dc.creator | Claudino M.A. | |
dc.creator | Fertrin K.Y. | |
dc.date | 2012 | |
dc.date | 2015-06-25T20:25:55Z | |
dc.date | 2015-11-26T15:22:33Z | |
dc.date | 2015-06-25T20:25:55Z | |
dc.date | 2015-11-26T15:22:33Z | |
dc.date.accessioned | 2018-03-28T22:31:47Z | |
dc.date.available | 2018-03-28T22:31:47Z | |
dc.identifier | | |
dc.identifier | Anemia. , v. 2012, n. , p. - , 2012. | |
dc.identifier | | |
dc.identifier | 10.1155/2012/723520 | |
dc.identifier | http://www.scopus.com/inward/record.url?eid=2-s2.0-84873863556&partnerID=40&md5=7f5afa0a63699b602144e3ea65fee2ad | |
dc.identifier | http://www.repositorio.unicamp.br/handle/REPOSIP/90571 | |
dc.identifier | http://repositorio.unicamp.br/jspui/handle/REPOSIP/90571 | |
dc.identifier | 2-s2.0-84873863556 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1260392 | |
dc.description | Sickle cell anemia is one of the best studied inherited diseases, and despite being caused by a single point mutation in the HBB gene, multiple pleiotropic effects of the abnormal hemoglobin S production range from vaso-occlusive crisis, stroke, and pulmonary hypertension to osteonecrosis and leg ulcers. Urogenital function is not spared, and although priapism is most frequently remembered, other related clinical manifestations have been described, such as nocturia, enuresis, increased frequence of lower urinary tract infections, urinary incontinence, hypogonadism, and testicular infarction. Studies on sickle cell vaso-occlusion and priapism using both in vitro and in vivo models have shed light on the pathogenesis of some of these events. The authors review what is known about the deleterious effects of sickling on the genitourinary tract and how the role of cyclic nucleotides signaling and protein kinases may help understand the pathophysiology underlying these manifestations and develop novel therapies in the setting of urogenital disorders in sickle cell disease. © 2012 Mário Angelo Claudino and Kleber Yotsumoto Fertrin. | |
dc.description | 2012 | |
dc.description | | |
dc.description | | |
dc.description | | |
dc.description | Herrick, C.J., The evolution of intelligence and its organs (1910) Science, 31 (784), pp. 7-18. , 2-s2.0-37049234750 | |
dc.description | Steinberg, M.H., Management of sickle cell disease (1999) New England Journal of Medicine, 340 (13), pp. 1021-1030. , DOI 10.1056/NEJM199904013401307 | |
dc.description | Kato, G.J., Gladwin, M.T., Evolution of novel small-molecule therapeutics targeting sickle cell vasculopathy (2008) Journal of the American Medical Association, 300 (22), pp. 2638-2646. , 2-s2.0-57449112518 10.1001/jama.2008.598 | |
dc.description | Conran, N., Franco-Penteado, C.F., Costa, F.F., Newer aspects of the pathophysiology of sickle cell disease vaso-occlusion (2009) Hemoglobin, 33 (1), pp. 1-16. , 2-s2.0-60749094795 10.1080/03630260802625709 | |
dc.description | Hebbel, R.P., Boogaerts, M.A.B., Eaton, J.W., Steinberg, M.H., Erythrocyte adherence to endothelium in sickle-cell anemia. A possible determinant of disease severity (1980) New England Journal of Medicine, 302 (18), pp. 992-995 | |
dc.description | Francis Jr., R.B., Johnson, C.S., Vascular occlusion in sickle cell disease: Current concepts and unanswered questions (1991) Blood, 77 (7), pp. 1405-1414. , 2-s2.0-0025881582 | |
dc.description | Diggs, L.W., Ching, R.E., Pathology of sickle cell anemia (1934) Southern Medical Journal, 27, pp. 839-845 | |
dc.description | Adeyoju, A.B., Olujohungbe, A.B.K., Morris, J., Yardumian, A., Bareford, D., Akenova, A., Akinyanju, O., O'Reilly, P.H., Priapism in sickle-cell disease | |
dc.description | incidence, risk factors and complications - An international multicentre study (2002) BJU International, 90 (9), pp. 898-902. , DOI 10.1046/j.1464-410X.2002.03022.x | |
dc.description | Nolan, V.G., Wyszynski, D.F., Farrer, L.A., Steinberg, M.H., Hemolysis-associated priapism in sickle cell disease (2005) Blood, 106 (9), pp. 3264-3267. , http://www.bloodjournal.org/cgi/reprint/106/9/3264, DOI 10.1182/blood-2005-04-1594 | |
dc.description | Bivalacqua, T.J., Burnett, A.L., Priapism: New concepts in the pathophysiology and new treatment strategies (2006) Current Urology Reports, 7 (6), pp. 497-502 | |
dc.description | Crane, G.M., Bennett Jr., N.E., Priapism in sickle cell anemia: Emerging mechanistic understanding and better preventative strategies (2011) Anemia, 2011, p. 6. , 297364 10.1155/2011/297364 | |
dc.description | Thought leader panel on evaluation and treatment of priapism. Report of the American Foundation for Urologic Disease (AFUD) thought leader panel for evaluation and treatment of priapism (2001) International Journal of Impotence Research, 15 (SUPPL.), pp. S39-S43. , American Foundation for Urologic Disease 2-s2.0-0035671356 | |
