Antiretroviral Drug Resistance In Brazilian Children Infected By Human Immunodeficiency Virus Type 1

dc.creatorBismara B.A.
dc.creatorAnjos E.B.
dc.creatorAndrade P.D.
dc.creatorAlbuquerque D.M.
dc.creatorSilva M.T.
dc.creatorVilela M.M.
dc.creatorCosta S.C.
dc.date2012
dc.date2015-06-25T20:24:49Z
dc.date2015-11-26T15:20:36Z
dc.date2015-06-25T20:24:49Z
dc.date2015-11-26T15:20:36Z
dc.date.accessioned2018-03-28T22:30:07Z
dc.date.available2018-03-28T22:30:07Z
dc.identifier
dc.identifierJournal Of Antivirals And Antiretrovirals. , v. 4, n. 4, p. 66 - 74, 2012.
dc.identifier19485964
dc.identifier10.4172/jaa.1000048
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84872055425&partnerID=40&md5=a74f9a2d7fdaac4f8e669997604a966c
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/90310
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/90310
dc.identifier2-s2.0-84872055425
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1260027
dc.descriptionThe purpose is to determine the prevalence of drug-resistance mutations in HIV-1 infected children under antiretroviral treatment from Brazil. Blood samples from sixty one human immunodeficiency virus type 1 (HIV-1) vertically-infected Brazilian children are studied. DNA was extracted from the samples, and a 1.0 kb fragment containing HIV-1 PR and RT-coding sequence were amplified by Nested Polymerase Chain Reaction sequencing. The HIV-1 sequencing, based on the polymerase gene sequences (protease and reverse transcriptase regions), was as follows; subtype B (83.6%), subtype F (9.8%) and B/F viral recombinant forms (6.6%). Two major protease inhibitor-resistance associated mutations, M36I and L90M, were most prevalent in our samples (32.8%), as well as the polymorphism L63P (42.6%). Many mutations associated with reduced susceptibility to nucleoside or nonnucleoside reverse-transcriptase inhibitors were detected: M184V (42.6%), M41L (37.7%), D67N (26.2 %), T215Y (24.6%), L210W (21%). This study showed that 85.2% of the studied population showed evidence of therapy failure, with the presence of viral genomic mutations associated with drug resistance. © 2012 Bismara BA, et al.
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dc.descriptionHertogs, K., de Béthune, M.P., Miller, V., Ivens, T., Schel, P., A rapid method for simultaneous detection of phenotypic resistance to inhibitors of protease and reverse transcriptase in recombinant human immunodeficiency virus type 1 isolates from patients treated with antiretroviral drugs (1998) Antimicrob Agents Chemother, 42, pp. 269-272
dc.descriptionKanki, P.J., Hamel, D.J., Sankalé, J.L., Hsieh, C., Thior, I., Human immunodeficiency virus type 1 subtypes differ in disease progression (1999) J Infect Dis, 179, pp. 68-73
dc.descriptionCaride, E., Brindeiro, R., Hertogs, K., Larder, B., Dehertogh, P., Drugresistant reverse transcriptase genotyping and phenotyping of B and non-B subtypes (F and A) of human immunodeficiency virus type I found in Brazilian patients failing HAART (2000) Virology, 275, pp. 107-115
dc.descriptionKaleebu, P., French, N., Mahe, C., Yirrell, D., Watera, C., Effect of human immunodeficiency virus (HIV) type 1 envelope subtypes A and D on disease progression in a large cohort of HIV-1-positive persons in Uganda (2002) J Infect Dis, 185, pp. 1244-1250
dc.descriptionBaxter, J.D., Mayers, D.L., Wentworth, D.N., Neaton, J.D., Hoover, M.L., A randomized study of antiretroviral management based on plasma genotypic antiretroviral resistance testing in patients failing therapy. CPCRA 046 Study Team for the Terry Beirn Community Programs for Clinical Research on AIDS (2000) AIDS, 14, pp. F83-F93
