Cephalosporin C Production And Genetic Improvement Of The Fungus Acremonium Chrysogenum Based On Morphological Mutant Isolation

dc.creatorVialta A.
dc.creatorCatani C.F.
dc.creatorJunior R.B.
dc.creatorAzevedo J.L.
dc.date1997
dc.date2015-06-30T14:47:49Z
dc.date2015-11-26T15:20:01Z
dc.date2015-06-30T14:47:49Z
dc.date2015-11-26T15:20:01Z
dc.date.accessioned2018-03-28T22:29:31Z
dc.date.available2018-03-28T22:29:31Z
dc.identifier
dc.identifierBrazilian Journal Of Genetics. , v. 20, n. 2, p. 165 - 170, 1997.
dc.identifier1008455
dc.identifier
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-0030791918&partnerID=40&md5=0e8205fc6203a0d6384fe92e14735ecc
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/100019
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/100019
dc.identifier2-s2.0-0030791918
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1259876
dc.descriptionC-10 strain of the fungus Acremonium chrysogenum produced about 1.5 g/l of cephalosporin C, a yield that was much lower than expected according to the literature. This discrepancy, confirmed by exhaustive tests, showed that C-10 strain lost its high cephalosporin C production ability, probably due to genetic events. Strain improvement, based on isolation of morphologically compact mutant colonies, confirmed that this is a useful procedure for isolation of strains with increased titer. About 2% of tested colonies produced significantly more cephalosporin C than the original strain.
dc.description20
dc.description2
dc.description165
dc.description170
dc.descriptionBaldwin, J.E., Bird, J.W., Field, R.A., O'Calaghan, N., Schofield, C.J., Isolation and partial characterization of ACV synthetase from Cephalosporium ammonium and Streptomyces clavuligerus (1990) J. Antibiot., 18, pp. 1055-1057
dc.descriptionBall, C., Improvement of penicillin productivity in Penicillium chrysogenum by recombination (1973) Genetics of Industrial Microorganisms, 2, pp. 227-237. , (Vanek, Z., Hostalek, Z. and Cudlin, J., eds.). Elsevier Publishing Co., Amsterdam
dc.descriptionBall, C., Hamlyn, P.F., The genetics of Acremonium chrysogenum (1978) Rev. Bras. Genet., 1, pp. 83-96
dc.descriptionChang, L.T., Elander, R.P., Rational selection for improved cephalosporin C productivity in strains of Acremoninm chrysogenum Gams (1979) Dev. Ind. Microbiol., 20, pp. 367-379
dc.descriptionChapman, J.L., Skatrud, P.L., Ingolia, T.D., Samson, S.M., Kaster, K.R., Queener, S.W., Recombinant DNA studies in Cephalosporium ammonium (1987) Dev. Ind. Microbiol., 27, pp. 165-174
dc.descriptionHamlyn, P.F., Birkett, J.A., Perez, G., Peberdy, J.F., Protoplast fusion as a tool for genetic analysis in Cephalosporium acremonium (1985) J. Gen. Microbiol., 131, pp. 2813-2823
dc.descriptionHoskins, J.A., O'Callaghan, N., Queener, S.W., Cantwell, C.A., Wood, J.S., Chen, V.J., Skatrud, P.L., Gene disruption of the pcb AB gene encoding ACV synthetase in Cephalosporium acremonium (1990) Curr. Genet., 18, pp. 523-530
dc.descriptionLein, J., Strain development with non-recombinant DNA techniques (1983) ASM News, 49, pp. 576-579
dc.descriptionMacDonald, K.D., Degeneration of penicillin titre in cultures of Penicillium chrysogenum (1968) Nature, 218, pp. 371-372
dc.descriptionMilles, G.L., Use of dinitrosalicylic acid reagent for determination of reducing sugar (1959) Anal. Chem., 31, pp. 426-428
