Understanding The Spectrum Of Temporal Lobe Epilepsy: Contributions For The Development Of Individualized Therapies

dc.creatorCoan A.C.
dc.creatorCendes F.
dc.date2013
dc.date2015-06-25T19:19:06Z
dc.date2015-11-26T15:17:15Z
dc.date2015-06-25T19:19:06Z
dc.date2015-11-26T15:17:15Z
dc.date.accessioned2018-03-28T22:26:58Z
dc.date.available2018-03-28T22:26:58Z
dc.identifier
dc.identifierExpert Review Of Neurotherapeutics. , v. 13, n. 12, p. 1383 - 1394, 2013.
dc.identifier14737175
dc.identifier10.1586/14737175.2013.857604
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84887979597&partnerID=40&md5=5268189d9b71e7d79cdfada0b4d4abf6
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/89880
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/89880
dc.identifier2-s2.0-84887979597
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1259406
dc.descriptionMesial temporal lobe epilepsy (TLE) is a subtype of epilepsy in which individuals present with seizure semiology and electroencephalographic characteristics that point to an ictal onset in mesial temporal structures. The diagnosis of TLE involves different etiologies, the most common being hippocampal sclerosis, but up to 20% of TLE patients have no detectable structural lesions on modern MRIs. A variability of antiepileptic drug response and surgical prognosis is observed in TLE. The understanding of the differences among patients with TLE can facilitate the development of individualized and more efficient therapeutics. In this study, we will address the recent contributions of neuroimaging, neurophysiology, genetics and histopathology to the comprehension of the spectrum of TLE with and without MRI signs of hippocampal sclerosis and how the advances in these areas have helped to improve surgical treatments. © 2013 Informa UK Ltd.
dc.description13
dc.description12
dc.description1383
dc.description1394
dc.descriptionProposal for revised classification of epilepsies and epileptic syndromes: Commission on classification and terminology of the international league against epilepsy (1989) Epilepsia, 30, pp. 389-399. , ILAE ILAE
dc.descriptionHauser, W.A., The natural history of temporal lobe epilepsy (1992) Epilepsy Surgery, pp. 133-141. , Lüders HO (Ed. Raven Press, New York, USA
dc.descriptionKwan, P., Arzimanoglou, A., Berg, A.T., Definition of drug resistant epilepsy: Consensus proposal by the ad hoc task force of the ilae commission on therapeutic strategies (2010) Epilepsia, 51, pp. 1069-1077
dc.descriptionMesial temporal lobe epilepsy with hippocampal sclerosis (2004) Epilepsia, 45, pp. 695-714. , Compiled by Heinz-Gregor Wieser for the ILAE Commission on Neurosurgery of Epilepsy
dc.descriptionAguglia, U., Beghi, E., Labate, A., Age at onset predicts good seizure outcome in sporadic non-lesional and mesial temporal sclerosis based temporal lobe epilepsy (2011) J. Neurol. Neurosurg. Psychiatry, 82, pp. 555-559
dc.descriptionCohen-Gadol, A.A., Bradley, C.C., Williamson, A., Normal magnetic resonance imaging and medial temporal lobe epilepsy: The clinical syndrome of paradoxical temporal lobe epilepsy (2005) J. Neurosurg, 102, pp. 902-909
dc.descriptionBrodie M, J., Barry, S.J.E., Bamagous, G.A., Norrie, J.D., Kwan, P., Patterns of treatment response in newly diagnosed epilepsy (2012) Neurology, 78, pp. 1548-1554
dc.descriptionSemah, F., Picot, M.C., Adam, C., Is the underlying cause of epilepsy a major prognostic factor for recurrence? (1998) Neurology, 51, pp. 1256-1262