dc.descriptionHirsch, M.S., Conway, B., D'Aquila, R.T., Johnson, V.A., Brun-Vézinet, F., Antiretroviral drug resistance testing in adults with HIV infection: Implications for clinical management. International AIDS Society--USA Panel (1998) JAMA, 279, pp. 1984-1991
dc.descriptionShafer, R.W., Kozal, M.J., Winters, M.A., Iversen, A.K., Katzenstein, D.A., Combination therapy with zidovudine and didanosine selects for drug-resistant human immunodeficiency virus type 1 strains with unique patterns of pol gene mutations (1994) J Infect Dis, 169, pp. 722-729
dc.descriptionVella, S., Palmisano, L., Antiretroviral therapy: State of the HAART (2000) Antiviral Res, 45, pp. 1-7
dc.descriptionMansky, L.M., Retrovirus Mutation Rates and their Role in Genetic Variation (1998) J Gen Virol, 79, pp. 1337-1345
dc.descriptionSimoni, J.M., Frick, P.A., Pantalone, D.W., Turner, B.J., Antiretroviral adherence interventions: A review of current literature and ongoing studies (2003) Top HIV Med, 11, pp. 185-198
dc.descriptionCerqueira, D.M., Amorim, R.M., Silva, R.R., Camara, G.N., Brígido, M.M., Antiretroviral resistance and genetic diversity of human immunodeficiency virus type 1 isolates from the Federal District, Central Brazil (2004) Mem Inst Oswaldo Cruz, 99, pp. 877-882
dc.descriptionThomson, M.M., Pérez-Alvarez, L., Nájera, R., Molecular epidemiology of HIV-1 genetic forms and its significance for vaccine development and therapy (2002) Lancet Infect Dis, 2, pp. 461-471
dc.descriptionPerrin, L., Kaiser, L., Yerly, S., Travel and the spread of HIV-1 genetic variants (2003) Lancet Infect Dis, 3, pp. 22-27
dc.descriptionLittle, S.J., Holte, S., Routy, J.P., Daar, E.S., Markowitz, M., Antiretroviraldrug resistance among patients recently infected with HIV (2002) N Engl J Med, 347, pp. 385-394
dc.descriptionHirsch, M.S., Brun-Vézinet, F., Clotet, B., Conway, B., Kuritzkes, D.R., Antiretroviral drug resistance testing in adults infected with human immunodeficiency virus type 1: 2003 recommendations of an International AIDS Society-USA Panel (2003) Clin Infect Dis, 37, pp. 113-128
dc.descriptionDumans, A.T., Soares, M.A., Pieniazek, D., Kalish, M.L., de Vroey, V., Prevalence of protease and reverse transcriptase drug resistance mutations over time in drug-naïve human immunodeficiency virus type 1-positive individuals in Rio de Janeiro, Brazil (2002) Antimicrob Agents Chemother, 46, pp. 3075-3079
dc.descriptionTanuri, A., Caridea, E., Dantas, M.C., Morgado, M.G., Mello, D.L., Prevalence of mutations related to HIV-1 antiretroviral resistance in Brazilian patients failing HAART (2002) J Clin Virol, 25, pp. 39-46
dc.descriptionShafer, R.W., (2004) Genotypic Testing For HIV-1 Drug Resistance
dc.descriptionNájera, I., Holguín, A., Quiñones-Mateu, M.E., Muñoz-Fernández, M.A., Nájera, R., Pol gene quasispecies of human immunodeficiency virus: Mutations associated with drug resistance in virus from patients undergoing no drug therapy (1995) J Virol, 69, pp. 23-31
dc.descriptionSimonetti, S.R., Schatzmayr, H.G., Simonetti, J.P., Human immunodeficiency virus type 1: Drug resistance in treated and untreated Brazilian children (2003) Mem Inst Oswaldo Cruz, 98, pp. 831-837
dc.descriptionRhee, S.Y., Gonzales, M.J., Kantor, R., Betts, B.J., Ravela, J., Human immunodeficiency virus reverse transcriptase and protease sequence database (2003) Nucleic Acids Res, 31, pp. 298-303
dc.descriptionJohnson, V.A., Brun-Vézinet, F., Clotet, B., Conway, B., D'Aquila, R.T., Drug resistance mutations in HIV-1 (2003) Top HIV Med, 11, pp. 215-221