dc.description | Numan, F., Cantasdemir, M., Ozbayrak, M., Sanli, O., Kadioglu, A., Hasanefendioglu, A., Bas, A., Posttraumatic nonischemic priapism treated with autologous blood clot embolization (2008) Journal of Sexual Medicine, 5 (1), pp. 173-179. , 2-s2.0-37549051268 10.1111/j.1743-6109.2007.00560.x | |
dc.description | Burnett, A.L., Bivalacqua, T.J., Glucose-6-phosphate dehydrogenase deficiency: An etiology for idiopathic priapism? (2008) Journal of Sexual Medicine, 5 (1), pp. 237-240. , 2-s2.0-37549034987 10.1111/j.1743-6109.2007.00631.x | |
dc.description | Finley, D.S., Glucose-6-phosphate dehydrogenase deficiency associated stuttering priapism: Report of a case (2008) Journal of Sexual Medicine, 5 (12), pp. 2963-2966. , 2-s2.0-57449110148 10.1111/j.1743-6109.2008.01007.x | |
dc.description | Jin, Y.C., Gam, S.C., Jung, J.H., Hyun, J.S., Chang, K.C., Hyun, J.S., Expression and activity of heme oxygenase-1 in artificially induced low-flow priapism in rat penile tissues (2008) Journal of Sexual Medicine, 5 (8), pp. 1876-1882. , 2-s2.0-48949084667 10.1111/j.1743-6109.2008.00886.x | |
dc.description | Burnett, A.L., Pathophysiology of priapism: Dysregulatory erection physiology thesis (2003) Journal of Urology, 170 (1), pp. 26-34. , DOI 10.1097/01.ju.0000046303.22757.f2 | |
dc.description | Bivalacqua, T.J., Musicki, B., Kutlu, O., Burnett, A.L., New insights into the pathophysiology of sickle cell disease-associated priapism (2011) Journal of Sexual Medicine, 9, pp. 79-87. , 2-s2.0-79955644104 10.1111/j.1743-6109.2011.02288.x | |
dc.description | Dong, Q., Deng, S., Wang, R., Yuan, J., In vitro and in vivo animal models in priapism research (2011) Journal of Sexual Medicine, 8 (2), pp. 347-359. , 2-s2.0-79551484587 10.1111/j.1743-6109.2010.02052.x | |
dc.description | Chen, K.K., Chan, J.Y., Chang, L.S., Chen, M.T., Chan, S.H., Intracavernous pressure as an experimental index in a rat model for the evaluation of penile erection (1992) Journal of Urology, 147 (4), pp. 1124-1128. , 2-s2.0-0026842919 | |
dc.description | Lue, T.F., Expression of TGF-β-1 MRNA and ultrastructural alterations in pharmacologically induced prolonged penile erection in a canine model (1998) Journal of Urology, 160 (6), pp. 2263-2266 | |
dc.description | Munarriz, R., Park, K., Huang, Y.-H., Saenz De Tejada, I., Moreland, R.B., Goldstein, I., Traish, A.M., Reperfusion of ischemic corporal tissue: Physiologic and biochemical changes in an animal model of ischemic priapism (2003) Urology, 62 (4), pp. 760-764. , DOI 10.1016/S0090-4295(03)00484-9 | |
dc.description | Evliyaoglu, Y., Kayrin, L., Kaya, B., Effect of allopurinol on lipid peroxidation induced in corporeal tissue by veno-occlusive priapism in a rat model (1997) British Journal of Urology, 80 (3), pp. 476-479. , 2-s2.0-0031399037 | |
dc.description | Evliyaoglu, Y., Kayrin, L., Kaya, B., Effect of pentoxifylline on veno-occlusive priapism-induced corporeal tissule lipid peroxidation in a rat model (1997) Urological Research, 25 (2), pp. 143-147. , DOI 10.1007/BF01037931 | |
dc.description | Sanli, O., Armagan, A., Kandirali, E., Ozerman, B., Ahmedov, I., Solakoglu, S., Nurten, A., Kadioglu, A., TGF-β1 neutralizing antibodies decrease the fibrotic effects of ischemic priapism (2004) International Journal of Impotence Research, 16 (6), pp. 492-497. , DOI 10.1038/sj.ijir.3901261 | |
dc.description | Jin, Y.C., Gam, S.C., Jung, J.H., Hyun, J.S., Chang, K.C., Hyun, J.S., Expression and activity of heme oxygenase-1 in artificially induced low-flow priapism in rat penile tissues (2008) Journal of Sexual Medicine, 5 (8), pp. 1876-1882. , 2-s2.0-48949084667 10.1111/j.1743-6109.2008.00886.x | |
dc.description | Uluocak, N., Atilgan, D., Erdemir, F., Parlaktas, B.S., Yasar, A., Erkorkmaz, U., Akbas, A., An animal model of ischemic priapism and the effects of melatonin on antioxidant enzymes and oxidative injury parameters in rat penis (2010) International Urology and Nephrology, 42 (4), pp. 889-895. , 2-s2.0-78751647310 10.1007/s11255-010-9706-y | |
dc.description | Huang, P.L., Dawson, T.M., Bredt, D.S., Snyder, S.H., Fishman, M.C., Targeted disruption of the neuronal nitric oxide synthase gene (1993) Cell, 75 (7), pp. 1273-1286. , DOI 10.1016/0092-8674(93)90615-W | |
dc.description | Huang, P.L., Huang, Z., Mashimo, H., Bloch, K.D., Moskowitz, M.A., Bevan, J.A., Fishman, M.C., Hypertension in mice lacking the gene for endothelial nitric oxide synthase (1995) Nature, 377 (6546), pp. 239-242. , 2-s2.0-0029021148 | |
