Doxycycline Ameliorates The Dystrophic Phenotype Of Skeletal And Cardiac Muscles In Mdx Mice

dc.creatorPereira J.A.
dc.creatorTaniguti A.P.T.
dc.creatorMatsumura C.
dc.creatorMarques M.J.
dc.creatorNeto H.S.
dc.date2012
dc.date2015-06-25T20:25:38Z
dc.date2015-11-26T15:22:02Z
dc.date2015-06-25T20:25:38Z
dc.date2015-11-26T15:22:02Z
dc.date.accessioned2018-03-28T22:31:25Z
dc.date.available2018-03-28T22:31:25Z
dc.identifier
dc.identifierMuscle And Nerve. , v. 46, n. 3, p. 400 - 406, 2012.
dc.identifier0148639X
dc.identifier10.1002/mus.23331
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84865335628&partnerID=40&md5=a153f1e4192c8516090f87746ecedbc8
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/90495
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/90495
dc.identifier2-s2.0-84865335628
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1260341
dc.descriptionIntroduction: We examined whether doxycycline, an antibiotic member of the tetracycline family, improves the histopathology and muscle function in mdx mice, the experimental model of DMD. Methods: Doxycycline was administered for 36 days (starting on postnatal day 0) and for 9 months (starting at 8 months of age) in drinking water. Histopathological, biochemical (creatine kinase), and functional (forelimb muscle grip strength) parameters were evaluated in limb, diaphragm, and cardiac muscle. Results: Doxycycline significantly minimized the dystrophic phenotype of skeletal and cardiac muscles and improved forelimb muscle strength. The drug protected muscle fibers against myonecrosis and reduced inflammation. Furthermore, it slowed the progression of myocardial fibrosis. Conclusions: This study provides evidence that doxycycline may be a potential therapeutic agent for DMD. © 2012 Wiley Periodicals, Inc.
dc.description46
dc.description3
dc.description400
dc.description406
dc.descriptionHoffman, E.P., Brown Jr., R.H., Kunkel, L.M., Dystrophin: the protein product of the Duchenne muscular dystrophy locus (1987) Cell, 51, pp. 919-928
dc.descriptionEngel, A.G., Yamamoto, M., Fischbeck, K.H., Muscular dystrophies (1994) Myology, pp. 1133-1187. , Engel AG, Franzini-Armstrong C, editors. New York: McGraw-Hill
dc.descriptionFrankel, K.A., Rosser, R.J., The pathology of the heart in progressive muscular dystrophy: epimyocardial fibrosis (1976) Hum Pathol, 7, pp. 375-386
dc.descriptionConnuck, D.M., Sleeper, L.A., Colan, S.D., Cox, G.F., Towbin, J.A., Lowe, A.M., Characteristics and outcomes of cardiomyopathy in children with Duchenne or Becker muscular dystrophy: a comparative study from the Pediatric Cardiomyophaty Registry (2008) Am Heart J, 155, pp. 998-1005
dc.descriptionShah, A.M., Jefferies, J.L., Rossano, J.W., Decker, J.A., Cannon, B.C., Kim, J.J., Electrocardiographic abnormalities and arrhythmias are strongly associated with the development of cardiomyopathy in muscular dystrophy (2010) Heart Rhythm, 7, pp. 1484-1488
dc.descriptionKhurana, T.S., Davies, K.E., Pharmacological strategies for muscular dystrophy (2003) Nat Rev Drug Discov, 2, pp. 379-390
dc.descriptionGrounds, M.D., Torrisi, J., Anti-TNFalpha (Remicade) therapy protects dystrophic skeletal muscle from necrosis (2004) FASEB J, 18, pp. 676-682
dc.descriptionTidball, J.G., Wehling-Henricks, M., Evolving therapeutics strategies for Duchenne muscular dystrophy: targeting downstream events (2004) Pediatr Res, 56, pp. 831-841
dc.descriptionGirgenrath, M., Beermann, M.L., Vishnudas, V.K., Homma, S., Miller, J.B., Pathology is alleviated by doxycycline in an laminin-alpha2-null model of congenital muscular dystrophy (2009) Ann Neurol, 65, pp. 47-56
