Suramin Affects Metalloproteinase-9 Activity And Increases Beta-dystroglycan Levels In The Diaphragm Of The Dystrophin-deficient Mdx Mouse

dc.creatorTaniguti A.P.T.
dc.creatorMatsumura C.Y.
dc.creatorRodrigues-Simioni L.
dc.creatorNeto H.S.
dc.creatorMarques M.J.
dc.date2012
dc.date2015-06-25T20:25:38Z
dc.date2015-11-26T15:21:40Z
dc.date2015-06-25T20:25:38Z
dc.date2015-11-26T15:21:40Z
dc.date.accessioned2018-03-28T22:31:07Z
dc.date.available2018-03-28T22:31:07Z
dc.identifier
dc.identifierMuscle And Nerve. , v. 46, n. 5, p. 810 - 813, 2012.
dc.identifier0148639X
dc.identifier10.1002/mus.23468
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84867383138&partnerID=40&md5=8676eb8d565d0a636846bc49fd53a749
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/90496
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/90496
dc.identifier2-s2.0-84867383138
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1260263
dc.descriptionIntroduction: In Duchenne muscular dystrophy and in the mdx mouse, muscle fiber degeneration and subsequent fibrosis lead to cardiorespiratory failure. Previously, we demonstrated that the anti-fibrotic agent suramin was effective in decreasing fibrosis in mdx muscles. In this study, we were interested to see whether suramin could affect metalloproteinases (MMP) and improve the functional activity of the mdx diaphragm muscle. Methods: Zymography was performed to evaluate MMP-2 and MMP-9 activity. Western blotting was used to analyze the levels of beta-dystroglycan. Muscle function was assessed in hemidiaphragm in vitro preparations. Results: We found that suramin affects metalloproteinase-9 activity and increases beta-dystroglycan. Furthermore, suramin also protects against diaphragm muscle fatigue over time. Conclusions: These results show the potential benefits of suramin in maintaining the structure of the dystrophin-glycoprotein complex. © 2012 Wiley Periodicals, Inc.
dc.description46
dc.description5
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dc.languageen
dc.publisher
dc.relationMuscle and Nerve
dc.rightsfechado
dc.sourceScopus
dc.titleSuramin Affects Metalloproteinase-9 Activity And Increases Beta-dystroglycan Levels In The Diaphragm Of The Dystrophin-deficient Mdx Mouse
dc.typeArtículos de revistas


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