Decreased Tnf-α Gene Expression In Periodontal Ligature In Msg-obese Rats: A Possible Protective Effect Of Hypothalamic Obesity Against Periodontal Disease?

dc.creatorBrandelero Jr. S.
dc.creatorBonfleur M.L.
dc.creatorRibeiro R.A.
dc.creatorVanzela E.C.
dc.creatorNassar C.A.
dc.creatorNassar P.O.
dc.creatorBalbo S.L.
dc.date2012
dc.date2015-06-25T20:24:21Z
dc.date2015-11-26T15:19:54Z
dc.date2015-06-25T20:24:21Z
dc.date2015-11-26T15:19:54Z
dc.date.accessioned2018-03-28T22:29:23Z
dc.date.available2018-03-28T22:29:23Z
dc.identifier
dc.identifierArchives Of Oral Biology. , v. 57, n. 3, p. 300 - 306, 2012.
dc.identifier39969
dc.identifier10.1016/j.archoralbio.2011.08.024
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84857633621&partnerID=40&md5=962730c21c383a2300169687d3015cd6
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/90203
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/90203
dc.identifier2-s2.0-84857633621
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1259848
dc.descriptionThe prevalence of obesity is increasing globally. There is evidence that the uncontrolled energetic metabolism in obese patients can accelerate periodontal disease. Therefore, the aim of this study was evaluate the possible relationship between hypothalamic obesity induced by neonatal treatment with MSG and experimental periodontal disease. Newborn male Wistar rats received subcutaneous injections in the cervical region, of 4g/Kg/day of body weight (BW) of MSG (MSG group) or hypertonic saline solution, 1.25/kg/day BW (control group, CTL). At 70 days of life periodontal disease was induced in these animals. After they were sacrificed, radiographic analyses of alveolar bone resorption and Tumor Necrosis Factor α (TNFα) gene expression in gingival tissue were performed. The neonatal treatment with MSG did not affect the concentration of plasma glucose and cholesterol (CHOL). However, plasma insulin, non-esterified fatty acids (NEFA) and triglycerides (TG) leves were higher in MSG compared with CTL group. The alveolar bone resorption was 44% lower in MSG-obese rats compared with CTL rats. In the presence of periodontal ligature, there was an increase in this parameter in all groups. The TNFα gene expression, an inflammatory marker, in periodontal tissue was similar in obese and CTL rats. The presence of ligature increased TNFα gene expression in both groups, but in a lower extension in MSG-obese rats. In conclusion these results suggested that hypothalamic obesity may produce a protective effect against periodontal disease, however further research is needed to understand the mechanisms involved in this process. © 2011 Elsevier Ltd.
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dc.languageen
dc.publisher
dc.relationArchives of Oral Biology
dc.rightsfechado
dc.sourceScopus
dc.titleDecreased Tnf-α Gene Expression In Periodontal Ligature In Msg-obese Rats: A Possible Protective Effect Of Hypothalamic Obesity Against Periodontal Disease?
dc.typeArtículos de revistas


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