dc.description | Paszty, C., Brion, C.M., Manci, E., Witkowska, H.E., Stevens, M.E., Mohandas, N., Rubin, E.M., Transgenic knockout mice with exclusively human sickle hemoglobin and sickle cell disease (1997) Science, 278 (5339), pp. 876-878. , DOI 10.1126/science.278.5339.876 | |
dc.description | Huang, P.L., Lessons learned from nitric oxide synthase knockout animals (2000) Seminars in Perinatology, 24 (1), pp. 87-90 | |
dc.description | Barouch, L.A., Harrison, R.W., Skaf, M.W., Rosas, G.O., Cappola, T.P., Kobeissi, Z.A., Hobai, I.A., Hare, J.M., Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms (2002) Nature, 416 (6878), pp. 337-340. , DOI 10.1038/416005a | |
dc.description | Champion, H.C., Bivalacqua, T.J., Takimoto, E., Kass, D.A., Burnett, A.L., Phosphodiesterase-5A dysregulation in penile erectile tissue is a mechanism of priapism (2005) Proceedings of the National Academy of Sciences of the United States of America, 102 (5), pp. 1661-1666. , DOI 10.1073/pnas.0407183102 | |
dc.description | Hsu, L.L., Champion, H.C., Campbell-Lee, S.A., Bivalacqua, T.J., Manci, E.A., Diwan, B.A., Schimel, D.M., Gladwin, M.T., Hemolysis in sickle cell mice causes pulmonary hypertension due to global impairment in nitric oxide bioavailability (2007) Blood, 109 (7), pp. 3088-3098. , http://bloodjournal.hematologylibrary.org/cgi/reprint/109/7/3088, DOI 10.1182/blood-2006-08-039438 | |
dc.description | Yuan, J.H., Chunn, J.L., Mi, T.J., Adenosine deaminase knockout in mice induces priapism via A2b receptor (2007) Journal of Urology, 177, p. 227 | |
dc.description | Mi, T., Abbasi, S., Zhang, H., Uray, K., Chunn, J.L., Ling, W.X., Molina, J.G., Xia, Y., Excess adenosine in murine penile erectile tissues contributes to priapism via A2B adenosine receptor signaling (2008) Journal of Clinical Investigation, 118 (4), pp. 1491-1501. , http://www.jci.org/articles/view/33467/pdf, DOI 10.1172/JCI33467 | |
dc.description | Bivalacqua, T.J., Musicki, B., Hsu, L.L., Gladwin, M.T., Burnett, A.L., Champion, H.C., Establishment of a transgenic sickle-cell mouse model to study the pathophysiology of priapism (2009) Journal of Sexual Medicine, 6 (9), pp. 2494-2504. , 2-s2.0-69949085119 10.1111/j.1743-6109.2009.01359.x | |
dc.description | Claudino, M.A., Franco-Penteado, C.F., Corat, M.A.F., Gimenes, A.P., Passos, L.A.C., Antunes, E., Costa, F.F., Increased cavernosal relaxations in sickle cell mice priapism are associated with alterations in the NO-cGMP signaling pathway (2009) Journal of Sexual Medicine, 6 (8), pp. 2187-2196. , 2-s2.0-68349157570 10.1111/j.1743-6109.2009.01337.x | |
dc.description | Bivalacqua, T.J., Ross, A.E., Strong, T.D., Gebska, M.A., Musicki, B., Champion, H.C., Burnett, A.L., Attenuated rhoA/rho-kinase signaling in penis of transgenic sickle cell mice (2010) Urology, 76 (2), pp. 510e7-510e12. , 2-s2.0-77955709435 10.1016/j.urology.2010.02.050 | |
dc.description | Wen, J., Jiang, X., Dai, Y., Zhang, Y., Tang, Y., Sun, H., Mi, T., Xia, Y., Adenosine deaminase enzyme therapy prevents and reverses the heightened cavernosal relaxation in priapism (2010) Journal of Sexual Medicine, 7 (9), pp. 3011-3022. , 2-s2.0-77956277664 10.1111/j.1743-6109.2009.01552.x | |
dc.description | Wen, J., Jiang, X., Dai, Y., Zhang, Y., Tang, Y., Sun, H., Mi, T., Xia, Y., Increased adenosine contributes to penile fibrosis, a dangerous feature of priapism, via A2B adenosine receptor signaling (2010) The FASEB Journal, 24 (3), pp. 740-749. , 2-s2.0-77952300616 10.1096/fj.09-144147 | |
dc.description | Tong, Y., Tar, M., Davelman, F., Christ, G., Melman, A., Davies, K.P., Variable coding sequence protein A1 as a marker for erectile dysfunction (2006) BJU International, 98 (2), pp. 396-401. , 2-s2.0-33745726513 10.1111/j.1464-410X.2006.06247.x | |
dc.description | Tong, Y., Tar, M., Monrose, V., DiSanto, M., Melman, A., Davies, K.P., HSMR3A as a Marker for Patients With Erectile Dysfunction (2007) Journal of Urology, 178 (1), pp. 338-343. , DOI 10.1016/j.juro.2007.03.004, PII S0022534707005125 | |
dc.description | Tong, Y., Tar, M., Melman, A., Davies, K., The opiorphin gene (ProL1) and its homologues function in erectile physiology (2008) BJU International, 102 (6), pp. 736-740. , 2-s2.0-50049133667 10.1111/j.1464-410X.2008.07631.x | |
dc.description | Kanika, N.D., Tar, M., Tong, Y., Kuppam, D.S.R., Melman, A., Davies, K.P., The mechanism of opiorphin-induced experimental priapism in rats involves activation of the polyamine synthetic pathway (2009) American Journal of Physiology, 297 (4), pp. C916-C927. , 2-s2.0-70349904712 10.1152/ajpcell.00656.2008 | |
dc.description | Andersson, K.E., Pharmacology of penile erection (2001) Pharmacological Reviews, 53 (3), pp. 417-450. , 2-s2.0-0034849563 | |
