Sequential Extraction Of Bioactive Compounds From Melia Azedarach L. In Fixed Bed Extractor Using Co2, Ethanol And Water

dc.creatorBitencourt R.G.
dc.creatorQueiroga C.L.
dc.creatorDuarte G.H.B.
dc.creatorEberlin M.N.
dc.creatorKohn L.K.
dc.creatorArns C.W.
dc.creatorCabral F.A.
dc.date2014
dc.date2015-06-25T17:49:38Z
dc.date2015-11-26T15:24:19Z
dc.date2015-06-25T17:49:38Z
dc.date2015-11-26T15:24:19Z
dc.date.accessioned2018-03-28T22:33:14Z
dc.date.available2018-03-28T22:33:14Z
dc.identifier
dc.identifierJournal Of Supercritical Fluids. Elsevier, v. 95, n. , p. 355 - 363, 2014.
dc.identifier8968446
dc.identifier10.1016/j.supflu.2014.09.027
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84908208569&partnerID=40&md5=91c4afca12fe84dfb79cfaa303f42c95
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/85686
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/85686
dc.identifier2-s2.0-84908208569
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1260665
dc.descriptionMelia azedarach L. is a plant with wide use in folk medicine since it contains many bioactive compounds ofinterest. The present study aimed to extract bioactive compounds from M. azedarach fruits by a sequentialprocess in fixed bed using various solvent mixtures. Extractions were performed at 50°C and 300 bar infour sequential steps using supercritical CO2(scCO2), scCO2/ethanol, pure ethanol, and ethanol/watermixture as solvents, respectively. The efficacy of the extraction process was evaluated by extraction yieldand kinetics, and analysis of extracts by: (1) thin layer chromatography (TLC), (2) phenolics content,(3) reduction of surface tension of water, (4) gas chromatography (GCMS), (5) electrospray ionizationmass spectrometry (ESIMS) and (6) antiviral activity. The overall extraction yield reached 45% andTLC analysis showed extracts with different composition. extract obtained from CO2/ethanol mixture(SCEE) exhibited the greatest ability to reduce surface tension of water from 72.4 mN m?1[1] of purewater to 26.9 mN m?1of an aqueous solution of 40 g L?1. The highest phenolics contents were observedin both the hydroalcoholic extract and scCO2/ethanolic extract. Volatile oils were not detected in thesupercritical extracts by GCMS. MS analyses identified the fatty acids: linoleic, palmitic and myristicacid in the supercritical extract (SCE), and the phenolics: caffeic acid and malic acid in the other extracts.In addition, SCE and SCEE extracts showed significant inhibition percentage against Herpes Simplex VirusType 1. The extraction process proposed in the present study produced extracts with significant potentialfor application in food and pharmaceutical industries.
dc.description95
dc.description
dc.description355
dc.description363
dc.descriptionBitencourt, R.G., Queiroga, C.L., Montanari Junior, I., Cabral, F.A., Fractionated extraction of saponins from Brazilian ginseng by sequential process using supercritical CO2, ethanol and water (2014) J. Supercritical Fluids, 92, pp. 272-281
dc.descriptionAl-Rubae, A.Y., The potential uses of Melia azedarach L. As pesticidal and medicinal plant, review (2009) American-Eurasian J. Sustainable Agriculture, 3, pp. 185-194
dc.descriptionLorenzi, H., (2003) Árvores Exóticas No Brazil: Madeireiras, Ornamentais e Aromáticas, , Institituto Plantarum de Estudos da Flora Nova Odessa, SP
dc.descriptionWachsman, M., Martino, V., Gutkind, G.O., Coussio, J.D., Coto, C.E., De Torres, R.A., Antiviral activity of a Melia azedarach plant extract (1982) Fitoterapia, 53, pp. 167-170
dc.descriptionAndrei, G.M., Lampuri, J.S., Coto, C.E., De Torres, R.A., An antiviral factor from Meliaazedarach L. Prevents Tacaribe virus encephalitis in mice (1986) Experientia, 42, pp. 843-845
dc.descriptionWachsman, M.B., Castilla, V., Coto, C.E., Inhibition of foot and mouth disease virus (FMDV) uncoating by a plant-derived peptide isolated from Melia azedarach L. Leaves (1998) Archives of Virology, 143, pp. 581-590