dc.descriptionAguglia, U., Gambardella, A., Le Piane, E., Mild non-lesional temporal lobe epilepsy a common unrecognized disorder with onset in adulthood (1998) Can. J. Neurol. Sci, 25, pp. 282-286
dc.descriptionPittau, F., Bisulli, F., Mai, R., Prognostic factors in patients with mesial temporal lobe epilepsy (2009) Epilepsia, 50, pp. 41-44
dc.descriptionGlauser, T., Ben-Menachem, E., Bourgeois, B., ILAE Treatment guidelines: Evidence-based analysis of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes (2006) Epilepsia, 47, pp. 1094-1120
dc.descriptionCendes, F., Andermann, F., Gloor, P., MRI volumetric measurements of amygdala and hipocamppus in temporal lobe epilepsy (1993) Neurology, 43, pp. 719-725
dc.descriptionVan Paesschen, W., Sisodiya, S., Connelly, A., Quantitative hippocampal MRI and intractable temporal lobe epilepsy (1995) Neurology, 45, pp. 2233-2240
dc.descriptionKobayashi, E., Lopes-Cendes, I., Guerreiro, C.A.M., Sousa, S.C., Guerreiro, M.M., Cendes, F., Seizure outcome and hippocampal atrophy in familial mesial temporal lobe epilepsy (2001) Neurology, 56, pp. 166-172
dc.descriptionAndrade-Valenca, L.P., Valenca, M.M., Ribeiro, L.T., Clinical and neuroimaging features of good and poor seizure control patients with mesial temporal lobe epilepsy and hippocampal atrophy (2003) Epilepsia, 44, pp. 807-814
dc.descriptionLabate, A., Ventura, P., Gambardella, A., MRI evidence of mesial temporal sclerosis in sporadic "benign" temporal lobe epilepsy (2006) Neurology, 66, pp. 562-565
dc.descriptionVan Paesschen, W., Connelly, A., King, M.D., Jackson, G.D., Duncan, J.S., The spectrum of hippocampal sclerosis: A quantitative magnetic resonance imaging study (1997) Ann. Neurol, 41, pp. 41-51
dc.descriptionCardoso, T.A.M., Coan, A.C., Kobayashi, E., Guerreiro, C.A.M., Li, L.M., Cendes, F., Hippocampal abnormalities and seizure recurrence after antiepileptic drug withdrawal (2006) Neurology, 67, pp. 134-136
dc.descriptionBonilha, L., Rorden, C., Castellano, G., Voxel-based morphometry reveals gray matter network atrophy in refractory medial temporal lobe epilepsy (2004) Arch. Neurol, 61, pp. 1379-1384
dc.descriptionBernasconi, N., Duchesne, S., Janke, A., Whole-brain voxel-based statistical analysis of gray matter and white matter in temporal lobe epilepsy (2004) Neuroimage, 23, pp. 717-723
dc.descriptionKeller, S.S., Roberts, N., Voxel-based morphometry of temporal lobe epilepsy: An introduction and review of the literature (2007) Epilepsia, 49, pp. 741-757
dc.descriptionCoan, A.C., Appenzeller, S., Bonilha, L., Li, L.M., Cendes, F., Seizure frequency and lateralization affect progression of atrophy in temporal lobe epilepsy (2009) Neurology, 73, pp. 834-842
dc.descriptionBilevicius, E., Yasuda, C.L., Silva, M.S., Guerreiro, C.A.M., Lopes-Cendes, I., Cendes, F., Antiepileptic drug response in temporal lobe epilepsy A clinical and MRI morphometry study (2010) Neurology, 75, pp. 1695-1701
dc.descriptionLabate, A., Cerasa, A., Gambardella, A., Aguglia, U., Quattrone, A., Hippocampal and thalamic atrophy in mild temporal lobe epilepsy A VBM study (2008) Neurology, 71, pp. 1094-1101
dc.descriptionLabate, A., Cerasa, A., Aguglia, U., Mumoli, L., Quattrone, A., Gambardella, A., Neocortical thinning in "benign" mesial temporal lobe epilepsy (2011) Epilepsia, 52, pp. 712-717
dc.descriptionAssaf, B.A., Mohamed, F.B., Abou-Khaled, K.J., Diffusion tensor imaging of the hippocampal formation in temporal lobe epilepsy (2003) Am. J. Neuroradiol, 24, pp. 1857-1862
dc.descriptionArfanakis, K., Hermann, B.P., Rogers, B.P., Carew, J.D., Seidenberg, M., Meyerand, M.E., Diffusion tensor MRI in temporal lobe epilepsy (2002) Magn. Reson. Imaging, 20, pp. 511-519