dc.description | Phatarpekar, P.V., Wen, J., Xia, Y., Role of adenosine signaling in penile erection and erectile disorders (2010) Journal of Sexual Medicine, 7 (11), pp. 3553-3564. , 2-s2.0-78049461249 10.1111/j.1743-6109.2009.01555.x | |
dc.description | Davidoff, M.S., Middendorff, R., Mayer, B., DeVente, J., Koesling, D., Holstein, A.F., Nitric oxide/cGMP pathway components in the Leydig cells of the human testis (1997) Cell and Tissue Research, 287 (1), pp. 161-170. , DOI 10.1007/s004410050742 | |
dc.description | Andric, S.A., Janjic, M.M., Stojkov, N.J., Kostic, T.S., Protein kinase G-mediated stimulation of basal Leydig cell steroidogenesis (2007) American Journal of Physiology - Endocrinology and Metabolism, 293 (5), pp. E1399-E1408. , http://ajpendo.physiology.org/cgi/reprint/293/5/E1399, DOI 10.1152/ajpendo.00482.2007 | |
dc.description | Burnett, A.L., Lowenstein, C.J., Bredt, D.S., Chang, T.S.K., Snyder, S.H., Nitric oxide: A physiologic mediator of penile erection (1992) Science, 257 (5068), pp. 401-403. , 2-s2.0-0026649942 | |
dc.description | Andersson, K.E., Wagner, G., Physiology of penile erection (1995) Physiological Reviews, 75 (1), pp. 191-236. , 2-s2.0-0028837352 | |
dc.description | Lue, T.F., Erectile dysfunction (2000) New England Journal of Medicine, 342 (24), pp. 1802-1813. , DOI 10.1056/NEJM200006153422407 | |
dc.description | Lucas, K.A., Pitari, G.M., Kazerounian, S., Ruiz-Stewart, I., Park, J., Schulz, S., Chepenik, K.P., Waldman, S.A., Guanylyl cyclases and signaling by cyclic GMP (2000) Pharmacological Reviews, 52 (3), pp. 375-414. , 2-s2.0-0033832073 | |
dc.description | Boolell, M., Allen, M.J., Ballard, S.A., Gepi-Attee, S., Muirhead, G.J., Naylor, A.M., Osterloh, I.H., Gingell, C., Sildenafil: An orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction (1996) International Journal of Impotence Research, 8 (2), pp. 47-52. , 2-s2.0-0030154874 | |
dc.description | Gopal, V.K., Francis, S.H., Corbin, J.D., Allosteric sites of phosphodiesterase-5 (PDE5). A potential role in negative feedback regulation of cGMP signaling in corpus cavernosum (2001) European Journal of Biochemistry, 268 (11), pp. 3304-3312. , DOI 10.1046/j.1432-1327.2001.02233.x | |
dc.description | Ohene-Frempong, K., Steinberg, M.H., Steinberg, M.H., Forget, B.G., Higgs, D.R., Nagel, R.L., Clinical aspects of sickle cell anemia in adults and children (2001) Disorders of Hemoglobin: Genetics, Pathophysiology and Clinical Management, pp. 611-670. , Cambridge, UK Cambridge University Press | |
dc.description | Rogers, Z.R., Priapism in sickle cell disease (2005) Hematology/Oncology Clinics of North America, 19 (5), pp. 917-928. , DOI 10.1016/j.hoc.2005.08.003, PII S0889858805000936, Sickle Cell Disease | |
dc.description | Fredholm, B.B., Ijzerman, A.P., Jacobson, K.A., Klotz, K.-N., Linden, J., International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors (2001) Pharmacological Reviews, 53 (4), pp. 527-552 | |
dc.description | Phatarpekar, P.V., Wen, J., Xia, Y., Role of adenosine signaling in penile erection and erectile disorders (2010) Journal of Sexual Medicine, 7 (11), pp. 3553-3564. , 2-s2.0-78049461249 10.1111/j.1743-6109.2009.01555.x | |
dc.description | Colgan, S.P., Eltzschig, H.K., Eckle, T., Thompson, L.F., Physiological roles for ecto-5′-nucleotidase (CD73) (2006) Purinergic Signalling, 2 (2), pp. 351-360. , 2-s2.0-33947225356 10.1007/s11302-005-5302-5 | |
dc.description | Tostes, R.C., Giachini, F.R.C., Carneiro, F.S., Leite, R., Inscho, E.W., Webb, R.C., Determination of adenosine effects and adenosine receptors in murine corpus cavernosum (2007) Journal of Pharmacology and Experimental Therapeutics, 322 (2), pp. 678-685. , http://jpet.aspetjournals.org/cgi/reprint/322/2/678, DOI 10.1124/jpet.107.122705 | |
dc.description | Olsson, R.A., Pearson, J.D., Cardiovascular purinoceptors (1990) Physiological Reviews, 70 (3), pp. 761-845 | |
dc.description | Tager, A.M., Lacamera, P., Shea, B.S., Campanella, G.S., Selman, M., Zhao, Z., Polosukhin, V., Luster, A.D., The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak (2008) Nature Medicine, 14 (1), pp. 45-54. , 2-s2.0-38049091636 10.1038/nm1685 | |
dc.description | Lin, C.-S., Lin, G., Lue, T.F., Cyclic nucleotide signaling in cavernous smooth muscle (2005) Journal of Sexual Medicine, 2 (4), pp. 478-491. , DOI 10.1111/j.1743-6109.2005.00080.x | |
dc.description | Prieto, D., Physiological regulation of penile arteries and veins (2008) International Journal of Impotence Research, 20 (1), pp. 17-29. , 2-s2.0-38149051425 10.1038/sj.ijir.3901581 | |
dc.description | Vials, A., Burnstock, G., A2-purinoceptor-mediated relaxation in the guinea-pig coronary vasculature: A role for nitric oxide (1993) British Journal of Pharmacology, 109 (2), pp. 424-429 | |