dc.descriptionNüesch, J., Treichler, H.J., Liersch, M., The biosynthesis of cephalosporin C (1973) Genetics of Industrial Microorganisms, pp. 309-334. , (Vanek, Z., Hostalek, Z. and Cudlin, J., eds.). Elsevier Publishing Co., Amsterdam
dc.descriptionPan, C.H., Speth, S.V., McKillip, E., Nach, C.H., Methyl oleate-based fermentation medium for cephalosporin C production (1982) Dev. Ind. Microbiol., 23, pp. 315-323
dc.descriptionPeberdy, J.F., Genetics of Acremonium (1987) Penicillium and Acremonium - Biotechnology Handbooks, 1. , (Peberdy, J.F., ed.). Plenum Press, New York
dc.descriptionSamson, S.M., Belagaje, R., Blankenship, D.T., Chapman, J.L., Perry, D., Skatrud, P.L., Vanfrank, R.M., Ingolia, T.D., Isolation, sequence determination and expression in E. coli of the isopenicillin N synthetase gene from Cephalosporium acremonium (1985) Nature, 318, pp. 191-194
dc.descriptionSamson, S.M., Dotzlaf, J.E., Slisz, M.L., Becker, G.W., Van Frank, R.M., Veal, L.E., Yeh, W.K., Ingolia, T.D., Cloning and expression of the fungal expandase/hydroxylase gene envolved in cephalosporin biosynthesis (1987) Biotechnology, 5, pp. 1207-1214
dc.descriptionShen, Y.Q., Wolfe, S., Demain, A.L., Levels of isopenicillin N synthetase in Cephalosporium acremonium producing high and low levels of cephalosporin C (1986) Biotechnology, 4, pp. 61-64
dc.descriptionSiegel, S., (1975) Estatística Não Paramétrica para As Ciências Do Comportamento, , McGraw Hill do Brasil, São Paulo
dc.descriptionSimpson, I.N., Caten, C.E., Induced quantitative variation for penicillin titre in clonal populations of Aspergillus nidulans (1979) J. Gen. Microbiol., 110, pp. 1-12
dc.descriptionSkatrud, P.L., Queener, S.W., An electrophoretic molecular karyotype for an industrial strain of Cephalosporium acremonium (1989) Gene, 79, pp. 331-338
dc.descriptionSkatrud, P.L., Queener, S.W., Carr, L.G., Fisher, D.L., Efficient integrative transformation of Cephalosporium acremonium (1987) Curr. Genet., 22, pp. 337-348
dc.descriptionSkatrud, P.L., Tietz, A.J., Ingolia, T.D., Cantwell, C.A., Fisher, D.L., Chapman, J.L., Queener, S.W., Use of recombinant DNA to improve production of cephalosporin C by Cephalosporium acremonium (1989) Biotechnology, 7, pp. 477-485
dc.descriptionSmith, A., Cephalosporins (1985) Comprehensive Biotechnology, 3. , (Moo-Young, M., Bull, A.T. and Dalton, H., eds.). Pergamon Press, Oxford
dc.descriptionSmith, A.W., Collis, K., Ramsden, M., Fox, H.M., Peberdy, J.F., Chromosome rearrangements in improved cephalosporin C-producing strains of Acremonium chrysogenum (1991) Curr. Genet., 19, pp. 235-237
dc.descriptionSmith, A.W., Ramsden, M., Peberdy, J.F., Analysis of promoter activity by transformation of Acremonium chrysogenum (1992) Gene, 114, pp. 211-216
dc.descriptionSteel, R.G.D., Torrie, J.H., (1960) Principles and Procedures of Statistics, , MacGraw Hill Book Co. Inc., New York
dc.descriptionTrilli, A., Michelini, V., Mantovani, V., Pirt, S.J., Development of an agar disk method for the rapid selection of cephalosporin producers with improved yields (1978) Antimicrob. Agents Chemother., 13, pp. 7-15
dc.descriptionWalz, M., Kück, U., Polymorphic karyotypes in related Acremonium strains (1991) Curr. Genet., 19, pp. 73-76
dc.languageen
dc.publisher
dc.relationBrazilian Journal of Genetics
dc.rightsaberto
dc.sourceScopus
dc.titleCephalosporin C Production And Genetic Improvement Of The Fungus Acremonium Chrysogenum Based On Morphological Mutant Isolation
dc.typeArtículos de revistas


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