Gene Expression Profiling In Genetic Animal Models Of Provide Elements To Unveil The Molecular Mechanisms Underlying Epileptogenesis In Rodents [a Caracterização Do Perfil De Expressão Gênica Em Larga Escala Em Modelos Genéticos De Epilepsia Fornece Elementos Para Entender Os Mecanismos Envolvidos Na Epileptogênese Em Roedores]

dc.creatorMatos A.H.B.
dc.creatorPascoal V.D.B.
dc.creatorNascimento D.R.
dc.creatorMartins S.
dc.creatorRocha C.S.
dc.creatorVasconcellos J.F.
dc.creatorChamma M.T.
dc.creatorMaurer-Morelli C.V.
dc.creatorMartins A.S.
dc.creatorValle A.C.
dc.creatorGodard A.L.B.
dc.creatorLopes Cendes I.
dc.date2012
dc.date2015-06-25T20:24:02Z
dc.date2015-11-26T15:19:32Z
dc.date2015-06-25T20:24:02Z
dc.date2015-11-26T15:19:32Z
dc.date.accessioned2018-03-28T22:29:04Z
dc.date.available2018-03-28T22:29:04Z
dc.identifier
dc.identifierJournal Of Epilepsy And Clinical Neurophysiology. , v. 18, n. 2, p. 50 - 52, 2012.
dc.identifier16762649
dc.identifier10.1590/S1676-26492012000200006
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84872563714&partnerID=40&md5=c42951859824f8d6df3c8177781fc0e7
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/90138
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/90138
dc.identifier2-s2.0-84872563714
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1259771
dc.descriptionObjective: The objective of this study was to characterize and compare the genetic profile of two rodent models of epilepsy (Wistar Audiogenic Rat - WAR and rats with generalized epilepsy with absence seizures-GEAS) using gene expression analysis Methods: We used microarray technology for gene expression analysis. Results: The analysis of gene expression profiles in WAR showed among genes up-regulated Neurod1, involved in the development of the cochlear duct. In addition, we found significant differences in gene expression of Apbb1, Foxg1 and Scn1A. GEAS rats had differentially expressed genes related to the development of central nervous system, as well as genes involved in the MAPK pathway, transcription factors, neuronal migration and apoptosis. Conclusion: This study may help to clarify the underlying molecular mechanism that leads to the predisposition to seizures in these animals. Our results indicate the activation of distinct molecular pathways in both models.
dc.description18
dc.description2
dc.description50
dc.description52
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dc.languagept
dc.publisher
dc.relationJournal of Epilepsy and Clinical Neurophysiology
dc.rightsaberto
dc.sourceScopus
dc.titleGene Expression Profiling In Genetic Animal Models Of Provide Elements To Unveil The Molecular Mechanisms Underlying Epileptogenesis In Rodents [a Caracterização Do Perfil De Expressão Gênica Em Larga Escala Em Modelos Genéticos De Epilepsia Fornece Elementos Para Entender Os Mecanismos Envolvidos Na Epileptogênese Em Roedores]
dc.typeArtículos de revistas


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