Immunohistochemical Study Of Basement Membrane Collagen Iv In Uterine Cervix Carcinoma.

dc.creatorPinto G.A.
dc.creatorVassallo J.
dc.creatorAndrade L.A.
dc.creatorMagna L.A.
dc.date1998
dc.date2015-06-30T15:07:05Z
dc.date2015-11-26T15:19:15Z
dc.date2015-06-30T15:07:05Z
dc.date2015-11-26T15:19:15Z
dc.date.accessioned2018-03-28T22:28:47Z
dc.date.available2018-03-28T22:28:47Z
dc.identifier
dc.identifierSão Paulo Medical Journal = Revista Paulista De Medicina. , v. 116, n. 6, p. 1846 - 1851, 1998.
dc.identifier15163180
dc.identifier
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-0032198038&partnerID=40&md5=02467a4d29d59a10ee602445f113505e
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/100706
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/100706
dc.identifier2-s2.0-0032198038
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1259701
dc.descriptionCONTEXT: The integrity of basement membrane (BM) is damaged during the evolution of a benign or potentially malignant lesion into a malignant one, in which it may undergo several degrees of discontinuity as a necessary condition for the invasive process. Immunostaining for collagen IV, which is exclusively found in BM, has been used to evaluate its formation in neoplastic and benign lesions of several organs. OBJECTIVE: To investigate BM continuity pattern in squamous carcinoma "in situ" (CIS), microinvasive (MIC) and invasive (IC) squamous cell carcinoma of the uterine cervix, and to find out if BM expression could be useful in the diagnosis of early stromal invasion (MIC). DESIGN: Archival material between 1988 and 1993 was studied at the Pathological Anatomy Department-Unicamp. PROCEDURES: The selected cases, previously formalin fixed and paraffin embedded, were reviewed retrospectively by submitting them to immunohistochemical study via the avidin-biotin-peroxidase method using a monoclonal antibody anticollagen IV. RESULTS: In all, 17 cases of CIS, 16 of MIC and 21 of IC were evaluated. All IC cases showed evident BM discontinuity, either focal or diffuse. In the CIS group, a continuous BM pattern was predominant, being focally disrupted in only 2/17 cases (11.8%). The MIC group showed an intermediate pattern, but with a clear tendency to BM discontinuity in 10/16 cases (62.5%). Inflammatory infiltrate, a variable also studied, cannot be considered responsible for BM discontinuity, since there was no statistical correlation between them. CONCLUSION: We conclude that immunostaining for collagen IV may contribute to the diagnosis of stromal invasion by BM discontinuity.
dc.description116
dc.description6
dc.description1846
dc.description1851
dc.languageen
dc.publisher
dc.relationSão Paulo medical journal = Revista paulista de medicina
dc.rightsaberto
dc.sourceScopus
dc.titleImmunohistochemical Study Of Basement Membrane Collagen Iv In Uterine Cervix Carcinoma.
dc.typeArtículos de revistas


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