| dc.creator | Leiria L.O.S. | |
| dc.creator | Martins M.A. | |
| dc.creator | Saad M.J.A. | |
| dc.date | 2015 | |
| dc.date | 2015-06-25T12:55:42Z | |
| dc.date | 2015-11-26T15:20:17Z | |
| dc.date | 2015-06-25T12:55:42Z | |
| dc.date | 2015-11-26T15:20:17Z | |
| dc.date.accessioned | 2018-03-28T22:29:46Z | |
| dc.date.available | 2018-03-28T22:29:46Z | |
| dc.identifier | | |
| dc.identifier | Metabolism: Clinical And Experimental. W.b. Saunders, v. 64, n. 2, p. 172 - 181, 2015. | |
| dc.identifier | 260495 | |
| dc.identifier | 10.1016/j.metabol.2014.10.002 | |
| dc.identifier | http://www.scopus.com/inward/record.url?eid=2-s2.0-84920561939&partnerID=40&md5=9551de13cc78a4cc9308726cb605cc3a | |
| dc.identifier | http://www.repositorio.unicamp.br/handle/REPOSIP/85636 | |
| dc.identifier | http://repositorio.unicamp.br/jspui/handle/REPOSIP/85636 | |
| dc.identifier | 2-s2.0-84920561939 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1259942 | |
| dc.description | Obesity is a major risk factor for asthma. Likewise, obesity is known to increase disease severity in asthmatic subjects and also to impair the efficacy of first-line treatment medications for asthma, worsening asthma control in obese patients. This concept is in agreement with the current understanding that some asthma phenotypes are not accompanied by detectable inflammation, and may not be ameliorated by classical anti-inflammatory therapy. There are growing evidences suggesting that the obesity-related asthma phenotype does not necessarily involve the classical TH2-dependent inflammatory process. Hormones involved in glucose homeostasis and in the pathogeneses of obesity likely directly or indirectly link obesity and asthma through inflammatory and non-inflammatory pathways. Furthermore, the endocrine regulation of the airway-related pre-ganglionic nerves likely contributes to airway hyperreactivity (AHR) in obese states. In this review, we focused our efforts on understanding the mechanism underlying obesity-related asthma by exploring the TH2-independent mechanisms leading to this disease. | |
| dc.description | 64 | |
| dc.description | 2 | |
| dc.description | 172 | |
| dc.description | 181 | |
| dc.description | Ford, E.S., The epidemiology of obesity and asthma (2005) J Allergy Clin Immunol, 115, pp. 897-909 | |
| dc.description | Taylor, B., Mannino, D., Brown, C., Crocker, D., Twum-Baah, N., Holguin, F., Body mass index and asthma severity in the National Asthma Survey (2008) Thorax, 63, pp. 14-20 | |
| dc.description | Popkin, B.M., Global nutrition dynamics: The world is shifting rapidly toward a diet linked with noncommunicable diseases (2006) Am J Clin Nutr, 84, pp. 289-298 | |
| dc.description | Akerman, M.J., Calacanis, C.M., Madsen, M.K., Relationship between asthma severity and obesity (2004) J Asthma, 41, pp. 521-526 | |
| dc.description | Peters-Golden, M., Swern, A., Bird, S.S., Hustad, C.M., Grant, E., Edelman, J.M., Influence of body mass index on the response to asthma controller agents (2006) Eur Respir J, 27, pp. 495-503 | |
| dc.description | Sutherland, E.R., Lehman, E.B., Teodorescu, M., Wechsler, M.E., National Heart, Lung, and Blood Institute's Asthma Clinical Research Network. Body mass index and phenotype in subjects with mild-to-moderate persistent asthma (2009) J Allergy Clin Immunol, 123, pp. 1328-1334 | |