dc.descriptionThivard, L., Lehéricy, S., Krainik, A., Diffusion tensor imaging in medial temporal lobe epilepsy with hippocampal sclerosis (2005) Neuroimage, 28, pp. 682-690
dc.descriptionConcha, L., Beaulieu, C., Gross, D.W., Bilateral limbic diffusion abnormalities in unilateral temporal lobe epilepsy (2005) Ann. Neurol, 57, pp. 188-196
dc.descriptionGovindan, R.M., Makki, M.I., Sundaram, S.K., Juhász, C., Chugani, H.T., Diffusion tensor analysis of temporal and extra-temporal lobe tracts in temporal lobe epilepsy (2008) Epilepsy Res, 80, pp. 30-41
dc.descriptionConcha, L., Livy, D.J., Beaulieu, C., Wheatley, B.M., Gross, D.W., In vivo diffusion tensor imaging and histopathology of the fimbria-fornix in temporal lobe epilepsy (2010) J. Neurosci, 30, pp. 996-1002
dc.descriptionPittau, F., Grova, C., Moeller, F., Dubeau, F., Gotman, J., Patterns of altered functional connectivity in mesial temporal lobe epilepsy (2012) Epilepsia, 53, pp. 1013-1023
dc.descriptionZhang, Z., Lu, G., Zhong, Y., Altered spontaneous neuronal activity of the default-mode network in mesial temporal lobe epilepsy (2010) Brain Res, 1323, pp. 152-160
dc.descriptionFocke, N.K., Yogarajah, M., Bonelli, S.B., Bartlett, P.A., Symms, M.R., Duncan, J.S., Voxel-based diffusion tensor imaging in patients with mesial temporal lobe epilepsy and hippocampal sclerosis (2008) Neuroimage, 40, pp. 728-737
dc.descriptionKeller, S.S., Cresswell, P., Denby, C., Persistent seizures following left temporal lobe surgery are associated with posterior and bilateral structural and functional brain abnormalities (2007) Epilepsy Res, 74, pp. 131-139
dc.descriptionYasuda, C.L., Valise, C., Pereira, A.R., Dynamic changes in white and gray matter volume are associated with outcome of surgical treatment in temporal lobe epilepsy (2010) Neuroimage, 49, pp. 71-79
dc.descriptionBerg, A.T., Berkovic, S.F., Brodie, M.J., Revised terminology and concepts for organization of seizures and epilepsies: Report of the ILAE commission on classification and terminology 2005 2009 (2010) Epilepsia, 51, pp. 676-685
dc.descriptionMueller, S.G., Laxer, K.D., Cashdollar, N., Buckley, S., Paul, C., Weiner, M.W., Voxel-based optimized morphometry (VBM) of gray and white matter in temporal lobe epilepsy (MTLE) with and without mesial temporal sclerosis (2006) Epilepsia, 47, pp. 900-907
dc.descriptionRiederer, F., Lanzenberger, R., Kaya, M., Prayer, D., Serles, W., Baumgartner, C., Network atrophy in temporal lobe epilepsy: A voxel-based morphometry study (2008) Neurology, 71, pp. 419-425
dc.descriptionConcha, L., Beaulieu, C., Collins, D.L., Gross, D.W., White-matter diffusion abnormalities in temporal-lobe epilepsy with and without mesial temporal sclerosis (2009) J. Neurol. Neurosurg. Psychiatry, 80, pp. 312-319
dc.descriptionKim, C.H., Koo, B.B., Chung, C.K., Lee, J.M., Kim, J.S., Lee, S.K., Thalamic changes in temporal lobe epilepsy with and without hippocampal sclerosis: A diffusion tensor imaging study (2010) Epilepsy Res, 90, pp. 21-27
dc.descriptionMin, L., Concha, L., Lebel, C., Beaulieu, C., Gross, D.W., Mesial temporal sclerosis is linked with more widespread white matter changes in temporal lobe epilepsy (2012) Neuroimage, 1 (1), pp. 99-105
dc.descriptionSiddiqui, A., Kerb, R., Weale, M.E., Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1 (2003) N. Engl. J. Med, 348, pp. 1442-1448
dc.descriptionZimprich, F., Sunder-Plassmann, R., Stogmann, E., Association of an ABCB1 gene haplotype with pharmacoresistance in temporal lobe epilepsy (2004) Neurology, 63, pp. 1087-1089