dc.descriptionHolguín, A., Alvarez, A., Soriano, V., High prevalence of HIV-1 subtype G and natural polymorphisms at the protease gene among HIV-infected immigrants in Madrid (2002) AIDS, 16, pp. 1163-1170
dc.descriptionMitsuya, H., Yarchoan, R., Broder, S., Molecular targets for AIDS therapy (1990) Science, 249, pp. 1533-1544
dc.descriptionDetels, R., Tarwater, P., Phair, J.P., Margolick, J., Riddler, S.A., (2001) Effectiveness of Potent Antiretroviral Therapies On the Incidence of Opportunistic Infections Before and After AIDS Diagnosis, 15, pp. 347-355
dc.descriptionMarins, J.R., Jamal, L.F., Chen, S.Y., Barros, M.B., Hudes, E.S., Dramatic improvement in survival among adult Brazilian AIDS patients (2003) AIDS, 17, pp. 1675-1682
dc.descriptionVella, S., Antiretroviral drug resistance and HIV/AIDS in the developing world (2002) J HIV Ther, 7, pp. 53-55
dc.descriptionDurant, J., Clevenberg, P., Halfon, P., Delgiudice, P., Porsin, S., Drug-Resistance Genotyping in HIV-1 Therapy (1999) Lancet, 354, pp. 2195-2199
dc.descriptionCohen, N.J., Oram, R., Elsen, C., Englund, J.A., Response to changes in antiretroviral therapy after genotyping in human immunodeficiency virusinfected children (2002) Pediatr Infect Dis J, 21, pp. 647-653
dc.descriptionVillalba, N., Gómez-Cano, M., Holguín, A., Soriano, V., Multiple drug resistance genotype causing failure of antiretroviral treatment in an HIVinfected patient heavily exposed to nucleoside analogues (1999) Eur J Clin Microbiol Infect Dis, 18, pp. 372-375
dc.descriptionRossini, M.A., Diaz, R.S., Caseiro, M., Turcato, G., Accetturi, C.A., HIV-1 subtypes among intravenous drug users from two neighboring cities in São Paulo State, Brazil (2001) Braz J Med Biol Res, 34, pp. 45-47
dc.descriptionMorgado, M.G., Guimarães, M.L., Galvão-Castro, B., HIV-1 polymorphism: A challenge for vaccine development a review (2002) Mem Inst Oswaldo Cruz, 97, pp. 143-150
dc.descriptionGadelha, S.R., Shindo, N., Cruz, J.N., Morgado, M.G., Galvão-Castro, B., Molecular epidemiology of human immunodeficiency virus-1 in the state of Ceará, Northeast, Brazil (2003) Mem Inst Oswaldo Cruz, 98, pp. 461-463
dc.descriptionSoares, E.A., Santos, R.P., Pellegrini, J.A., Sprinz, E., Tanuri, A., Epidemiologic and molecular characterization of human immunodeficiency virus type 1 in southern Brazil (2003) J Acquir Immune Defic Syndr, 34, pp. 520-526
dc.descriptionCouto-Fernandez, J.C., Silva-de-Jesus, C., Veloso, V.G., Rachid, M., Gracie, R.S., Human immunodeficiency virus type 1 (HIV-1) genotyping in Rio de Janeiro, Brazil: Assessing subtype and drug-resistance associated mutations in HIV-1 infected individuals failing highly active antiretroviral therapy (2005) Mem Inst Oswaldo Cruz, 100, pp. 73-78
dc.descriptionRamos, A., Tanuri, A., Schechter, M., Rayfield, M.A., Hu, D.J., Dual and recombinant infections: An integral part of the HIV-1 epidemic in Brazil (1999) Emerg Infect Dis, 5, pp. 65-74
dc.descriptionCerqueira, D.M., Ramalho, E.D., Oliveira, C.P., Silva, R.R., Franchini, M., HIV-1 subtypes and mutations associated to antiretroviral drug resistance in human isolates from Central Brazil (2004) Brazilian Journal of Microbiology, p. 35
dc.descriptionWainberg, M.A., White, A.J., Current insights into reverse transcriptase inhibitor-associated resistance (2001) Antivir Ther, 6, pp. 11-19
dc.descriptionLarder, B.A., Kemp, S.D., Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT) (1989) Science, 246, pp. 1155-1158
dc.descriptionRichman, D.D., Resistance of clinical isolates of human immunodeficiency virus to antiretroviral agents (1993) Antimicrob Agents Chemother, 37, pp. 1207-1213