dc.description | Sobrevia, L., Yudilevich, D.L., Mann, G.E., Activation of A2-purinoceptors by adenosine stimulates L-arginine transport (system y+) and nitric oxide synthesis in human fetal endothelial cells (1997) Journal of Physiology, 499 (1), pp. 135-140 | |
dc.description | Li, J.-M., Fenton, R.A., Wheeler, H.B., Powell, C.C., Peyton, B.D., Cutler, B.S., Dobson Jr., J.G., Adenosine A(2a) receptors increase arterial endothelial cell nritric oxide (1998) Journal of Surgical Research, 80 (2), pp. 357-364. , DOI 10.1006/jsre.1998.5439 | |
dc.description | Chiang, P.H., Wu, S.N., Tsai, E.M., Wu, C.C., Shen, M.R., Huang, C.H., Chiang, C.P., Adenosine modulation of neurotransmission in penile erection (1994) British Journal of Clinical Pharmacology, 38 (4), pp. 357-362 | |
dc.description | Faria, M., Magalhaes-Cardoso, T., Lafuente-De-Carvalho, J.-M., Correia-De-Sa, P., Corpus cavernosum from men with vasculogenic impotence is partially resistant to adenosine relaxation due to endothelial A2B receptor dysfunction (2006) Journal of Pharmacology and Experimental Therapeutics, 319 (1), pp. 405-413. , http://jpet.aspetjournals.org/cgi/reprint/319/1/405, DOI 10.1124/jpet.106.107821 | |
dc.description | Dai, Y., Zhang, Y., Phatarpekar, P., Mi, T., Zhang, H., Blackburn, M.R., Xia, Y., Adenosine signaling, priapism and novel therapies (2009) Journal of Sexual Medicine, 6 (3 SUPPL.), pp. 292-301. , 2-s2.0-61849106424 10.1111/j.1743-6109.2008.01187.x | |
dc.description | Wen, J., Jiang, X., Dai, Y., Zhang, Y., Tang, Y., Sun, H., Mi, T., Xia, Y., Increased adenosine contributes to penile fibrosis, a dangerous feature of priapism, via A2B adenosine receptor signaling (2010) The FASEB Journal, 24 (3), pp. 740-749. , 2-s2.0-77952300616 10.1096/fj.09-144147 | |
dc.description | Chitaley, K., Wingard, C.J., Clinton Webb, R., Branam, H., Stopper, V.S., Lewis, R.W., Mills, T.M., Antagonism of Rho-kinase stimulates rat penile erection via a nitric oxide-independent pathway (2001) Nature Medicine, 7 (1), pp. 119-122. , DOI 10.1038/83258 | |
dc.description | Mills, T.M., Chitaley, K., Wingard, C.J., Lewis, R.W., Webb, R.C., Effect of rho-kinase inhibition on vasoconstriction in the penile circulation (2001) Journal of Applied Physiology, 91 (3), pp. 1269-1273 | |
dc.description | Bivalacqua, T.J., Champion, H.C., Usta, M.F., Cellek, S., Chitaley, K., Webb, R.C., Lewis, R.L., Kadowitz, P.J., RhoA/Rho-kinase suppresses endothelial nitric oxide synthase in the penis: A mechanism for diabetes-associated erectile dysfunction (2004) Proceedings of the National Academy of Sciences of the United States of America, 101 (24), pp. 9121-9126. , DOI 10.1073/pnas.0400520101 | |
dc.description | Musicki, B., Ross, A.E., Champion, H.C., Burnett, A.L., Bivalacqua, T.J., Posttranslational modification of constitutive nitric oxide synthase in the penis (2009) Journal of Andrology, 30 (4), pp. 352-362. , 2-s2.0-68549118890 10.2164/jandrol.108.006999 | |
dc.description | Somlyo, A.P., Somlyo, A.V., Ca2+ sensitivity of smooth muscle and nonmuscle myosin II: Modulated by G proteins, kinases, and myosin phosphatase (2003) Physiological Reviews, 83 (4), pp. 1325-1358 | |
dc.description | Wettschureck, N., Offermanns, S., Rho/Rho-kinase mediated signaling in physiology and pathophysiology (2002) Journal of Molecular Medicine, 80 (10), pp. 629-638. , DOI 10.1007/s00109-002-0370-2 | |
dc.description | Riento, K., Ridley, A.J., Rocks: Multifunctional kinases in cell behaviour (2003) Nature Reviews Molecular Cell Biology, 4 (6), pp. 446-456. , DOI 10.1038/nrm1128 | |
dc.description | Bhattacharya, M., Babwah, A.V., Ferguson, S.S.G., Small GTP-binding protein-coupled receptors (2004) Biochemical Society Transactions, 32 (6), pp. 1040-1044. , DOI 10.1042/BST0321040 | |
dc.description | Hart, M.J., Sharma, S., Elmasry, N., Qiu, R.-G., McCabe, P., Polakis, P., Bollag, G., Identification of a novel guanine nucleotide exchange factor for the Rho GTPase (1996) Journal of Biological Chemistry, 271 (41), pp. 25452-25458. , DOI 10.1074/jbc.271.41.25452 | |
dc.description | Fukuhara, S., Murga, C., Zohar, M., Igishi, T., Gutkind, J.S., A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho (1999) Journal of Biological Chemistry, 274 (9), pp. 5868-5879. , DOI 10.1074/jbc.274.9.5868 | |
dc.description | Kourlas, P.J., Strout, M.P., Becknell, B., Veronese, M.L., Croce, C.M., Theil, K.S., Krahe, R., Caligiuri, M.A., Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: Evidence for its fusion with MLL in acute myeloid leukemia (2000) Proceedings of the National Academy of Sciences of the United States of America, 97 (5), pp. 2145-2150. , DOI 10.1073/pnas.040569197 | |
