The Hyperinsulinemia Produced By Concanavalin A In Rats Is Opioid- Dependent And Hormonally Regulated

dc.creatorFrancisco-Doprado J.
dc.creatorZambelli J.E.
dc.creatorMelo-Lima M.H.
dc.creatorRibeiro-Dasilva G.
dc.date1998
dc.date2015-06-30T15:07:21Z
dc.date2015-11-26T15:20:19Z
dc.date2015-06-30T15:07:21Z
dc.date2015-11-26T15:20:19Z
dc.date.accessioned2018-03-28T22:29:48Z
dc.date.available2018-03-28T22:29:48Z
dc.identifier
dc.identifierBrazilian Journal Of Medical And Biological Research. , v. 31, n. 5, p. 697 - 703, 1998.
dc.identifier0100879X
dc.identifier
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-0031832005&partnerID=40&md5=d290af8b03b2dbffc53f9ad7f419d0c5
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/100731
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/100731
dc.identifier2-s2.0-0031832005
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1259948
dc.descriptionThe present study examines the effect of concanavalin A (Con A) on the blood insulin and glucose levels of rats. Male and female rats treated with Con A (62.5-500 μg/kg) for three days sowed a dose- and time-dependent hyperinsulinemia that listed more than 48 h. Male rats were more sensitive to Con A. Thus, 6 h after treatment with Con A the circulating insulin levels in male rats had increased by 85% (control: 10.2 ± 0.9 mU/l and Con A-treated: 10.3 ± mU/l) in females. An identical response was seen after 12 h. Con A (250 μg/kg) produced time-dependent hypoglycemia in both sexes but more pronounced in males. There was no correlation between the hypoglycemia and hyperinsulinemia described above. The Con A-induced hyperinsulinemia in rats of both sexes was abolished in gonadectomized animals, P<0.05) while testosterone (10 mg/kg, im) had no similar effect on intact female rats. Pretreating Con A-injected rats with opioid antagonists such as naloxone (1 mg/kg, sc) and naltrexone (5 mg/kg, sc) blocked the hyperinsulinemia produced by the lectin in males (control: +101 ± 17% vs naloxone-treated: +5 ± 14%, or naltrexone-treated: -23 ± 4.5%) and females (control: +86 ± 23% vs naloxone-treated: +21 ± 20%, or naltrexone-treated: -18 ± 11%). These results demonstrates that Con A increases the levels of circulating insulin in rats and that this response is opioid-dependent and hormonally regulated.
dc.description31
dc.description5
dc.description697
dc.description703
dc.languageen
dc.publisher
dc.relationBrazilian Journal of Medical and Biological Research
dc.rightsaberto
dc.sourceScopus
dc.titleThe Hyperinsulinemia Produced By Concanavalin A In Rats Is Opioid- Dependent And Hormonally Regulated
dc.typeArtículos de revistas


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