dc.creator | Volobuef C. | |
dc.creator | Moraes C.M. | |
dc.creator | Nunes L.A.S. | |
dc.creator | Cereda C.M.S. | |
dc.creator | Yokaichiya F. | |
dc.creator | Franco M.K.K.D. | |
dc.creator | Braga A.F.A. | |
dc.creator | de Paula E. | |
dc.creator | Tofoli G.R. | |
dc.creator | Fraceto L.F. | |
dc.creator | de Araujo D.R. | |
dc.date | 2012 | |
dc.date | 2015-06-25T20:24:27Z | |
dc.date | 2015-11-26T15:19:57Z | |
dc.date | 2015-06-25T20:24:27Z | |
dc.date | 2015-11-26T15:19:57Z | |
dc.date.accessioned | 2018-03-28T22:29:27Z | |
dc.date.available | 2018-03-28T22:29:27Z | |
dc.identifier | | |
dc.identifier | Journal Of Pharmaceutical Sciences. , v. 101, n. 10, p. 3698 - 3707, 2012. | |
dc.identifier | 223549 | |
dc.identifier | 10.1002/jps.23234 | |
dc.identifier | http://www.scopus.com/inward/record.url?eid=2-s2.0-84865384414&partnerID=40&md5=ebd7beef1569df0e41ab79de5046ed9b | |
dc.identifier | http://www.repositorio.unicamp.br/handle/REPOSIP/90226 | |
dc.identifier | http://repositorio.unicamp.br/jspui/handle/REPOSIP/90226 | |
dc.identifier | 2-s2.0-84865384414 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1259858 | |
dc.description | Sufentanil (SUF) is a synthetic analgesic opioid widely used for the management of acute and chronic pain. This drug was complexed with 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) and the physicochemical characterization, in vitro/ex vivo toxicity assays, and pharmacological evaluation were performed. Differential scanning calorimetry, Fourier transform infrared spectroscopy (FTIR) analysis, and X-ray powder diffraction showed the formation and the morphology of the complex. Nuclear magnetic resonance afforded data regarding inclusion complex stoichiometry (1:1) with an association binding constant (Ka) value of 515.2 ± 1.2M-1 between SUF and HP-β-CD. Complexation with HP-β-CD protected SUF from light exposure and increased its photostability. Release kinetics revealed a decrease in SUF release rate (Krel = 7.05 ± 0.52 and 5.61 ± 0.39min-1/2 for SUF-HP-β-CD and SUF, respectively) and reduced hemolytic or myotoxic effects after complexation. Time course of tail-flick test showed that the duration of analgesia induced by SUF (150.0 ± 34.6min) was significantly increased (p < 0.001) after complexation with HP-β-CD (355.7 ± 47.2min) when injected at the same dose (1μg kg-1), prolonging the duration of analgesia after intramuscular administration and representing an alternative on the development of effective and safe drug-delivery system for opioid analgesics. © 2012 Wiley Periodicals, Inc. | |
dc.description | 101 | |
dc.description | 10 | |
dc.description | 3698 | |
dc.description | 3707 | |
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dc.language | en | |
dc.publisher | | |
dc.relation | Journal of Pharmaceutical Sciences | |
dc.rights | fechado | |
dc.source | Scopus | |
dc.title | Sufentanil-2-hydroxypropyl-β-cyclodextrin Inclusion Complex For Pain Treatment: Physicochemical, Cytotoxicity, And Pharmacological Evaluation | |
dc.type | Artículos de revistas | |