dc.descriptionKhan, A.V., Ahmed, Q.U., Mir, M.R., Shukla, I., Khan, A.A., Antibacterial efficacy of the seed extracts of Melia azedarach against some hospital isolated human pathogenic bacterial strains (2011) Asian Pacific J. Tropical Biomedicine, 1, pp. 452-455
dc.descriptionCarpinella, M.C., Miranda, M., Almirón, W.R., Ferrayoli, C.G., Almeida, F.L., Palacios, S.M., In vitro pediculicidal and ovicidal activity of an extract and oil from fruits of Melia azedarach L (2007) J. American Academy of Dermatology, 56, pp. 250-256
dc.descriptionMcKenna, M.M., Abou-Fakhr Hammad, E.M., Farran, M.T., Effect of Melia azedarach (Sapindales: Meliaceae) fruit extracts on Citrus Leafminer Phyllocnistis citrella (Lepidoptera: Gracillariidae) (2013) SpringerPlus, 2, pp. 144-150
dc.descriptionScapinello, J., Ribeiros, M.L., Tomazelli, O., Jr., Chiaradia, L.A., Vladimir, J., Oliveira, J.D.M., Effects of supercritical CO2 extracts of Melia azedarach L. on the control of fall armyworm (Spodoptera frugiperda) (2014) J. Supercritical Fluids, 86, pp. 100-107
dc.descriptionAkihisa, T., Pan, X., Nakamura, Y., Kikuchi, T., Takahashi, N., Matsumoto, M., Ogihara, E., Tokuda, H., Limonoids from the fruits of Melia azedarach and their cytotoxic activities (2013) Phytochemistry, 89, pp. 59-70
dc.descriptionYuan, C.M., Zhang, Y., Tang, G.H., Li, Y., He, H.P., Li, S.F., Hou, L., Hao, X.J., Cytotoxic limonoids from Melia azedarach (2013) Planta Medica, 79, pp. 163-168
dc.descriptionAoudia, H., Oomah, B.D., Zaidi, F., Zaidi-Yahiaoui, R., Drover, J.C.G., Harrison, J.E., Phenolics, antioxidant and anti-inflammatory activities of Melia azedarach extracts (2013) International J. Applied Research in Natural Products, 6, pp. 19-29
dc.descriptionMatias, R., Sólon, S., Resende, U.M., Gomes, A., Koller, W.W., Melia azedarach, uso popular x estudos químico e farmacológico: Breve revisão (2002) Ensaios e Ciência, 6, pp. 91-121
dc.descriptionYang, Y., Xiao, Y., Liu, B., Fang, X., Yang, W., Xu, J., Comparison of headspace solid-phase microextraction with conventional extraction for the analysis of the volatile components in Melia azedarach (2011) Talanta, 86, pp. 356-361
dc.descriptionAoudia, H., Ntalli, N., Aissani, N., Yahiaoui-Zaidi, R., Caboni, P., Nematotoxic phenolic compounds from Melia azedarach against Meloidogyne incognita (2012) J. Agricultural and Food Chemistry, 60, pp. 11675-11680
dc.descriptionOrhan, I.E., Guner, E., Ozturk, N., Senol, F.S., Erdem, S.A., Kartal, M., Sener, B., Enzyme inhibitory and antioxidant activity of Melia azedarach L. Naturalized in Anatolia and its phenolic acid and fatty acid composition (2012) Industrial Crops and Products, 37, pp. 213-218
dc.descriptionChiffelle, I.G., Huerta, A.F., Lizana, D.R., Physical and chemical characterization of Melia azedarach L. Fruit and leaf for use as botanical insecticide (2009) Chilean J. Agricultural Research, 69, pp. 38-45
dc.descriptionSeffrin, R.C.A.S., Corrêa Costa, E., Borges, L., Corralo Borges, V., Do Nascimento, P.C., Bastos Dequech, S.T., Sausen, C.D., Extratos aquosos de frutos verdes de Melia azedarach L. Var. Azedarach: Investigação da presença de cianeto e avaliação toxicológica (2011) Biotemas, 21, pp. 143-147
dc.descriptionBrunner, G., Supercritical fluids: Technology and application to food processing (2005) J. Food Engineering, 67, pp. 21-33
dc.descriptionSeabra, I.J., Braga, M.E.M., Batista, M.T., De Sousa, H.C., Effect of solvent (CO2/ethanol/H2O) on the fractionated enhanced solvent extraction of anthocyanins from elderberry pomace (2010) J. Supercritical Fluids, 54, pp. 145-152
dc.descriptionPaula, J.T., Paviani, L.C., Foglio, M.A., Sousa, I.M.O., Cabral, F.A., Extraction of anthocyanins from Arrabidaea chica in fixed bed using CO2 and CO2/ethanol/water mixtures as solvents (2013) J. Supercritical Fluids, 81, pp. 33-41
dc.descriptionGarmus, T.T., Paviani, L.C., Queiroga, C.L., Magalhães, P.M., Cabral, F.A., Extraction of phenolic compounds from pitanga (Eugenia uniflora L.) leaves by sequential extraction in fixed bed extractor using supercritical CO2, ethanol and water as solvents (2014) J. Supercritical Fluids, 86, pp. 4-14
dc.descriptionPaula, J.T., Paviani, L.C., Foglio, M.A., Sousa, I.M., Duarte, G.H., Jorge, M.P., Eberlin, M.N., Cabral, F.A., Extraction of anthocyanins and luteolin from Arrabidaea chica by sequential extraction in fixed bed using supercritical CO2, ethanol and water as solvents (2014) J. Supercritical Fluids, 86, pp. 100-107
dc.description(1997) Method of Determining and Expressing Fineness of Feed Materials by Sieving, , American Society of Agricultural and Biological Engineers St. Joseph, MI
dc.descriptionA O.A.C., (1997) Official Methods of Analysis, 16. , Association of Official Analytical Chemists Washington, DC
dc.descriptionOil Chemist'S Society (aocs), (1998) Official Methods and Recommended Practices of the American Oil Chemist's Society, 1, p. 1. , sixth ed. AOCS Press Champaign, IL (ca 23-55)
dc.descriptionSingleton, V.L., Orthofer, R., Lamuela-Raventós, R.M., Analysis of total phenols and other oxidation substrates and antioxidants by means of folin-ciocalteu reagent (1999) Methods in Enzymology, 299, pp. 152-178. , Academic Press
dc.descriptionZhishen, J., Mengcheng, T., Jianming, W., The determination of flavonoid contents in mulberry and their scavenging effects on superoxide radicals (1999) Food Chemistry, 64, pp. 555-559
dc.descriptionNicoll, M.P., Efstathiou, S., Expression of the herpes simplex virus type 1 latency-associated transcripts does not influence latency establishment of virus mutants deficient for neuronal replication (2013) J. General Virology, 94, pp. 2489-2494
dc.descriptionYousefi, I., (2011) Selective Activation of Unfolded Protein Response (UPR) by Herpes Simplex Virus Type 1 (HSV-1) in Permissive and Non Permissive Cells, , University of Saskatchewan Saskatoon (Masters Thesis)
dc.descriptionRadford, A.D., Addie, D., Belák, S., Boucraut-Baralon, C., Egberink, H., Frymus, T., Gruffydd-Jones, T., Horzinek, M.C., Feline calicivirus infection: ABCD guidelines on prevention and management (2009) J. Feline Medicine and Surgery, 11, pp. 556-564
dc.descriptionBae, J., Schwab, K.J., Evaluation of murine norovirus, feline calicivirus, poliovirus, and MS2 as surrogates for human norovirus in a model of viral persistence in surface water and groundwater (2008) Applied and Environmental Microbiology, 74, pp. 477-484
dc.descriptionGlass, R.I., Parashar, U.D., Estes, M.K., Norovirus gastroenteritis (2009) New England J. Medicine, 361, pp. 1776-1785
dc.descriptionShionoiri, N., Sato, T., Fujimori, Y., Nakayama, T., Nemoto, M., Matsunaga, T., Tanaka, T., Investigation of the antiviral properties of copper iodide nanoparticles against feline calicivirus (2012) J. Bioscience and Bioengineering, 113, pp. 580-586
dc.descriptionReed, J.H., Muench, H., A simple method for estimating fifty percent endpoints (1938) American J. Tropical Medicine and Hygiene, 27, pp. 493-496
dc.descriptionKoseki, I., Simoni, I.C., Nakamura, I.T., Noronha, A.B., Costa, S.S., Antiviral activity of plant extracts against aphtovirus, pseudorabies virus and pestivirus in cell cultures (1990) Microbios Letters, 44, pp. 19-30
dc.descriptionSovová, H., Rate of the vegetable oil extraction with supercritical CO2 - I. Modelling of extraction curves (1994) Chemical Engineering Science, 49, pp. 409-414
dc.descriptionVasconcelos, E.A.F., Barbosa, R.M., Medeiros, M.G.F., Moura, T.F.A.L., Influência do processo extrativo, solvente e tamanho da partícula do material vegetal no teor de sólidos totais da solução extrativa da Schinus terebinthifollus Raddl (2005) Revista Fitos, 1, pp. 71-79
dc.descriptionJung, P.H., Da Silveira, A.C., Nieri, E.M., Potrich, M., Da Silva, E.R.L., Refatti, M., Atividade Inseticida de Eugenia uniflora L. E Melia azedarach L. Sobre Atta laevigata Smith (2013) Floresta e Ambiente, 20, pp. 191-196
dc.descriptionNitschke, M., Pastore, G.M., Biossurfactantes: Propriedades e aplicações (2002) Química Nova, 25, pp. 772-776
dc.descriptionBehring, J.L., Lucas, M., Machado, C., Barcellos, I.O., Adaptação no método do peso da gota para determinação da tensão superficial: Um método simplificado para a quantificação da CMC de surfactantes no ensino da química (2004) Química Nova, 2760, pp. 492-495
dc.descriptionBarros, F.F.C., De Quadros, C.P., Maróstica, M., Pastore, G.M., Surfactina: Propriedades químicas, tecnológicas e funcionais para aplicações em alimentos (2007) Química Nova, 30, p. 409
dc.descriptionMitra, S., Dungan, S.R., Micellar properties of Quillaja saponin. 1. Effects of temperature, salt, and pH on solution properties (1997) J. Agricultural and Food Chemistry, 45, pp. 1587-1595
dc.descriptionDecroos, K., Vincken, J.P., Van Koningsveld, G.A., Gruppen, H., Verstraete, W., Preparative chromatographic purification and surfactant properties of individual soyasaponins from soy hypocotyls (2007) Food Chemistry, 101, pp. 324-333
dc.descriptionXiong, J., Guo, J., Huang, L., Meng, B., Ping, Q., Self-micelle formation and the incorporation of lipid in the formulation affect the intestinal absorption of Panax notoginseng (2008) International J. Pharmaceutics, 360, pp. 191-196
dc.descriptionRibeiro, B.D., Alviano, D.S., Barreto, D.W., Coelho, M.A.Z., Functional properties of saponins from sisal (Agave sisalana) and juá (Ziziphus joazeiro): Critical micellar concentration, antioxidant and antimicrobial activities (2013) Colloids and Surfaces A: Physicochemical and Engineering Aspects, 436, pp. 736-743
dc.descriptionStanimirova, R., Marinova, K., Tcholakova, S., Denkov, N., Stoyanov, S., Pelan, E., Surface rheology of saponin adsorption layers (2011) Langmuir, 27, pp. 12486-12498
dc.descriptionOrhan, I.E., Guner, E., Ozcelik, B., Senol, F.S., Caglar, S.S., Emecen, G., Kocak, O., Sener, B., Assessment of antimicrobial, insecticidal and genotoxic effects of Melia azedarach L. (chinaberry) naturalized in Anatolia (2012) International J. Food Sciences and Nutrition, 63, pp. 560-565
dc.descriptionMartinez-Correa, H.A., Magalhães, P.M., Queiroga, C.L., Peixoto, C.A., Oliveira, A.L., Cabral, F.A., Extracts from pitanga (Eugenia uniflora L.) leaves: Influence of extraction process on antioxidant properties and yield of phenolic compounds (2011) J. Supercritical Fluids, 55, pp. 998-1006
dc.descriptionWu, S.-B., Ji, Y.-P., Zhu, J.-J., Zhao, Y., Xia, G., Hu, Y.-H., Hu, J.-F., Steroids from the leaves of Chinese Melia azedarach and their cytotoxic effects on human cancer cell lines (2009) Steroids, 74, pp. 761-765
dc.descriptionWu, S.B., Bao, Q.Y., Wang, W.X., Zhao, Y., Xia, G., Zhao, Z., Zeng, H., Hu, J.F., Cytotoxic triterpenoids and steroids from the bark of Melia azedarach (2011) Planta Medica, 77, pp. 922-928
dc.descriptionHuang, R.C., Okamura, H., Iwagawa, T., Tadera, K., Nakatani, M., Azedarachin, C., A limonoid antifeedant from Melia azedarach (1995) Phytochemistry, 38, pp. 593-594
dc.descriptionSimoni, I.C., Evaluation of the antiviral activity of Brazilian cerrado plants against animal viruses (2007) Virus Reviews & Research, 12
dc.descriptionKaziyama, V.M., Fernandes, M.J.B., Simoni, I.C., Atividade antiviral de extratos de plantas medicinais disponíveis comercialmente frente aos herpesvírus suíno e bovino (2012) Revista Brazileira de Plantas Medicinais, 14, pp. 522-528
dc.descriptionUquiche, E., Del Valle, J.M., Ortiz, J., Supercritical carbon dioxide extraction of red pepper (Capsicum annuum L.) oleoresin (2004) J. Food Engineering, 65, pp. 55-66
dc.descriptionRahman, M.S., Perera, C.O., Chen, X.D., Driscoll, R.H., Potluri, P.L., Density, shrinkage and porosity of calamari mantle meat during air drying in a cabinet dryer as a function of water content (1996) J. Food Engineering, 30, pp. 135-145
dc.languageen
dc.publisherElsevier
dc.relationJournal of Supercritical Fluids
dc.rightsfechado
dc.sourceScopus
dc.titleSequential Extraction Of Bioactive Compounds From Melia Azedarach L. In Fixed Bed Extractor Using Co2, Ethanol And Water
dc.typeArtículos de revistas


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