dc.description | Ross, E.M., Wilkie, T.M., GTPase-activating proteins for heterotrimeric G proteins: Regulators of G Protein Signaling (RGS) and RGS-like proteins (2000) Annual Review of Biochemistry, 69, pp. 795-827. , 2-s2.0-0033783132 10.1146/annurev.biochem.69.1.795 | |
dc.description | Fukuharaa, S., Chikumi, H., Silvio Gutkind, J., RGS-containing RhoGEFs: The missing link between transforming G proteins and Rho? (2001) Oncogene, 20 (13), pp. 1661-1668. , DOI 10.1038/sj.onc.1204182, REV. ISS. 1 | |
dc.description | Schmidt, A., Hall, A., Guanine nucleotide exchange factors for Rho GTPases: Turning on the switch (2002) Genes and Development, 16 (13), pp. 1587-1609. , DOI 10.1101/gad.1003302 | |
dc.description | Teixeira, C.E., Priviero, F.B.M., Webb, R.C., Effects of 5-cyclopropyl-2-[1-(2-fluoro-benzyl)-1H-pyrazolo[3,4-b] pyridine- 3-yl]pyrimidin-4-ylamine (BAY 41-2272) on smooth muscle tone, soluble guanylyl cyclase activity, and NADPH oxidase activity/expression in corpus cavernosum from wild-type, neuronal, and endothelial nitric-oxide synthase null mice (2007) Journal of Pharmacology and Experimental Therapeutics, 322 (3), pp. 1093-1102. , http://jpet.aspetjournals.org/cgi/reprint/322/3/1093, DOI 10.1124/jpet.107.124594 | |
dc.description | Somlyo, A.V., New roads leading to Ca2+ sensitization (2002) Circulation Research, 91 (2), pp. 83-84. , DOI 10.1161/01.RES.0000028341.63905.91 | |
dc.description | Mantadakis, E., Ewalt, D.H., Cavender, J.D., Rogers, Z.R., Buchanan, G.R., Outpatient penile aspiration and epinephrine irrigation for young patients with sickle cell anemia and prolonged priapism (2000) Blood, 95 (1), pp. 78-82 | |
dc.description | Kato, G.J., Priapism in sickle-cell disease: A hematologist's perspective (2012) The Journal of Sexual Medicine, 9 (1), pp. 70-78 | |
dc.description | Bialecki, E.S., Bridges, K.R., Sildenafil relieves priapism in patients with sickle cell disease [1] (2002) American Journal of Medicine, 113 (3), p. 252 | |
dc.description | Serjeant, G.R., De Ceulaer, K., Maude, G.H., Stilboestrol and stuttering priapism in homozygous sickle-cell disease (1985) Lancet, 2 (8467), pp. 1274-1276 | |
dc.description | Levine, L.A., Guss, S.P., Gerber, G., Gonadotropin-releasing hormone analogues in the treatment of sickle cell anemia-associated priapism (1993) Journal of Urology, 150 (2), pp. 475-477 | |
dc.description | Rachid-Filho, D., Cavalcanti, A.G., Favorito, L.A., Costa, W.S., Sampaio, F.J.B., Treatment of recurrent priapism in sickle cell anemia with finasteride: A new approach (2009) Urology, 74 (5), pp. 1054-1057. , 2-s2.0-70350574017 10.1016/j.urology.2009.04.071 | |
dc.description | Okpala, I., Westerdale, N., Jegede, T., Cheung, B., Etilefrine for the prevention of priapism in adult sickle cell disease (2002) British Journal of Haematology, 118 (3), pp. 918-921. , DOI 10.1046/j.1365-2141.2002.03691.x | |
dc.description | Seftel, A.D., A prospective diary study of stuttering priapism in adolescents and young men with sickle cell anemia: Report of an international randomized control trial | |
dc.description | The priapism in sickle cell study (PISCES study) (2011) Journal of Urology, 185 (5), pp. 1837-1838. , 2-s2.0-79953799587 10.1016/j.juro.2011.01.068 | |
dc.description | Saad, S.T.O., Lajolo, C., Gilli, S., Marques Jr., J.F.C., Lima, C.S., Costa, F.F., Arruda, V.R., Follow-up of sickle cell disease patients with priapism treated by hydroxyurea (2004) American Journal of Hematology, 77 (1), pp. 45-49. , DOI 10.1002/ajh.20142 | |
dc.description | Hassan, A., Jam'a, A., Al Dabbous, I.A., Hydroxyurea in the treatment of sickle cell associated priapism (1998) Journal of Urology, 159 (5), p. 1642 | |
dc.description | MacHado, R.F., Barst, R.J., Yovetich, N.A., Hassell, K.L., Kato, G.J., Gordeuk, V.R., Gibbs, J.S.R., Gladwin, M.T., Hospitalization for pain in patients with sickle cell disease treated with sildenafil for elevated TRV and low exercise capacity (2011) Blood, 118 (4), pp. 855-864. , 2-s2.0-79961004549 10.1182/blood-2010-09-306167 | |
dc.description | Charache, S., Terrin, M.L., Moore, R.D., Dover, G.J., Barton, F.B., Eckert, S.V., McMahon, R.P., Bonds, D.R., Effect of hydroxyurea on the frequency of painful crises in Sickle cell anemia (1995) The New England Journal of Medicine, 332 (20), pp. 1317-1322. , 2-s2.0-0029025475 10.1056/NEJM199505183322001 | |
dc.description | Bakanay, S.M., Dainer, E., Clair, B., Adekile, A., Daitch, L., Wells, L., Holley, L., Kutlar, A., Mortality in sickle cell patients on hydroxyurea therapy (2005) Blood, 105 (2), pp. 545-547. , DOI 10.1182/blood-2004-01-0322 | |