| dc.description | Camargo, C.A., Jr., Boulet, L.P., Sutherland, E.R., Busse, W.W., Yancey, S.W., Emmett, A.H., Body mass index and response to asthma therapy: Fluticasone propionate/salmeterol versus montelukast (2010) J Asthma, 47, pp. 76-82 | |
| dc.description | Telenga, E.D., Tideman, S.W., Kerstjens, H.A., Hacken, N.H., Timens, W., Postma, D.S., Obesity in asthma: More neutrophilic inflammation as a possible explanation for a reduced treatment response (2012) Allergy, 67, pp. 1060-1068 | |
| dc.description | Locksley, R.M., Asthma and allergic inflammation (2010) Cell, 140, pp. 777-783 | |
| dc.description | Wenzel, S.E., Asthma phenotypes: The evolution from clinical to molecular approaches (2012) Nat Med, 18, pp. 716-725 | |
| dc.description | King, G.G., Brown, N.J., Diba, C., Thorpe, C.W., Muñoz, P., Marks, G.B., The effects of body weight on airway calibre (2005) Eur Respir J, 25, pp. 896-901 | |
| dc.description | Chapman, D.G., Berend, N., King, G.G., Salome, C.M., Increased airway closure is a determinant of airway hyperresponsiveness (2008) Eur Respir J, 32, pp. 1563-1569 | |
| dc.description | Farah, C.S., Kermode, J.A., Downie, S.R., Brown, N.J., Hardaker, K.M., Berend, N., Obesity is a determinant of asthma control independent of inflammation and lung mechanics (2011) Chest, 140, pp. 659-666 | |
| dc.description | Lessard, A., Turcotte, H., Cormier, Y., Boulet, L.P., Obesity and asthma: A specific phenotype? (2008) Chest, 134, pp. 317-323 | |
| dc.description | Todd, D.C., Armstrong, S., D'Silva, L., Allen, C.J., Hargreave, F.E., Parameswaran, K., Effect of obesity on airway inflammation: A cross-sectional analysis of body mass index and sputum cell counts (2007) Clin Exp Allergy, 37, pp. 1049-1054 | |
| dc.description | Sutherland, T.J., Cowan, J.O., Young, S., Goulding, A., Grant, A.M., Williamson, A., The association between obesity and asthma: Interactions between systemic and airway inflammation (2008) Am J Respir Crit Care Med, 178, pp. 469-475 | |
| dc.description | Shore, S.A., Obesity and asthma: Location, location, location (2013) Eur Respir J, 41, pp. 253-254 | |
| dc.description | Sideleva, O., Suratt, B.T., Black, K.E., Tharp, W.G., Pratley, R.E., Forgione, P., Obesity and asthma: An inflammatory disease of adipose tissue not the airway (2012) Am J Respir Crit Care Med, 186, pp. 598-605 | |
| dc.description | Camargo, C.A., Jr., Sutherland, E.R., Bailey, W., Castro, M., Yancey, S.W., Emmett, A.H., Effect of increased body mass index on asthma risk, impairment and response to asthma controller therapy in African Americans (2010) Curr Med Res Opin, 26, pp. 1629-1635 | |
| dc.description | Arteaga-Solis, E., Zee, T., Emala, C.W., Vinson, C., Wess, J., Karsenty, G., Inhibition of leptin regulation of parasympathetic signaling as a cause of extreme body weight-associated asthma (2013) Cell Metab, 17, pp. 35-48 | |
| dc.description | Scott, H.A., Gibson, P.G., Garg, M.L., Wood, L.G., Airway inflammation is augmented by obesity and fatty acids in asthma (2011) Eur Respir J, 38, pp. 594-602 | |
| dc.description | Desai, D., Newby, C., Symon, F.A., Haldar, P., Shah, S., Gupta, S., Elevated sputum interleukin-5 and submucosal eosinophilia in obese individuals with severe asthma (2013) Am J Respir Crit Care Med, 188, pp. 657-663 | |