dc.descriptionGriffin, M.O., Fricovsky, E., Ceballos, G., Villarreal, F., Tetracyclines: a pleitropic family of compounds with promising therapeutic properties. Review of the literature (2010) Am J Physiol Cell Physiol, 299, pp. C539-C548
dc.descriptionDavies, J.E., Wang, L., Garcia-Oroz, L., Cook, L.J., Vacher, C., O'Donovan, D.G., Doxycycline attenuates and delays toxicity of the oculopharyngeal muscular dystrophy mutation in transgenic mice (2005) Nat Med, 11, pp. 672-677
dc.descriptionTaniguti, A.P., Pertille, A., Matsumura, C.Y., Santo Neto, H., Marques, M.J., Prevention of muscle fibrosis and myonecrosis in mdx by suramin, a TGF-b1 blocker (2010) Muscle Nerve, 43, pp. 82-87
dc.descriptionMatsumura, C.Y., Pertille, A., Albuquerque, T.C.P., Santo Neto, H., Marques, M.J., Diltiazem and verapamil protect dystrophin-deficient muscle fibers of mdx mice from degeneration: a potential role in calcium buffering and sarcolemmal stability (2009) Muscle Nerve, 39, pp. 167-176
dc.descriptionLefaucheur, J.P., Pastoret, C., Sebille, A., Phenotype of dystrophinopathy in old mdx mice (1995) Anat Rec, 242, pp. 70-76
dc.descriptionPorter, J.D., Merrian, A.P., Leahy, P., Gong, B., Khanna, S., Dissection of temporal gene expression signatures of affected and spared muscle groups in dystrophin-deficient (mdx) mice (2003) Hum Mol Genet, 12, pp. 1813-1821
dc.descriptionGorospe, J.R., Tharp, M.D., Hinckley, J., Kornegay, J.N., Hoffman, E.P., A role for mast cells in the progression of Duchenne muscular dystrophy? Correlations in dystrophin-deficient humans, dogs and mice (1994) J Neurol Sci, 122, pp. 44-56
dc.descriptionGussoni, E., Pavlath, G.K., Miller, R.G., Panzara, M.A., Powell, M., Blau, H.M., Steinman, L., Specific T cell receptor gene rearrangements at the site of muscle degeneration in Duchenne muscular dystrophy (1994) J Immunol, 153, pp. 4798-4805
dc.descriptionSánchez, A.R., Rogers, R.S., Sheridan, P.J., Tetracycline and other tetracycline-derivative staining of the teeth and oral cavity (2004) Int J Dermatol, 43, pp. 709-715
dc.descriptionTurner, P.R., Fong, P., Denetclaw, W.F., Steinhardt, R.A., Increased calcium influx in dystrophic muscle (1991) J Cell Biol, 115, pp. 1701-1712
dc.descriptionRobert, V., Massimino, M.L., Tosello, V., Marsault, R., Cantini, M., Sorrentino, V., Alterations in calcium handling at the subcellular level in mdx myotubes (2001) J Biol Chem, 276, pp. 4647-4651
dc.descriptionAbmayr, S., Crawford, R.W., Chamberlain, J.S., Characterization of ARC, apoptosis repressor interacting with CARD, in normal and dystrophin-deficient skeletal muscle (2004) Hum Mol Genet, 13, pp. 213-221
dc.descriptionTidball, J.G., Albrecht, D.E., Lokensgard, B.E., Spencer, M.J., Apoptosis precedes necrosis of dystrophin-deficient muscle (1995) J Cell Sci, 108, pp. 2197-2204
dc.descriptionCoulton, G.R., Curtin, N.A., Morgan, J.E., Partridge, T.A., The mdx mouse skeletal muscle myopathy: II. Contractile properties (1988) Neuropathol Appl Neurobiol, 14, pp. 299-314
dc.descriptionMuntoni, F., Mateddu, A., Marchei, F., Clerk, A., Serra, G., Muscular weakness in the mdx mouse (1993) J Neurol Sci, 120, pp. 71-77
dc.descriptionDe Luca, A., Pierno, S., Liantonio, A., Cetrone, M., Camerino, C., Fraysse, B., Enhanced dystrophic progression in mdx mice by exercise and beneficial effects of taurine and insulin-like growth factor-1 (2003) J Pharmacol Exp Ther, 304, pp. 453-463