dc.descriptionTan, N.C.K., Heron, S.E., Scheffer, I.E., Failure to confirm association of a polymorphism in ABCB1 with multidrug-resistant epilepsy (2004) Neurology, 63, pp. 1090-1092
dc.descriptionBournissen, F.G., Moretti, M.E., Juurlink, D.N., Koren, G., Walker, M., Finkelstein, Y., Polymorphism of the MDR1/ ABCB1 C3435T drug-transporter and resistance to anticonvulsant drugs: A meta-analysis (2009) Epilepsia, 50, pp. 898-903
dc.descriptionLabate, A., Gambardella, A., Andermann, E., Benign mesial temporal lobe epilepsy (2011) Nat. Rev. Neurol, 7, pp. 237-240
dc.descriptionMorita, M.E., Yasuda, C.L., Betting, L.E., MRI and EEG as long-term seizure outcome predictors in familial mesial temporal lobe epilepsy (2012) Neurology, 79, pp. 2349-2354
dc.descriptionBerkovic, S.F., McIntosh, A., Howell, R.A., Mitchell, A., Sheffield, L.J., Hopper, J.L., Familial temporal lobe epilepsy: A common disorder identified in twins (1996) Ann. Neurol, 40, pp. 227-235
dc.descriptionKobayashi, E., Li, L.M., Lopes-Cendes, I., Cendes, F., Magnetic resonance imaging evidence of hippocampal sclerosis in asymptomatic, first-degree relatives of patients with familial mesial temporal lobe epilepsy (2002) Arch. Neurol, 59, pp. 1891-1894
dc.descriptionHedera, P., Blair, M.A., Andermann, E., Familial mesial temporal lobe epilepsy maps to chromosome 4q13 2-q21 3 (2007) Neurology, 68, pp. 2107-2112
dc.descriptionMaurer-Morelli, C.V., Secolin, R., Morita, M.E., A locus identified on chromosome18p11 31 is associated with hippocampal abnormalities in a family with mesial temporal lobe epilepsy (2012) Front. Neurol, 3 (124)
dc.descriptionCrompton, D.E., Scheffer, I.E., Taylor, I., Familial mesial temporal lobe epilepsy: A benign epilepsy syndrome showing complex inheritance (2010) Brain, 133, pp. 3221-3231
dc.descriptionVezzani, A., Ravizza, T., Balosso, S., Aronica, E., Glia as a source of cytokines: Implications for neuronal excitability and survival (2008) Epilepsia, 49 (SUPPL. 2), pp. 24-32
dc.descriptionAronica, E., Fluiter, K., Iyer, A., Expression pattern of miR-146a, an inflammation-associated microRNA, in experimental and human temporal lobe epilepsy (2010) Eur. J. Neurosci, 31, pp. 1100-1107
dc.descriptionCrespel, A., Coubes, P., Rousset, M.C., Inflammatory reactions in human medial temporal lobe epilepsy with hippocampal sclerosis (2002) Brain Res, 952, pp. 159-169
dc.descriptionBialer, M., Johannessen, S.I., Levy, R.H., Perucca, E., Tomson, T., White, H.S., Progress report on new antiepileptic drugs: A summary of the eleventh eilat conference (eilat xi (2013) Epilepsy Res, 103, pp. 2-30
dc.descriptionEngel Jr., J., Wiebe, S., French, J., Practice parameter: Temporal lobe and localized neocortical resections for epilepsy: Report of the quality standards subcommittee of the american academy of neurology, in association with the american epilepsy society and the american association of neurological surgeons (2003) Neurology, 60, pp. 538-547
dc.descriptionDe Tisi, J., Bell, G.S., Peacock, J.L., The long-term outcome of adult epilepsy surgery, patterns of seizure remission, and relapse: A cohort study (2011) Lancet, 378, pp. 1388-1395
dc.descriptionBell, M.L., Rao, S., So, E.L., Epilepsy surgery outcomes in temporal lobe epilepsy with a normal MRI (2009) Epilepsia, 50, pp. 2053-2060
dc.descriptionKobayashi, E., D'Agostino, M.D., Lopes-Cendes, I., Outcome of surgical treatment in familial mesial temporal lobe epilepsy (2003) Epilepsia, 44, pp. 1080-1084
