Thymidylate Synthase Gene (tyms) Polymorphisms In Sporadic And Hereditary Breast Cancer

dc.creatorDa Silva Nogueira Junior J.
dc.creatorDe Lima Marson F.A.
dc.creatorBertuzzo C.S.
dc.date2012
dc.date2015-06-25T20:24:22Z
dc.date2015-11-26T15:19:53Z
dc.date2015-06-25T20:24:22Z
dc.date2015-11-26T15:19:53Z
dc.date.accessioned2018-03-28T22:29:23Z
dc.date.available2018-03-28T22:29:23Z
dc.identifier
dc.identifierBmc Research Notes. , v. 5, n. , p. - , 2012.
dc.identifier17560500
dc.identifier10.1186/1756-0500-5-676
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84872377152&partnerID=40&md5=700a4f19238888ad534fa2213245c5df
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/90209
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/90209
dc.identifier2-s2.0-84872377152
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1259846
dc.descriptionBackground: Breast cancer (BC) is a genetic disorder characterized by growth and proliferation of breast cells in a disorderly. In Brazil, there are approximately 49.240 new cases of BC, every year. The BC etiology is still poorly understood. The BC can be sporadic (SBC) or hereditary (HBC). Recent studies have correlated gene polymorphisms with the BC, such as alterations in thymidylate synthase gene (TYMS), which are used to improve diagnosis and prevention of the disease. Polymorphisms in the TYMS gene 5'-UTR region, usually present reps double (2R) and/or triple (3R). Studies have shown that homozygous 3R/3R is overexpressed compared with 2R/2R genotype, and these polymorphic variations may contribute to individual susceptibility to the development of BC. In this context, the objective of this study was to evaluate the frequency of the TYMS 2R and 3R polymorphisms, comparing genotypic and allelic distribution with SBC and HBC patients. Methods. In this study we included a total of 204 subjects, 70 with BC (33 with SBC, and 37 with HBC) and 134 healthy subjects (controls). The Polymerase Chain Reaction was the method used. Results: Results demonstrated a high frequency of the 3R allele at BC, SBC, and HBC groups. The frequency of genotype 2R/3R was significantly higher in BC group. This work showed association between the 2R/3R variants (OR = 4.14, CI95% = 1.77-9.71) in the development of SBC, and 2R/2R (OR = 0.233, CI95% = 1.63-7.65) and 2R/3R (OR = 3.53, CI95% = 0.06-0.81) for developing HBC. To BC, there was association with the genotype 2R/3R (OR: 3.79, CI95% = 2.03-7.08). Conclusion: Our results show relation to the development of BC in association with the analyzed polymorphisms. © 2012 Junior et al.; licensee BioMed Central Ltd.
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dc.languageen
dc.publisher
dc.relationBMC Research Notes
dc.rightsfechado
dc.sourceScopus
dc.titleThymidylate Synthase Gene (tyms) Polymorphisms In Sporadic And Hereditary Breast Cancer
dc.typeArtículos de revistas


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