dc.descriptionStedman, H.H., Sweeney, H.L., Shrager, J.B., Maguire, H.C., Panettieri, R.A., Petrof, B., The mdx mouse diaphragm reproduces the degenerative changes of Duchenne muscular dystrophy (1991) Nature, 352, pp. 536-539
dc.descriptionEagle, M., Baudouin, S.V., Chandler, C., Giddings, D.R., Bullock, R., Bushby, K., Survival in Duchenne muscular dystrophy: improvements in life expectancy since 1967 and the impact of home nocturnal ventilation (2002) Neuromuscul Disord, 12, pp. 926-929
dc.descriptionTownsend, D., Yasuda, S., Li, S., Chamberlain, J.S., Metzger, J.M., Emergent dilated cardiomyopathy caused by targeted repair of dystrophic skeletal muscle (2008) Mol Ther, 16, pp. 832-835
dc.descriptionVitiello, L., Bassi, N., Campagnolo, P., Zaccariotto, E., Occhi, G., Malerba, A., In vivo delivery of naked antisense oligos in aged mdx mice: analysis of dystrophin restoration in skeletal and cardiac muscle (2008) Neuromuscul Disord, 18, pp. 597-605
dc.descriptionTownsend, D., Yasuda, S., Chamberlain, J., Metzger, M., Cardiac consequences to skeletal muscle-centric therapeutics for Duchenne muscular dystrophy (2009) Trends Cardiovasc Med, 19, pp. 50-55
dc.descriptionFayssoil, A., Nardi, O., Orlikowski, D., Annane, D., Cardiomyopathy in Duchenne muscular dystrophy: pathogenesis and therapeutics (2010) Heart Fail Rev, 15, pp. 103-107
dc.descriptionMorine, K.J., Bish, L.T., Selsby, J.T., Gazzara, J.A., Pendrak, K., Sleeper, M.M., Activin IIB receptor blockade attenuates dystrophic pathology in a mouse model of Duchenne muscular dystrophy (2010) Muscle Nerve, 42, pp. 722-730
dc.descriptionSpurney, C.F., Cardiomyopathy of Duchenne Muscular Dystrophy: current understanding and future directions (2011) Muscle Nerve, 44, pp. 8-19
dc.descriptionMinagar, A., Alexander, J.S., Schwendimann, R.N., Kelley, R.E., Gonzalez-Toledo, E., Jimenez, J.J., Combination therapy with interferon beta-1a and doxycycline in multiple sclerosis: an open-label trial (2008) Arch Neurol, 65, pp. 199-204
dc.descriptionLindeman, J.H., Abdul-Hussien, H., van Bockel, J.H., Wolterbeek, R., Kleemann, R., Clinical trial of doxycycline for matrix metalloproteinase-9 inhibition in patients with an abdominal aneurysm: doxycycline selectively depletes aortic wall neutrophils and cytotoxic T cells (2009) Circulation, 119, pp. 2209-2216
dc.descriptionBrown, D.L., Desai, K.K., Vakili, B.A., Nouneh, C., Lee, H.M., Golub, L.M., Clinical and biochemical results of the metalloproteinase inhibition with subantimicrobial doses of doxycycline to prevent acute coronary syndromes (MIDAS) pilot trial (2004) Arterioscler Thromb Vasc Biol, 24, pp. 733-738
dc.descriptionErrami, M., Galindo, C.L., Tassa, A.T., DiMaio, J.M., Hill, J.A., Garner, H.R., Doxycycline attenuates isoproterenol- and transverse aortic banding-induced cardiac hypertrophy in mice (2008) J Pharmacol Exp Ther, 324, pp. 1196-1203
dc.descriptionPierno, S., Nico, B., Burdi, R., Liantonio, A., Didonna, M.P., Cippone, V., Role of tumor necrosis factor alpha, but not of cyclo-oxygenase-2-derived eicosanoids, on functional and morphological indices of dystrophic progression in mdx mice: a pharmacological approach (2007) Neuropathol Appl Neurobiol, 33, pp. 344-359
dc.descriptionMarques, M.J., Machado, R.V., Minatel, E., Santo Neto, H., Disodium cromoglycate protects dystrophin-deficient muscle fibers from leakiness (2008) Muscle Nerve, 37, pp. 61-67
dc.languageen
dc.publisher
dc.relationMuscle and Nerve
dc.rightsfechado
dc.sourceScopus
dc.titleDoxycycline Ameliorates The Dystrophic Phenotype Of Skeletal And Cardiac Muscles In Mdx Mice
dc.typeArtículos de revistas


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