dc.description | Platt, O.S., Brambilla, D.J., Rosse, W.F., Milner, P.F., Castro, O., Steinberg, M.H., Klug, P.P., Mortality in sickle cell disease - Life expectancy and risk factors for early death (1994) New England Journal of Medicine, 330 (23), pp. 1639-1644. , DOI 10.1056/NEJM199406093302303 | |
dc.description | Powars, D.R., Chan, L.S., Hiti, A., Ramicone, E., Johnson, C., Outcome of sickle cell anemia: A 4-decade observational study of 1056 patients (2005) Medicine, 84 (6), pp. 363-376. , DOI 10.1097/01.md.0000189089.45003.52 | |
dc.description | Fitzhugh, C.D., Lauder, N., Jonassaint, J.C., Telen, M.J., Zhao, X., Wright, E.C., Gilliam, F.R., De Castro, L.M., Cardiopulmonary complications leading to premature deaths in adult patients with sickle cell disease (2010) American Journal of Hematology, 85 (1), pp. 36-40. , 2-s2.0-74049151134 10.1002/ajh.21569 | |
dc.description | Nahoum, C.R.D., Almeida Fontes, E., Freire, F.R., Semen analysis in sickle cell disease (1980) Andrologia, 12 (6), pp. 542-545 | |
dc.description | Osegbe, D.N., Akinyanju, O., Amaku, E.O., Fertility in males with sickle cell disease (1981) Lancet, 2 (8241), pp. 275-276 | |
dc.description | Agbaraji, V.O., Scott, R.B., Leto, S., Kingslow, L.W., Fertility studies in sickle cell disease: Semen analysis in adult male patients (1988) International Journal of Fertility, 33 (5), pp. 347-352 | |
dc.description | Berthaut, I., Guignedoux, G., Kirsch-Noir, F., De Larouziere, V., Ravel, C., Bachir, D., Galacteros, F., Mandelbaum, J., Influence of sickle cell disease and treatment with hydroxyurea on sperm parameters and fertility of human males (2008) Haematologica, 93 (7), pp. 988-993. , http://www.haematologica.org/cgi/reprint/93/7/988, DOI 10.3324/haematol.11515 | |
dc.description | Lu, C.C., Meistrich, M.L., Cytotoxic effects of chemotherapeutic drugs on mouse testis cells (1979) Cancer Research, 39 (9), pp. 3575-3582 | |
dc.description | Ficsor, G., Ginsberg, L.C., The effect of hydroxyurea and mitomycin C on sperm motility in mice (1980) Mutation Research, 70 (3), pp. 383-387 | |
dc.description | Singh, H., Taylor, C., Effects of Thio-TEPA and hydroxyurea on sperm production in Lakeview hamsters (1981) Journal of Toxicology and Environmental Health, 8 (1-2), pp. 307-316 | |
dc.description | Evenson, D.P., Jost, L.K., Hydroxyurea exposure alters mouse testicular kinetics and sperm chromatin structure (1993) Cell Proliferation, 26 (2), pp. 147-159 | |
dc.description | Wiger, R., Hongslo, J.K., Evenson, D.P., De Angelis, P., Schwarze, P.E., Holme, J.A., Effects of acetaminophen and hydroxyurea on spermatogenesis and sperm chromatin structure in laboratory mice (1995) Reproductive Toxicology, 9 (1), pp. 21-33. , 2-s2.0-0029105299 10.1016/0890-6238(94)00052-X | |
dc.description | Saez, J.M., Leydig cells: Endocrine, paracrine, and autocrine regulation (1994) Endocrine Reviews, 15 (5), pp. 574-626. , DOI 10.1210/er.15.5.574 | |
dc.description | Jones, K.M., Niaz, M.S., Brooks, C.M., Roberson, S.I., Aguinaga, M.P., Hills, E.R., Rice, V.M., Archibong, A.E., Adverse effects of a clinically relevant dose of hydroxyurea used for the treatment of sickle cell disease on male fertility endpoints (2009) International Journal of Environmental Research and Public Health, 6 (3), pp. 1124-1144. , 2-s2.0-67649233786 10.3390/ijerph6031124 | |
dc.description | Friedman, G., Freeman, R., Bookchin, R., Testicular function in sickel cell disease (1974) Fertility and Sterility, 25 (12), pp. 1018-1021. , 2-s2.0-0016164202 | |
dc.description | Abbasi, A.A., Prasad, A.S., Ortega, J., Gonadal function abnormalities in sickle cell anemia | |
dc.description | Studies in male adult patients (1976) Annals of Internal Medicine, 85 (5), pp. 601-605. , 2-s2.0-0017110215 | |
dc.description | Modebe, O., Ezeh, U.O., Effect of age on testicular function in adult males with sickle cell anemia (1995) Fertility and Sterility, 63 (4), pp. 907-912. , 2-s2.0-0028952193 | |
dc.description | Dada, O.A., Nduka, E.U., Endocrine function and hemoglobinopathies: Relation between the sickle cell gene and circulating plasma levels of testosterone, luteinizing hormone (LH) and follicle stimulating hormone (FSH) in adult males (1980) Clinica Chimica Acta, 105 (2), pp. 269-273. , DOI 10.1016/0009-8981(80)90469-6 | |
dc.description | El-Hazmi, M.A.F., Bahakim, H.M., Al-Fawaz, I., Endocrine functions in sickle cell anaemia patients (1992) Journal of Tropical Pediatrics, 38 (6), pp. 307-313 | |
dc.description | Abudu, E.K., Akanmu, S.A., Soriyan, O.O., Serum testosterone levels of HbSS (sickle cell disease) male subjects in Lagos, Nigeria (2011) BMC Research Notes, 17 (4), p. 298 | |
dc.description | Osegbe, D.N., Akinyanju, O.O., Testicular dysfunction in men with sickle cell disease (1987) Postgraduate Medical Journal, 63 (736), pp. 95-98 | |