dc.descriptionWiebe, S., Blume, W.T., Girvin, J.P., Eliasziw, M., A randomized, controlled trial of surgery for temporal-lobe epilepsy (2001) N. Engl. J. Med, 345, pp. 311-318
dc.descriptionSchramm, J., Temporal lobe epilepsy surgery and the quest for optimal extent of resection: A review (2008) Epilepsia, 49, pp. 1296-1307
dc.descriptionJanszky, J., Janszky, I., Schulz, R., Temporal lobe epilepsy with hippocampal sclerosis: Predictors for long-term surgical outcome (2005) Brain, 128, pp. 395-404
dc.descriptionJeha, L.E., Najm, I.M., Bingaman, W.E., Predictors of outcome after temporal lobectomy for the treatment of intractable epilepsy (2006) Neurology, 66, pp. 1938-1940
dc.descriptionSchulz, R., Lüders, H.O., Hoppe, M., Tuxhorn, I., May, T., Ebner, A., Interictal EEG and ictal scalp EEG propagation are highly predictive of surgical outcome in mesial temporal lobe epilepsy (2000) Epilepsia, 41, pp. 564-570
dc.descriptionKrendl, R., Lurger, S., Baumgartner, C., Absolute spike frequency predicts surgical outcome in MTLE with unilateral hippocampal atrophy (2008) Neurology, 71, pp. 413-418
dc.descriptionWennberg, R., Arruda, F., Quesney, L.F., Olivier, A., Preeminence of extrahippocampal structures in the generation of mesial temporal seizures: Evidence from human depth electrode recordings (2002) Epilepsia, 43, pp. 716-726
dc.descriptionKahane, P., Bartolomei, F., Temporal lobe epilepsy and hippocampal sclerosis: Lessons from depth EEG recordings (2010) Epilepsia, 51 (SUPPL. 1), pp. 59-62
dc.descriptionChabardes, S., Kahane, P., Minotti, L., The temporopolar cortex plays a pivotal role in temporal lobe seizures (2005) Brain, 128, pp. 1818-1831
dc.descriptionAfif, A., Chabardes, S., Minotti, L., Kahane, P., Hoffmann, D., Safety and usefulness of insular depth electrodes implanted via an oblique approach in patients with epilepsy (2008) Neurosurgery, 62, pp. ONS471-ONS480
dc.descriptionBartolomei, F., Cosandier-Rimele, D., McGonigal, A., From mesial temporal lobe to temporoperisylvian seizures: A quantified study of temporal lobe seizure networks (2010) Epilepsia, 51, pp. 2147-2158
dc.descriptionSperling, M.R., Clinical challenges in invasive monitoring in epilepsy surgery (1997) Epilepsia, 38 (SUPPL. 4), pp. S6-S12
dc.descriptionLi, L.M., Cendes, F., Andermann, F., Surgical outcome in patients with epilepsy and dual pathology (1999) Brain, 122, pp. 799-805
dc.descriptionCendes, F., Dubeau, F., Andermann, F., Significance of mesial temporal atrophy in relation to intracranial ictal and interictal stereo EEG abnormalities (1996) Brain, 119, pp. 1317-1326
dc.descriptionKing, D., Spencer, S.S., McCarthy, G., Luby, M., Spencer, D.D., Bilateral hippocampal atrophy in medial temporal lobe epilepsy (1995) Epilepsia, 36 (9), pp. 905-910
dc.descriptionBernasconi, N., Bernasconi, A., Caramanos, Z., Antel, S.B., Andermann, F., Arnold, D.L., Mesial temporal damage in temporal lobe epilepsy: A volumetric MRI study of the hippocampus, amygdala and parahippocampal region (2003) Brain, 126, pp. 462-469
dc.descriptionBonilha, L., Kobayashi, E., Rorden, C., Cendes, F., Li, L.M., Medial temporal lobe atrophy in patients with refractory temporal lobe epilepsy (2003) J. Neurol. Neurosurg. Psychiatry, 74, pp. 1627-1630
dc.descriptionCoste, S., Ryvlin, P., Hermier, M., Temporopolar changes in temporal lobe epilepsy: A quantitative MRI-based study (2002) Neurology, 59, pp. 855-861
dc.descriptionFerreira, F.T., Kobayashi, E., Lopes-Cendes, I., Cendes, F., Structural abnormalities are similar in familial and nonfamilial mesial temporal lobe epilepsy (2004) Can. J. Neurol. Sci, 31, pp. 368-372