| dc.description | Grotta, M.B., Squebola-Cola, D.M., Toro, A.A., Ribeiro, M.A., Mazon, S.B., Ribeiro, J.D., Obesity increases eosinophil activity in asthmatic children and adolescents (2013) BMC Pulm Med, 13, p. 39 | |
| dc.description | Calixto, M.C., Lintomen, L., Schenka, A., Saad, M.J., Zanesco, A., Antunes, E., Obesity enhances eosinophilic inflammation in a murine model of allergic asthma (2010) Br J Pharmacol, 159, pp. 617-625 | |
| dc.description | Mito, N., Kitada, C., Hosoda, T., Sato, K., Effect of diet-induced obesity on ovalbumin-specific immune response in a murine asthma model (2002) Metabolism, 51, pp. 1241-1246 | |
| dc.description | Lintomen, L., Calixto, M.C., Schenka, A., Antunes, E., Allergen-induced bone marrow eosinophilopoiesis and airways eosinophilic inflammation in leptin-deficient ob/ob mice (2012) Obesity (Silver Spring), 20, pp. 1959-1965 | |
| dc.description | Lloyd, C.M., Saglani, S., Eosinophils in the Spotlight: Finding the link between obesity and asthma (2013) Nat Med, 19, pp. 976-977 | |
| dc.description | Boulet, L.P., Asthma and obesity (2013) Clin Exp Allergy, 43, pp. 8-21 | |
| dc.description | Barnes, P.J., Adcock, I.M., Glucocorticoid resistance in inflammatory diseases (2009) Lancet, 373, pp. 1905-1917 | |
| dc.description | Boulet, L.P., Franssen, E., Influence of obesity on response to fluticasone with or without salmeterol in moderate asthma (2007) Respir Med, 101, pp. 2240-2247 | |
| dc.description | Nie, Z., Jacoby, D.B., Fryer, A.D., Hyperinsulinemia potentiates airway responsiveness to parasympathetic nerve stimulation in obese rats (2014) Am J Respir Cell Mol Biol | |
| dc.description | Al-Alwan, A., Bates, J.H., Chapman, D.G., Kaminsky, D.A., Desarno, M.J., Irvin, C.G., The nonallergic asthma of obesity. A matter of distal lung compliance (2014) Am J Respir Crit Care Med, 189, pp. 1494-1502 | |
| dc.description | Dixon, A.E., Pratley, R.E., Forgione, P.M., Kaminsky, D.A., Whittaker-Leclair, L.A., Griffes, L.A., Effects of obesity and bariatric surgery on airway hyperresponsiveness, asthma control, and inflammation (2011) J Allergy Clin Immunol, 128, pp. 508-515 | |
| dc.description | Scherer, P.E., Williams, S., Fogliano, M., Baldini, G., Lodish, H.F., A novel serum protein similar to C1q, produced exclusively in adipocytes (1995) J Biol Chem, 270, pp. 26746-26749 | |
| dc.description | Schraw, T., Wang, Z.V., Halberg, N., Hawkins, M., Scherer, P.E., Plasma adiponectin complexes have distinct biochemical characteristics (2008) Endocrinology, 149 (5), pp. 2270-2282 | |
| dc.description | Tsao, T.S., Murrey, H.E., Hug, C., Lee, D.H., Lodish, H.F., Oligomerization state-dependent activation of NF-kappa B signaling pathway by adipocyte complement-related protein of 30 kDa (Acrp30) (2002) J Biol Chem, 277, pp. 29359-29362 | |
| dc.description | Yamauchi, T., Kamon, J., Ito, Y., Tsuchida, A., Yokomizo, T., Kita, S., Cloning of adiponectin receptors that mediate antidiabetic metabolic effects (2003) Nature, 423, pp. 762-769 | |
| dc.description | Berg, A.H., Combs, T.P., Du, X., Brownlee, M., Scherer, P.E., The adipocyte-secreted protein Acrp30 enhances hepatic insulin action (2001) Nat Med, 7, pp. 947-953 | |
