Artículos de revistas
Flavonoids Bearing An O-arabinofuranosyl-(1→3)-rhamnoside Moiety From Cladocolea Micrantha: Inhibitory Effect On Human Melanoma Cells
Registro en:
Natural Product Communications. , v. 7, n. 10, p. 1311 - 1314, 2012.
1934578X
2-s2.0-84869855508
Autor
Guimaraes A.C.
Magalhaes A.
Nakamura M.J.
Siani A.C.
Barja-Fidalgo C.
Sampaio A.L.F.
Institución
Resumen
Eleven known triterpenes (α-amyrin, β-amyrin, lupeol, and their respective acetates, 3-O-acetyl derivatives of betulinic, oleanolic, and ursolic acids, cycloartenol, and tirucall-7,24-dienol), two new flavonols presenting an uncommon interglycosidic O-(1→3) linkage (kaempferol 3-O-α-L- arabinofuranosyl- (1→3)-α-L-rhamnoside and quercetin 3-O-α-L-arabinofuranosyl-(1→3)-α-L-rhamnoside), β-sitosterol, stigmasterol, quercetin, and gallic acid were isolated from the Amazonian medicinal mistletoe, Cladocolea micrantha Kuijt (Loranthaceae). Their structures were established by spectral methods and eventual chromatographic comparisons. The quercetin derivative was not cytotoxic to MV3 human melanoma cells, but was able, when administered at 1 μg/mL, to promote a twofold inhibition of the migration of the cells through the transwell system when compared with paclitaxel at 5 μM. 7 10 1311 1314 Gentry, A.H., (1993) A Field Guide to the Families and Genera of Woody Plants of Northwest South America (Colombia, Ecuador, Peru) with Supplementary Notes on Herbaceous Taxa, pp. 564-569. , Conservation International Washington, Washington DC Cáceres, A., (1996) Plantas de Uso Medicinal en Guatemala, pp. 276-279. , Editorial Universitária de Universidade de San Carlos de Guatemala, Guatemala Kuijt, J., Inflorescence structure and generic placement of some small-flowered species of Phthirusa (Loranthaceae) (1991) Systematic Botany, 16, pp. 283-291 Lin, J.-H., Chiou, Y.-N., Lin, Y.-L., Phenolic glycosides from Viscum angulatum (2002) Journal of Natural Products, 65 (5), pp. 638-640. , DOI 10.1021/np010548z Guimarães, A.C., Aspectos etnobotânicos e químicos da família Loranthaceae e Viscaceae: Potencialidades terapêuticas das ervas-depassarinho parasitas (2006) Revista Fitos, 2, pp. 27-47 Harborne, J.B., (1994) The Flavonoids: Advances in Research since 1986, , Chapman and Hall, London, UK Yan, X., Murphy, B.T., Hammond, G.B., Vinson, J.A., Neto, C.C., Antioxidant activities and antitumor screening of extracts from Cranberry fruit (Vaccinium macrocarpon) (2002) Journal of Agricultural and Food Chemistry, 50 (21), pp. 5844-5849. , DOI 10.1021/jf0202234 Vvedenskaya, I.O., Rosen, R.T., Guido, J.E., Russell, D.J., Mills, K.A., Vorsa, N., Characterization of flavonols in cranberry (Vaccinium macrocarpon) powder (2004) Journal of Agricultural and Food Chemistry, 52, pp. 188-195 Vaishnav, M.M., Gupta, K.R., Ombuin 3-O-arabinofuranoside from Coccinia indica (1996) Fitoterapia, 67 (1), p. 80 Ishimaru, K., Omoto, T., Asai, I., Ezaki, K., Shimomura, K., Taxifolin 3-arabinoside from Fragaria x ananassa (1995) Phytochemistry, 40, pp. 345-347 Li, T.-M., Li, W.-K., Yu, J.-G., Flavonoids from Artabotrys hexapetalus (1997) Phytochemistry, 45 (4), pp. 831-833. , DOI 10.1016/S0031-9422(97)00012-5, PII S0031942297000125 Lin, H.-C., Tsai, S.-F., Lee, S.-S., Flavonoid glycosides from the leaves of Machilus philippinensis (2011) Journal of the Chinese Chemical Society, 58, pp. 555-562 Williams, C., Flavone and flavonol O-glycosides (2006) Flavonoids - Chemistry, Biochemistry and Applications, pp. 749-856. , Andersen Ø, Markham M. (Eds). CRC Press, Boca Raton, Fl Harvala, E., Exner, J., Becker, H., Flavonoids of Loranthus europaeus (1984) Journal of Natural Products, 47 (6), pp. 1054-1055. , DOI 10.1021/np50036a034 Orhan, D.D., Küpeli, E., Yesilada, E., Ergun, F., Anti-inflammatory and antinociceptive activity of flavonoids isolated from Viscum album ssp. album (2006) Zeitschrift für Naturforschung, 61, pp. 26-30 Zhao, Y., Yu, Z., Fan, R., Gao, X., Yu, M., Li, H., Wei, H., Bi, K., Simultaneous determination of ten flavonoids from Viscum coloratum grown on different host species and different sources by LC-MS (2011) Chemical & Pharmaceutical Bulletin, 59, pp. 1322-1328 Weng, C.-J., Yen, G.C., Flavonoids, a ubiquitous dietary phenolic subclass, exert extensive in vitro anti-invasive and in vivo anti-metastatic activities (2012) Cancer and Metastasis Reviews, 31, pp. 323-351