. 1
dc.descriptionWiese, M., Pajeva, I.K., (2001) Curr. Med. Chem., 8, p. 685
dc.descriptionBiedler, J.R., Riehm, H., (1970) Cancer Res., 30, p. 1174
dc.descriptionSelassie, C.D., Hansch, C., Khwaja, T.A., (1990) J. Med. Chem., 33, p. 1914
dc.descriptionUeda, K., Taguchi, Y., Morishima, M.S., (1997) Cancer Biol., 8, p. 151
dc.descriptionRauch, C., Farge, E., (2000) Biophys. J., 78, p. 3036
dc.descriptionRauch, C., Pluen, A., (2007) Eur. Biophys. J., 36, p. 121
dc.descriptionRauch, C., (2009) Eur. Biophys. J., 38, p. 537
dc.descriptionEkins, S., Kim, R.B., Leake, B.F., Dantzig, A.H., Schuetz, E.G., Lan, L.-B., Yasuda, K.Y., Wrighton, S.A., (2002) Mol. Pharmacol., 61, p. 964
dc.descriptionSeelig, A., (1998) Int. J. Clin. Pharmacol. Ther., 36, p. 54
dc.descriptionRobert, J., Jarry, C., (2003) J. Med. Chem., 46, p. 4805
dc.descriptionUeda, K., Okamura, N., Hirai, M., Tanigawara, Y., Saeki, T., Kioka, N., Komano, T., Hori, R., (1992) J. Biol. Chem., 267, p. 24248
dc.descriptionEcker, G., Huber, M., Schmid, D., Chiba, P., (1999) Mol. Pharmacol., 56, p. 791
dc.descriptionGopinath, V.S., Thimmaiah, P., Thimmaiah, K.N., (2008) Bioorg. Med. Chem., 16, p. 474. , Um exemplo de protocolo pode ser encontrado em
dc.descriptionJekerle, V., Klinkhammer, W., Scollard, D.A., Breitbach, K., Reilly, R.M., Piquette-Miller, M., Wiese, M., (2006) Int. J. Cancer, 119, p. 414
dc.descriptionRamalhete, C., Molnar, J., Silva, M., Rosário, V.E., Ferreira, M.-J.U., (2009) Bioorg. Med. Chem., 17, p. 6942
dc.descriptionDhainaut, A., Regnier, G., Atassi, C., Pierre, A., Leonce, S., Kraus-BeRthier, L., Prost, J.-F., (1992) J. Med. Chem., 35, p. 2481
dc.descriptionSafa, A.R., (1999) Drug Res. Updates, 2, p. 371
dc.descriptionTaub, M.E., Podila, L., Almeida, I., (2005) Drug Metab. Dispos, 33, p. 1679
dc.descriptionFord, J.M., Bruggeman, E.P., Pastan, I., Gottesmann, M., Hait, W.N., (1990) Cancer Res., 50, p. 1748
dc.descriptionPearce, H.L., Winter, M.A., Beck, W.T., (1990) Adv. Enzyme Regul, 30, p. 357
dc.descriptionThomas, H., Coley, H.M., (2003) Cancer Control, 10, p. 159
dc.descriptionDey, S., (2000) Curr. Opin. Inv. Drugs, 3, p. 818
dc.descriptionRago, R.P., Einstein, A., Lush, R., Beer, T.M., Ko, Y.J., Henner, W.D., Bubley, G., Dalton, V.S., (2003) Cancer Chemother. Pharmacol., 51, p. 297
dc.descriptionMinderman, H., O'Loughlin, K.L., Pendyala, L., Baer, M.R., (2004) Clin. Cancer Res., 10, p. 1826
dc.descriptionKaiser, D., Terfloth, L., Kopp, S., Schulz, J., De Laet, R., Chiba, P., Ecker, G.F., Gasteiger, J., (2007) J. Med. Chem., 50, p. 1698
dc.descriptionFerrer-Montiel, A., Messeguer, A., Ferragut, J.A., Pérez-Payá, E., Masip, I., Cortés, N., Abdad-Merin, M.J., (2005) J. Pharmacol. Exp. Ther., 313, p. 112