dc.descriptionRichman, D.D., Meng, T.C., Spector, S.A., Fischl, M.A., Resnick, L., Resistance to AZT and ddC during long-term combination therapy in patients with advanced infection with human immunodeficiency virus (1994) J Acquir Immune Defic Syndr, 7, pp. 135-138
dc.descriptionBrun-Vézinet, F., Boucher, C., Loveday, C., Descamps, D., Fauveau, V., HIV-1 viral load, phenotype, and resistance in a subset of drug-naive participants from the Delta trial. The National Virology Groups. Delta Virology Working Group and Coordinating Committee (1997) Lancet, 350, pp. 983-990
dc.descriptionRey, D., Hughes, M., Pi, J.T., Winters, M., Merigan, T.C., HIV-1 reverse transcriptase codon 215 mutation in plasma RNA: Immunologic and virologic responses to zidovudine. The AIDS Clinical Trials Group Study 175 Virology Team (1998) J Acquir Immune Defic Syndr Hum Retrovirol, 17, pp. 203-208
dc.descriptionJapour, A.J., Welles, S., D'Aquila, R.T., Johnson, V.A., Richman, D.D., Prevalence and clinical significance of zidovudine resistance mutations in human immunodeficiency virus isolated from patients after long-term zidovudine treatment. AIDS Clinical Trials Group 116B/117 Study Team and the Virology Committee Resistance Working Group (1995) J Infect Dis, 174, pp. 1172-1179
dc.descriptionDeeks, S.G., Nonnucleoside Reverse Transcriptase Inhibitor Resistance (2001) JAIDS, 26, pp. S25-S33
dc.descriptionHavlir, D.V., Hellmann, N.S., Petropoulos, C.J., Whitcomb, J.M., Collier, A.C., Drug susceptibility in HIV infection after viral rebound in patients receiving indinavir-containing regimens (2000) JAMA, 283, pp. 229-234
dc.descriptionWainberg, M.A., Salomon, H., Gu, Z., Montaner, J.S., Cooley, T.P., Development of HIV-1 resistance to (-)2'-deoxy-3'-thiacytidine in patients with AIDS or advanced AIDS-related complex (1995) AIDS, 9, pp. 351-357
dc.descriptionWainberg, M.A., The impact of the M184V substitution on drug resistance and viral fitness (2004) Expert Rev Anti Infect Ther, 2, pp. 147-151
dc.descriptionBrindeiro, R.M., Diaz, R.S., Sabino, E.C., Morgado, M.G., Pires, I.L., Brazilian Network for HIV Drug Resistance Surveillance (HIV-BResNet): A survey of chronically infected individuals (2003) AIDS, 17, pp. 1063-1069
dc.descriptionBrenner, B., Wainberg, M.A., Salomon, H., Rouleau, D., Dascal, A., Resistance to antiretroviral drugs in patients with primary HIV-1 infection. Investigators of the Quebec Primary Infection Study (2000) Int J Antimicrob Agents, 16, pp. 429-434
dc.descriptionBrindeiro, P.A., Brindeiro, R.M., Mortensen, C., Hertogs, K., de Vroey, V., Testing genotypic and phenotypic resistance in human immunodeficiency virus type 1 isolates of clade B and other clades from children failing antiretroviral therapy (2002) J Clin Microbiol, 40, pp. 4512-4519
dc.descriptionPersaud, D., Siberry, G.K., Ahonkhai, A., Kajdas, J., Monie, D., Continued production of drug-sensitive human immunodeficiency virus type 1 in children on combination antiretroviral therapy who have undetectable viral loads (2004) J Virol, 78, pp. 968-979
dc.descriptionFiscus, S.A., Kovacs, A., Petch, L.A., Hu, C., Wiznia, A.A., Baseline resistance to nucleoside reverse transcriptase inhibitors fails to predict virologic response to combination therapy in children (PACTG 338) (2007) AIDS Res Ther, 4, p. 2
dc.languageen
dc.publisher
dc.relationJournal of Antivirals and Antiretrovirals
dc.rightsfechado
dc.sourceScopus
dc.titleAntiretroviral Drug Resistance In Brazilian Children Infected By Human Immunodeficiency Virus Type 1
dc.typeArtículos de revistas


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