Lipid Therapy With Two Agents In Ropivacaine-induced Toxicity: Experimental Study In Swine

dc.creatorBonfim M.R.
dc.creatorDe Simone Melo M.
dc.creatorDreyer E.
dc.creatorBorsoi L.F.A.
dc.creatorde Oliveira T.G.
dc.creatorUdelsmann A.
dc.date2012
dc.date2015-06-25T20:26:56Z
dc.date2015-11-26T15:23:12Z
dc.date2015-06-25T20:26:56Z
dc.date2015-11-26T15:23:12Z
dc.date.accessioned2018-03-28T22:32:14Z
dc.date.available2018-03-28T22:32:14Z
dc.identifier
dc.identifierRevista Brasileira De Anestesiologia. , v. 62, n. 5, p. 685 - 695, 2012.
dc.identifier347094
dc.identifier10.1016/S0034-7094(12)70167-8
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84866508838&partnerID=40&md5=0891602790daf45176a3d614ee463047
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/90614
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/90614
dc.identifier2-s2.0-84866508838
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1260462
dc.descriptionBackground and objective: Compare hemodynamic changes after ropivacaine-induced toxicity followed by treatment with two lipid emulsions in swine. Methods: Large White pigs were anesthetized with thiopental, followed by intubation, and kept on mechanical ventilation. Hemodynamic variables at rest were recorded with invasive pressure monitoring and pulmonary artery catheterization. After 30 minutes, 7mg.kg-1 ropivacaine were injected intravenously and new hemodynamic measurements were performed within one minute. The animals were then randomly allocated into three groups and received: 4mL.kg-1 saline solution, or 4mL.kg-1 lipid emulsion with long-chain triglycerides, or 4mL.kg-1 lipid emulsion with longand medium-chain triglycerides. Hemodynamic changes were reevaluated at 5, 10, 15, 20 and 30 minutes. Results: Ropivacaine-induced toxicity mainly caused a drop in blood pressure and cardiac index without significant changes in vascular resistance. Therapy with lipid emulsions restored blood pressure primarily through increased vascular resistance, as cardiac index showed no significant improvement. Lipid emulsion with medium-chain triglycerides caused a greater increase in vascular resistance, particularly pulmonary. Conclusion: In groups receiving lipid emulsions, hemodynamic results were better than in control group. There were no differences in systemic arterial pressure and cardiac index between animals receiving lipid emulsion with long-chain triglycerides and mixed long- and medium-chain triglycerides. © 2012 Elsevier Editora Ltda.
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dc.languageen
dc.publisher
dc.relationRevista Brasileira de Anestesiologia
dc.rightsfechado
dc.sourceScopus
dc.titleLipid Therapy With Two Agents In Ropivacaine-induced Toxicity: Experimental Study In Swine
dc.typeArtículos de revistas


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