dc.descriptionBisi, A., Gobbi, S., Rampa, A., Belluti, F., Piazzi, L., Valenti, P., Gyemant, N., Molnár, J., (2006) J. Med. Chem., 49, p. 3049
dc.descriptionHuber, P.C., Pettenazzi, M.C.R., Kohn, L.K., Tormena, C.F., Almeida, W.P., (2009) 10th Tetrahedron. Symposium, , Paris, France
dc.descriptionTraunecker, H.C., Stevens, M.C., Kerr, M.C., Ferry, D.R., (1999) Br. J. Cancer, 81, p. 942
dc.descriptionSparreboom, A., Plantings, A.S., Jewell, R.C., Van Der Gaast, A., De Bruijn, P., Loos, W.J., Nooter, K., Verweij, J., (1999) Anti-cancer Drugs, 10, p. 719
dc.descriptionPusztai, L., Wagner, P., Ibrahim, N., Rivera, E., Theriault, R., Booser, D., Symmans, F.W., Hortobagyi, G.N., (2005) Cancer, 104, p. 682
dc.descriptionWalker, J., Martin, C., Callaghan, R., (2004) Eur. J. Cancer, 40, p. 594. , e referências citadas
dc.descriptionMcDevitt, C.A., Callaghan, R., (2007) Pharmacol. Ther., 113, p. 429
dc.descriptionColafubo, N.A., Berardi, F., Cantore, M., Perrone, M.G., Contino, M., Inglese, C., Niso, M., Paradiso, A., (2008) Bioorg. Med. Chem., 16, p. 362
dc.descriptionTalegaonkar, S., Khar, R.K., Jaggi, M., Akhtar, N., Bansal, T., (2009) DDT, 14, p. 1067
dc.descriptionChavanpatil, M.D., Patil, Y., Panyam, J., (2006) Int. J. Pharm., 320, p. 150
dc.descriptionChavanpatil, M.D., Khdair, A., Gerard, B., Bachmeier, C., Miller, D.W., Shekhar, M.P.V., Panyam, J., (2007) Mol. Pharmacol., 4, p. 730
dc.descriptionPatil, Y., Sadhukha, T., Ma, L., Panyam, J., (2009) J. Controlled Release, 136, p. 21
dc.descriptionTachibana, T., Kitamura, S., Kato, M., Mitsui, T., Shirasaka, Y., Yamashita, S., Sugiyama, Y., (2010) Pharm. Res., 27, p. 442
dc.descriptionSiarheyeva, A., Liu, R., Sharom, F.J., (2010) J. Biol. Chem., 285, p. 7575
dc.descriptionBorska, S., Sopel, M., Chmielewska, M., Zabel, M., Dziegiel, P., (2010) Molecules, 15, p. 857
dc.descriptionSun, L.-R., Cui, S.-X., Qu, X.-J., (2010) Drugs Fut, 34, p. 53
dc.descriptionRiveiro, M.E., De Kimpe, N., Moglioni, A., Vazquez, R., Monczor, F., Shayo, C., Davio, C., (2010) Curr. Med. Chem., 17, p. 1325
dc.descriptionSingh, P., Kaur, J., Bhardwaj, A., (2010) Eur. J. Med. Chem., 45, p. 1256
dc.descriptionColabufo, N.A., Berardi, F., Cantore, M., Contino, M., Inglese, C., Niso, M., Perrone, R., (2010) J. Med. Chem., 53, p. 1883
dc.languagept
dc.publisher
dc.relationQuimica Nova
dc.rightsaberto
dc.sourceScopus
dc.titleP-glycoprotein And Multidrug Resistance: Structure-activity Relationships Of Modulators [glicoproteína-p, Resistência A Múltiplas Drogas (mdr) E Relação Estrutura-atividade De Moduladores]
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución