| dc.creator | Zavan B. | |
| dc.creator | do Amarante Paffaro A.M. | |
| dc.creator | Joazeiro P.P. | |
| dc.creator | Yamada A.T. | |
| dc.creator | Paffaro Jr. V.A. | |
| dc.date | 2012 | |
| dc.date | 2015-06-25T20:27:37Z | |
| dc.date | 2015-11-26T15:24:20Z | |
| dc.date | 2015-06-25T20:27:37Z | |
| dc.date | 2015-11-26T15:24:20Z | |
| dc.date.accessioned | 2018-03-28T22:33:15Z | |
| dc.date.available | 2018-03-28T22:33:15Z | |
| dc.identifier | 9781622572984 | |
| dc.identifier | Fibronectin: Current Concepts In Structure, Function And Pathology. Nova Science Publishers, Inc., v. , n. , p. 207 - 212, 2012. | |
| dc.identifier | | |
| dc.identifier | | |
| dc.identifier | http://www.scopus.com/inward/record.url?eid=2-s2.0-84892333763&partnerID=40&md5=ea4dc09a3a88cc1e6e15de21cc3a54a6 | |
| dc.identifier | http://www.repositorio.unicamp.br/handle/REPOSIP/90788 | |
| dc.identifier | http://repositorio.unicamp.br/jspui/handle/REPOSIP/90788 | |
| dc.identifier | 2-s2.0-84892333763 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1260668 | |
| dc.description | Fibronectin is an extracellular matrix component which has a crucial role in the establishment of a successful pregnancy. In this respectit plays an important function in cell migration. Uterine Natural Killer cells are the dominant lymphocytes found in the pregnant mammalian uterus. Studies have identified four differentiation stages of mouse uNK cells based on Dolichos biflorus agglutinin lectin cytochemistry. These differ-rentiated cells are distributed in preferential regions in the uterus throughout pregnancy. One function of these cells is the release of cytokines such as IFN-γ leading to spiral artery dilation and the maintenance of decidual integrity.Therefore these cells are essential for the normal development of decidua and placenta. When integrin expression on uNK cells was investigated in mouse uterine sections from gestation day 6 to 17it was found thata5, a6 and ß7 integrins were expressed in cells from gestation day 8 to 10 but not after gd12. Lamininwas expressed only on the antimesometrial side. ß7 integrinis an active receptor for VCAM-1 or MAdCAM-1 expressed by endothelial cells and this function promotes extra vasation of uNK cells through blood vessel walls. The absence of laminin closed to uNK cells suggests that these cells are not dependent on laminin and a6 integrin for their establishment within the extracellular matrix. However, fibronectin is present at gestation day 6 to 10 around uNK cells from the myometrium and the endometrial-myometrial junction. No staining for fibronectin was seen in the decidualized and non-decidualized endometrium near the placenta. Our results suggest that fibronectin appears to support uNK migration, proliferation, differentiation and survival in the uterus by binding toa5 integrin. The loss of a5 integrin ligation by the down regulation of fibronectin could inhibit these cellular events and perhaps unligated a5 can activelyinitiate apoptosis, possibly via a caspase 8-dependent pathway. This process has been described asintegrin-mediated cell death. © 2012 Nova Science Publishers, Inc. All rights reserved. | |
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| dc.description | 207 | |
| dc.description | 212 | |
| dc.description | Stewart, I., Peel, S., Granulated metrial gland cells in the virgin and early pregnant mouse uterus (1981) J. Anat., 133, pp. 535-54l | |
| dc.description | King, A., Loke, Y.W., On the nature and function of human uterine granular lymphocytes (1991) Immunol. Today., 12 (12), pp. 432-435. , Dec | |
| dc.description | Croy, B.A., Kiso, Y., Granulated metrial gland cells, a natural subset of the pregnant murine uterus (1993) Microsc. Res. Tech., 25, pp. 189-200 | |
| dc.description | Paffaro, Jr.V.A., Bizinotto, M.C., Joazeiro, P.P., Yamada, A.T., Subset Classification Of Mouse Uterine Natural Killer Cells By DBA Lectin Reactivity (2003) Placenta., 24, p. 479 | |
| dc.description | Bulmer, J.N., Lash, G.E., Human uterine natural killer cells: a reappraisal (2005) Mol. Immunol., 42, pp. 511-521 | |
| dc.description | Dickson, A.D., Bulmer, D., The fine structure of cells in the rat metrial gland (1971) J. Anat., 108, pp. 123-133 | |
| dc.description | Croy, B.A., Guimond, M.J., Luross, J., Hahnel, A., Wang, B., Van-Den Heuve, M., terine Natural Killer Cells do not Require Interleukin for Differentiation or Maturation (1997) Am. J. Reprod. Immunol., 37, p. 463 | |
| dc.description | Stewart, I., An investigation into the differentiation of granulated metrial gland cells in the early pregnant mouse uterus (1983) J. Anat., 137, pp. 85-93 | |
| dc.description | Peel, S., Stewart, I., Rat granulated metrial gland cells differentiate in pregnant chimeric mice and may be cytotoxic for mouse trophoblast (1989) Cell Differ. Develop., 28, pp. 55-64 | |
| dc.description | Parr, E.L., Parr, M.B., Zheng, L.M., Young, J.D.E., Mouse granulated metrial gland cells originated by local activation of uterine natural killer lymphocytes (1991) Biol. Reprod., 44, pp. 834-841 | |
| dc.description | Van Den Heuvel, M., McBey, B.A., Hahnel, A.C., Croy, B.A., An analysis of the uterine lynphocyte-derived hobridoma cell line GWM 1-2 for expression of receptor for estrogen, progesterone and interleikin 2 (1996) J. Reprod. Immunol., 31, pp. 37-50 | |
| dc.description | Croy, B.A., Ashkar, A.A., Foster, R.A., Disanto, J.P., Magram, J., Carson, D., Gendler, S.J., Guimond, M.J., Histological studies of gene-ablated mice support important functional roles for natural killer cells in the uterus during pregnancy (1997) J. Reprod. Immunol., 35, pp. 111-133 | |
| dc.description | Hunt, J.S., Miller, L., Vassmer, D., Croy, B.A., Expression of the inducible nitric oxide synthase gene in mouse uterine leukocytes and potential relationships with uterine function during pregnancy (1997) Biol. Reprod., 57, p. 827 | |
| dc.description | Ashkar, A.A., Croy, B.A., Interferon-gamma contributes to the normalcy of murine pregnancy (1999) Biol. Reprod., 61, p. 493 | |
| dc.description | Ashkar, A.A., Di Santo, J.P., Croy, B.A., Interferon gamma contributes to initiation of uterine vascular modification, decidual integrity, and uterine natural killer cell maturation during normal murine pregnancy (2000) J. Exp. Med., 192, p. 259 | |
| dc.description | Koopman, L.A., Kopcow, H.D., Rybalov, B., Boyson, J.E., Orange, J.S., Schatz, F., Masch, R., Strominger, J.L., Human decidual natural killer cells are a unique NK cell subset with immunomodulatory potential (2003) J. Exp. Med., 198, pp. 1201-1212. , Oct 20 | |
| dc.description | Zavan, B., Paffaro, A.M., Joazeiro, P.P., Yamada, A.T., Paffaro, Jr.V.A., Immuno-cytochemical studies of adhesion molecules on mouse uNK cells and their extracellular matrix ligands during mouse pregnancy (2010) Anat. Rec., 293, pp. 1081-1088 | |
| dc.description | Zavan, B., Carvalho, C.C., Rossi J.r, .W.C., Paffaro, A.M.A., Paffaro J.r, .V.A., Splenectmy delays uterine natural killer cell recruitment to implantation sites and prolongs pregnancy in mice (2012) Anat. Rec., 295, pp. 1221-1228 | |
| dc.description | Rider, V., Carlone, D.L., Witrock, D., Cai, C., Oliver, N., Uterine fibronectin mRNA content and localization are modulated during implantation (1992) Dev. Dyn., 195, pp. 1-14 | |
| dc.description | Abrahamsohn, P.A., Zorn, T.M.T., Implantation and decidualization in rodents (1993) J. Exp. Zool., 266, pp. 603-628 | |
| dc.description | Varner, J.A., Emerson, D.A., Juliano, R.L., Integrin alpha 5 beta 1 expression negatively regulates cell growth: reversal by attachment to fibronectin (1995) Mol. Biol. Cell., 6, pp. 725-740 | |
| dc.description | Kim, S., Bell, K., Mousa, S.A., Varner, J.A., Regulation of angiogenesis in vivo by ligation of integrin alpha5beta1 with the central cell-binding domain of fibronectin (2000) Am. J. Pathol., 156, pp. 1345-1362 | |
| dc.description | Plath, T., Detjen, K., Welzel, M., von Marschall, Z., Murphy, D., Schirner, M., Wiedenmann, B., Rosewicz, S., A novel function for the tumor suppressor p16(INK4a): induction of anoikis via upregulation of the alpha(5)beta(1) fibronectin receptor (2000) J. Cell Biol., 150, pp. 1467-1478 | |
| dc.description | Stupack, D.G., Puente, X.S., Boutsaboualoy, S., Storgard, C.M., Cheresh, D.A., Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrins (2001) J. Cell Biol., 155, pp. 459-470 | |
| dc.language | en | |
| dc.publisher | Nova Science Publishers, Inc. | |
| dc.relation | Fibronectin: Current Concepts in Structure, Function and Pathology | |
| dc.rights | fechado | |
| dc.source | Scopus | |
| dc.title | Evidence For Fibronectin Role On Uterine Natural Killer Cells Migration, Proliferation, Differentiation And Survival During Pregnancy | |
| dc.type | Capítulos de libros | |