dc.description | Abdulwaheed, O.O., Abdulrasaq, A.A., Sulaiman, A.K., The hormonal assessment of the infertile male in Ilorin, Nigeria (2002) African Journal of Clinical Endocrinology & Metabolism, 3, pp. 62-64 | |
dc.description | Gofrit, O.N., Rund, D., Shapiro, A., Pappo, O., Landau, E.H., Pode, D., Segmental testicular infarction due to sickle cell disease (1998) Journal of Urology, 160 (3), pp. 835-836. , DOI 10.1016/S0022-5347(01)62803-9 | |
dc.description | Prasad, A.S., Schoomaker, E.B., Ortega, J., Zinc deficiency in sickle cell disease (1975) Clinical Chemistry, 21 (4), pp. 582-587. , 2-s2.0-0016583799 | |
dc.description | Prasad, A.S., Cossack, Z.T., Zinc supplementation and growth in sickle cell disease (1984) Annals of Internal Medicine, 100 (3), pp. 367-371 | |
dc.description | Landefeld, C.S., Schambelan, M., Kaplan, S.L., Embury, S.H., Clomiphene-responsive hypogonadism in sickle cell anemia (1983) Annals of Internal Medicine, 99 (4), pp. 480-483 | |
dc.description | Jiminez, C.T., Scott, R.B., Henry, W.L., Studies in sickle cell anemia. XXVI. The effect of homozygous sickle cell disease on the onset of menarche, pregnancy, fertility, pubescent changes and body growth in Negro subjects (1966) American Journal of Diseases of Children, 111, pp. 497-503 | |
dc.description | Platt, O.S., Rosenstock, W., Espeland, M.A., Influence of sickle hemoglobinopathies on growth and development (1984) New England Journal of Medicine, 311 (1), pp. 7-12 | |
dc.description | Zago, M.A., Kerbauy, J., Souza, H.M., Figueiredo, M.S., Costa, F.F., Cruz, S.M.P., Braga, J.A.P., Pinto, B.O., Growth and sexual maturation of Brazilian patients with sickle cell diseases (1992) Tropical and Geographical Medicine, 44 (4), pp. 317-321 | |
dc.description | Li, M., Fogarty, J., Whitney, K.D., Stone, P., Repeated testicular infarction in a patient with sickle cell disease: A possible mechanism for testicular failure (2003) Urology, 62 (3), pp. 551xi-551xiv. , DOI 10.1016/S0090-4295(03)00482-5 | |
dc.description | Dufau, M.L., The luteinizing hormone receptor (1998) Annual Review of Physiology, 60, pp. 461-496. , DOI 10.1146/annurev.physiol.60.1.461 | |
dc.description | Ascoli, M., Fanelli, F., Segaloff, D.L., The lutropin/choriogonadotropin receptor, a 2002 perspective (2002) Endocrine Reviews, 23 (2), pp. 141-174. , DOI 10.1210/er.23.2.141 | |
dc.description | Stocco, D.M., StAR protein and the regulation of steroid hormone biosynthesis (2001) Annual Review of Physiology, 63, pp. 193-213. , DOI 10.1146/annurev.physiol.63.1.193 | |
dc.description | Tremblay, J.J., Hamel, F., Viger, R.S., Protein kinase A-dependent cooperation between GATA and CCAAT/enhancer-binding protein transcription factors regulates steroidogenic acute regulatory protein promoter activity (2002) Endocrinology, 143 (10), pp. 3935-3945. , DOI 10.1210/en.2002-220413 | |
dc.description | Epstein, L.F., Orme-Johnson, N.R., Acute action of luteinizing hormone on mouse Leydig cells: Accumulation of mitochondrial phosphoproteins and stimulation of testosterone synthesis (1991) Molecular and Cellular Endocrinology, 81 (1-3), pp. 113-126. , 2-s2.0-0025882945 | |
dc.description | Epstein, L.F., Orme-Johnson, N.R., Regulation of steroid hormone biosynthesis: Identification of precursors of a phosphoprotein targeted to the mitochondrion in stimulated rat adrenal cortex cells (1991) Journal of Biological Chemistry, 266 (29), pp. 19739-19745 | |
dc.description | Seebacher, T., Beitz, E., Kumagami, H., Wild, K., Ruppersberg, J.P., Schultz, J.E., Expression of membrane-bound and cytosolic guanylyl cyclases in the rat inner ear (1999) Hearing Research, 127 (1-2), pp. 95-102. , DOI 10.1016/S0378-5955(98)00176-2, PII S0378595598001762 | |
dc.description | Arakane, F., King, S.R., Du, Y., Kallen, C.B., Walsh, L.P., Watari, H., Stocco, D.M., Strauss III, J.F., Phosphorylation of steroidogenic acute regulatory protein (StAR) modulates its steroidogenic activity (1997) Journal of Biological Chemistry, 272 (51), pp. 32656-32662. , DOI 10.1074/jbc.272.51.32656 | |
dc.description | Artemenko, I.P., Zhao, D., Hales, D.B., Hales, K.H., Jefcoate, C.R., Mitochondrial processing of newly synthesized steroidogenic acute regulatory protein (StAR), but not total StAR, mediates cholesterol transfer to cytochrome P450 side chain cleavage enzyme in adrenal cells (2001) | |
dc.publisher | | |
dc.relation | Anemia | |
dc.rights | aberto | |
dc.source | Scopus | |
dc.title | Sickling Cells, Cyclic Nucleotides, And Protein Kinases: The Pathophysiology Of Urogenital Disorders In Sickle Cell Anemia | |
dc.type | Artículos de revistas | |