dc.descriptionBonilha, L., Yasuda, C.L., Rorden, C., Does resection of the medial temporal lobe improve the outcome of temporal lobe epilepsy surgery? (2007) Epilepsia, 48, pp. 571-578
dc.descriptionChoi, J.Y., Kim, S.J., Hong, S.B., Extratemporal hypometabolism on FDG PET in temporal lobe epilepsy as a predictor of seizure outcome after temporal lobectomy (2003) Eur. J. Nucl. Med. Mol. Imaging, 30, pp. 581-587
dc.descriptionWong, C.H., Bleasel, A., Wen, L., The topography and significance of extratemporal hypometabolism in refractory mesial temporal lobe epilepsy examined by FDG-PET (2010) Epilepsia, 51, pp. 1365-1373
dc.descriptionVinton, A.B., Carne, R., Hicks, R.J., The extent of resection of FDG-PET hypometabolism relates to outcome of temporal lobectomy (2007) Brain, 130, pp. 548-560
dc.descriptionDiehl, B., LaPresto, E., Najm, I., Neocortical temporal FDG-PET hypometabolism correlates with temporal lobe atrophy in hippocampal sclerosis associated with microscopic cortical dysplasia (2003) Epilepsia, 44, pp. 559-564
dc.descriptionHo, S., Newton, M.R., McIntosh, A.M., Perfusion patterns during temporal lobe seizures: Relationship to surgical outcome (1997) Brain, 120, pp. 1921-1928
dc.descriptionGross, D.W., Concha, L., Beaulieu, C., Extratemporal white matter abnormalities in mesial temporal lobe epilepsy demonstrated with diffusion tensor imaging (2006) Epilepsia, 47, pp. 1360-1363
dc.descriptionDe Lanerolle, N.C., Kim, J.H., Williamson, A., A retrospective analysis of hippocampal pathology in human temporal lobe epilepsy: Evidence for distinctive patient subcategories (2003) Epilepsia, 44, pp. 677-687
dc.descriptionBlümcke, I., Pauli, E., Clusmann, H., A new clinico-pathological classification system for mesial temporal sclerosis (2007) Acta Neuropathol, 113, pp. 235-244
dc.descriptionThom, M., Mathern, G.W., Cross, J.H., Bertram, E.H., Mesial temporal lobe epilepsy: How do we improve surgical outcome? (2010) Ann. Neurol, 68, pp. 424-434
dc.descriptionBlümcke, I., Thom, M., Aronica, E., The clinicopathologic spectrum of focal cortical dysplasias: A consensus classification proposed by an ad hoc task force of the ILAE Diagnostic Methods Commission (2011) Epilepsia, 52, pp. 158-174
dc.descriptionEngel Jr., J., Surgery for seizures (1996) N. Engl. J. Med, 334, pp. 647-652
dc.descriptionSylaja, P.N., Radhakrishnan, K., Kesavadas, C., Sarma, P.S., Seizure outcome after anterior temporal lobectomy and its predictors in patients with apparent temporal lobe epilepsy and normal MRI (2004) Epilepsia, 45, pp. 803-808
dc.descriptionPacia, S.V., Ebersole, J.S., Intracranial EEG substrates of scalp ictal patterns from temporal lobe foci (1997) Epilepsia, 38, pp. 642-654
dc.descriptionCarne, R.P., O'Brien, T.J., Kilpatrick, C.J., MRI-negative PET-positive temporal lobe epilepsy: A distinct surgically remediable syndrome (2004) Brain, 127, pp. 2276-2285
dc.descriptionImmonen, A., Jutila, L., Muraja-Murro, A., Long-term epilepsy surgery outcomes in patients with MRI-negative temporal lobe epilepsy (2010) Epilepsia, 51, pp. 2260-2269
dc.descriptionVinton, A.B., Carne, R., Hicks, R.J., The extent of resection of FDG-PET hypometabolism relates to outcome of temporal lobectomy (2007) Brain, 130, pp. 548-560
dc.languageen
dc.publisher
dc.relationExpert Review of Neurotherapeutics
dc.rightsfechado
dc.sourceScopus
dc.titleUnderstanding The Spectrum Of Temporal Lobe Epilepsy: Contributions For The Development Of Individualized Therapies
dc.typeArtículos de revistas


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