| dc.description | Pajvani, U.B., Du, X., Combs, T.P., Berg, A.H., Rajala, M.W., Schulthess, T., Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications for metabolic regulation and bioactivity (2003) J Biol Chem, 278, pp. 9073-9085 | |
| dc.description | Waki, H., Yamauchi, T., Kamon, J., Ito, Y., Uchida, S., Kita, S., Impaired multimerization of human adiponectin mutants associated with diabetes. Molecular structure and multimer formation of adiponectin (2003) J Biol Chem, 278, pp. 40352-40363 | |
| dc.description | Kadowaki, T., Yamauchi, T., Kubota, N., Hara, K., Ueki, K., Tobe, K., Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome (2006) J Clin Invest, 116, pp. 1784-1792 | |
| dc.description | Li, S., Shin, H.J., Ding, E.L., Van Dam, R.M., Adiponectin levels and risk of type 2 diabetes: A systematic review and meta-analysis (2009) JAMA, 302, pp. 179-188 | |
| dc.description | Pajvani, U.B., Hawkins, M., Combs, T.P., Rajala, M.W., Doebber, T., Berger, J.P., Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity (2004) J Biol Chem, 279, pp. 12152-12162 | |
| dc.description | Yamauchi, T., Nio, Y., Maki, T., Kobayashi, M., Takazawa, T., Iwabu, M., Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions (2007) Nat Med, 13, pp. 332-339 | |
| dc.description | Williams, A.S., Kasahara, D.I., Verbout, N.G., Fedulov, A.V., Zhu, M., Si, H., Role of the adiponectin binding protein, T-cadherin(Cdh13), in allergic airways responses in mice (2012) PLoS One, 7, p. 41088 | |
| dc.description | Medoff, B.D., Okamoto, Y., Leyton, P., Weng, M., Sandall, B.P., Raher, M.J., Adiponectin deficiency increases allergic airway inflammation and pulmonary vascular remodeling (2009) Am J Respir Cell Mol Biol, 41, pp. 397-406 | |
| dc.description | Kasahara, D.I., Kim, H.Y., Williams, A.S., Verbout, N.G., Tran, J., Si, H., Pulmonary inflammation induced by subacute ozone is augmented in adiponectin-deficient mice: Role of IL-17A (2012) J Immunol, 188, pp. 4558-4567 | |
| dc.description | Fahy, J.V., Kim, K.W., Liu, J., Boushey, H.A., Prominent neutrophilic inflammation in sputum from subjects with asthma exacerbation (1995) J Allergy Clin Immunol, 95, pp. 843-852 | |
| dc.description | Ordonez, C.L., Shaughnessy, T.E., Matthay, M.A., Fahy, J.V., Increased neutrophil numbers and il-8 levels in airway secretions in acute severe asthma: Clinical and biologic significance (2000) Am J Respir Crit Care Med, 161, pp. 1185-1190 | |
| dc.description | Zhu, X.L., Qin, X.Q., Xiang, Y., Tan, Y.R., Qu, X.P., Liu, H.J., Adipokine adiponectin is a potential protector to human bronchial epithelial cell for regulating proliferation, wound repair and apoptosis: Comparison with leptin and resistin (2013) Peptides, 40, pp. 34-41 | |
| dc.description | Jartti, T., Saarikoski, L., Jartti, L., Lisinen, I., Jula, A., Huupponen, R., Obesity, adipokines and asthma (2009) Allergy, 64, pp. 770-777 | |
| dc.description | Holguin, F., Rojas, M., Brown, L.A., Fitzpatrick, A.M., Airway and plasma leptin and adiponectin in lean and obese asthmatics and controls (2011) J Asthma, 48, pp. 217-223 | |
| dc.description | Aydin, M., Koca, C., Ozol, D., Uysal, S., Yildirim, Z., Kavakli, H.S., Interaction of metabolic syndrome with asthma in postmenopausal women: Role of adipokines (2013) Inflammation, 36, pp. 1232-1238 | |
| dc.description | Sood, A., Qualls, C., Schuyler, M., Thyagarajan, B., Steffes, M.W., Smith, L.J., Low serum adiponectin predicts future risk for asthma in women (2012) Am J Respir Crit Care Med, 186, pp. 41-47 | |
| dc.description | Schwartz, M.W., Porte, D., Jr., Diabetes, obesity, and the brain (2005) Science, 307, pp. 375-379 | |
| dc.description | Elmquist, J.K., Coppari, R., Balthasar, N., Ichinose, M., Lowell, B.B., Identifying hypothalamic pathways controlling food intake, body weight, and glucose homeostasis (2005) J Comp Neurol, 493, pp. 63-71 | |
| dc.description | Campfield, L.A., Smith, F.J., Guisez, Y., Devos, R., Burn, P., Recombinant mouse OB protein: Evidence for a peripheral signal linking adiposity and central neural networks (1995) Science, 269, pp. 546-549 | |
| dc.description | Tartaglia, L.A., Dembski, M., Weng, X., Deng, N., Culpepper, J., Devos, R., Identification and expression cloning of a leptin receptor, OB-R (1995) Cell, 83, pp. 1263-1271 | |
| dc.description | Montague, C.T., Farooqi, I.S., Whitehead, J.P., Soos, M.A., Rau, H., Wareham, N.J., Congenital leptin deficiency is associated with severe early-onset obesity in humans (1997) Nature, 387, pp. 903-908 | |
| dc.description | Clément, K., Vaisse, C., Lahlou, N., Cabrol, S., Pelloux, V., Cassuto, D., A mutation in the humanleptin receptor gene causes obesity and pituitary dysfunction (1998) Nature, 392, pp. 398-401 | |
| dc.description | Myers, M.G., Jr., Olson, D.P., Central nervous system control of metabolism (2012) Nature, 491, pp. 357-363 | |
| dc.description | Zamorano, P.L., Mahesh, V.B., De Sevilla, L.M., Chorich, L.P., Bhat, G.K., Brann, D.W., Expression and localization of the leptin receptor in endocrine and neuroendocrine tissues of the rat (1997) Neuroendocrinology, 65, pp. 223-228 | |
| dc.description | Fei, H., Okano, H.J., Li, C., Lee, G.H., Zhao, C., Darnell, R., Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues (1997) Proc Natl Acad Sci U S A, 94, pp. 7001-7005 | |
| dc.description | Cohen, P., Zhao, C., Cai, X., Montez, J.M., Rohani, S.C., Feinstein, P., Selective deletion of leptin receptor in neurons leads to obesity (2001) J Clin Invest, 108, pp. 1113-1121 | |
| dc.description | De Luca, C., Kowalski, T.J., Zhang, Y., Elmquist, J.K., Lee, C., Kilimann, M.W., Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes (2005) J Clin Invest, 115, pp. 3484-3493 | |
| dc.description | Li, B., Shi, Z., Cassaglia, P.A., Brooks, V.L., Leptin acts in the forebrain to differentially influence baroreflex control of lumbar, renal, and splanchnic sympathetic nerve activity and heart rate (2013) Hypertension, 61, pp. 812-819 | |
| dc.description | Després, J.P., Lemieux, I., Abdominal obesity and metabolic syndrome (2006) Nature, 444, pp. 881-887 | |
| dc.description | Saad, M.J., Carvalheira, J.B., Velloso, L.A., Birth weight and type 2 diabetes in adults (2009) JAMA, 301, p. 1539 | |
| dc.description | Tsukumo, D.M., Carvalho-Filho, M.A., Carvalheira, J.B., Prada, P.O., Hirabara, S.M., Schenka, A.A., Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance (2007) Diabetes, 56, pp. 1986-1998 | |
| dc.description | Milanski, M., Degasperi, G., Coope, A., Morari, J., Denis, R., Cintra, D.E., Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: Implications for the pathogenesis of obesity (2009) J Neurosci, 29, pp. 359-370 | |
| dc.description | Thuesen, B.H., Husemoen, L.L., Hersoug, L.G., Pisinger, C., Linneberg, A., Insulin resistance as a predictor of incident asthma-like symptoms in adults (2009) Clin Exp Allergy, 39, pp. 700-707 | |
| dc.description | Arshi, M., Cardinal, J., Hill, R.J., Davies, P.S., Wainwright, C., Asthma and insulin resistance in children (2010) Respirology, 15, pp. 779-784 | |
| dc.description | Vikram, A., Jena, G.B., Ramarao, P., Increased cell proliferation and contractility of prostate in insulin resistant rats: Linking hyperinsulinemia with benign prostate hyperplasia (2010) Prostate, 70, pp. 79-89 | |
| dc.description | Carvalho, C.R., Carvalheira, J.B., Lima, M.H., Zimmerman, S.F., Caperuto, L.C., Amanso, A., Novel signal transduction pathway for luteinizing hormone and its interaction with insulin: Activation of Janus kinase/signal transducer and activator of transcription and phosphoinositol 3-kinase/Akt pathways (2003) Endocrinology, 144, pp. 638-647 | |
| dc.description | Zecchin, H.G., Priviero, F.B., Souza, C.T., Zecchin, K.G., Prada, P.O., Carvalheira, J.B., Defective insulin and acetylcholine induction of endothelial cell-nitric oxide synthase through insulin receptor substrate/Akt signaling pathway in aorta of obese rats (2007) Diabetes, 56, pp. 1014-1024 | |
| dc.description | Contreras, C., Sánchez, A., Martínez, P., Raposo, R., Climent, B., García-Sacristán, A., Insulin resistance in penile arteries from a rat model of metabolic syndrome (2010) Br J Pharmacol, 161, pp. 350-364 | |
| dc.description | Leiria, L.O., Sollon, C., Báu, F.R., Mónica, F.Z., D'Ancona, C.L., De Nucci, G., Insulin relaxes bladder via PI3K/AKT/eNOS pathway activation in mucosa: Unfolded protein response-dependent insulin resistance as a cause of obesity-associated overactive bladder (2013) J Physiol, 591, pp. 2259-2273 | |
| dc.description | Scherrer, U., Randin, D., Vollenweider, P., Vollenweider, L., Nicod, P., Nitric oxide release accounts for insulin's vascular effects in humans (1994) J Clin Invest, 94, pp. 2511-2515 | |
| dc.description | Lee, J.H., Ragolia, L., AKT phosphorylation is essential for insulin-induced relaxation of rat vascular smooth muscle cells (2006) Am J Physiol Cell Physiol, 291, pp. C1355-C1365 | |
| dc.description | Dimmeler, S., Fleming, I., Fisslthaler, B., Hermann, C., Busse, R., Zeiher, A.M., Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation (1999) Nature, 399, pp. 601-605 | |
| dc.description | Belmonte, K.E., Jacoby, D.B., Fryer, A.D., Increased function of inhibitory neuronal M2 muscarinic receptors in diabetic rat lungs (1997) Br J Pharmacol, 121, pp. 1287-1294 | |
| dc.description | Schaafsma, D., Gosens, R., Ris, J.M., Zaagsma, J., Meurs, H., Nelemans, S.A., Insulin induces airway smooth muscle contraction (2007) Br J Pharmacol, 150, pp. 136-142 | |
| dc.description | Cavalher-Machado, S.C., De Lima, W.T., Damazo, A.S., De Frias Carvalho, V., Martins, M.A., Silva, P.M.E., Down-regulation of mast cell activation and airway reactivity in diabetic rats: Role of insulin (2004) Eur Respir J, 24, pp. 552-558 | |
| dc.description | Belmonte, K.E., Fryer, A.D., Costello, R.W., Role of insulin in antigen-induced airway eosinophilia and neuronal M2 muscarinic receptor dysfunction (1998) J Appl Physiol, 85, pp. 1708-1718 | |
| dc.description | Douek, I.F., Leech, N.J., Gillmor, H.A., Bingley, P.J., Gale, E.A., Children with type-1 diabetes and their unaffected siblings have fewer symptoms of asthma (1999) Lancet, 353, p. 1850 | |
| dc.description | Filippi, B.M., Yang, C.S., Tang, C., Lam, T.K., Insulin activates Erk1/2 signaling in the dorsal vagal complex to inhibit glucose production (2012) Cell Metab, 16, pp. 500-510 | |
| dc.description | Kc, P., Martin, R.J., Role of central neurotransmission and chemoreception on airway control (2010) Respir Physiol Neurobiol, 173, pp. 213-222 | |
| dc.description | Oliveira, A.G., Araujo, T.G., Carvalho, B.M., Guadagnini, D., Rocha, G.Z., Bagarolli, R.A., Acute exercise induces a phenotypic switch in adipose tissue macrophage polarization in diet-induced obese rats (2013) Obesity (Silver Spring), 21, pp. 2545-2556 | |
| dc.description | Clària, J., González-Périz, A., López-Vicario, C., Rius, B., Titos, E., New insights into the role of macrophages in adipose tissue inflammation and fatty liver disease: Modulation by endogenous omega-3 Fatty Acid-derived lipid mediators (2011) Front Immunol, 2, p. 49 | |
| dc.description | Hotamisligil, G.S., Peraldi, P., Budavari, A., Ellis, R., White, M.F., Spiegelman, B.M., IRS- 1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha-and obesity-induced insulin resistance (2006) Science, 271, pp. 665-668 | |
| dc.description | Hotamisligil, G.S., Inflammation and metabolic disorders (2006) Nature, 444, pp. 860-867 | |
| dc.description | Williams, A.S., Chen, L., Kasahara, D.I., Si, H., Wurmbrand, A.P., Shore, S.A., Obesity and airway responsiveness: Role of TNFR2 (2013) Pulm Pharmacol Ther, 26, pp. 444-454 | |
| dc.description | Lugogo, N.L., Hollingsworth, J.W., Howell, D.L., Que, L.G., Francisco, D., Church, T.D., Alveolar macrophages from overweight/obese subjects with asthma demonstrate a proinflammatory phenotype (2012) Am J Respir Crit Care Med, 186, pp. 404-411 | |
| dc.description | Coccia, M., Harrison, O.J., Schiering, C., Asquith, M.J., Becher, B., Powrie, F., IL-1beta mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4(1) Th17 cells (2012) J Exp Med, 209, pp. 1595-1609 | |
| dc.description | Kudo, M., Melton, A.C., Chen, C., Engler, M.B., Huang, K.E., Ren, X., IL-17A produced by alphabeta T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction (2012) Nat Med, 18, pp. 547-554 | |
| dc.description | Kim, H.Y., Lee, H.J., Chang, Y.J., Pichavant, M., Shore, S.A., Fitzgerald, K.A., Interleukin-17-producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity (2014) Nat Med, 20, pp. 54-61 | |
| dc.description | Kasahara, D.I., Kim, H.Y., Mathews, J.A., Verbout, N.G., Williams, A.S., Wurmbrand, A.P., Pivotal role of IL-6 in the hyperinflammatory responses to subacute ozone in adiponectin deficient mice (2014) Am J Physiol Lung Cell Mol Physiol, 306, pp. L508-L520 | |
| dc.description | Calixto, M.C., Lintomen, L., André, D.M., Metformin attenuates the exacerbation of the allergic eosinophilic inflammation in high fat-diet-induced obesity in mice (2013) PLoS One, 8, p. 76786 | |
| dc.language | en | |
| dc.publisher | W.B. Saunders | |
| dc.relation | Metabolism: Clinical and Experimental | |
| dc.rights | fechado | |
| dc.source | Scopus | |
| dc.title | Obesity And Asthma: Beyond Th2 Inflammation | |
| dc.type | Artículos de revistas | |
