Amazonian Plant Natural Products: Perspectives For Discovery Of New Antimalarial Drug Leads

dc.creatorPohlit A.M.
dc.creatorLima R.B.S.
dc.creatorFrausin G.
dc.creatorRocha E Silva L.F.
dc.creatorLopes S.C.P.
dc.creatorMoraes C.B.
dc.creatorCravo P.
dc.creatorLacerda M.V.G.
dc.creatorSiqueira A.M.
dc.creatorFreitas Jr. L.H.
dc.creatorCosta F.T.M.
dc.date2013
dc.date2015-06-25T19:18:51Z
dc.date2015-11-26T15:17:09Z
dc.date2015-06-25T19:18:51Z
dc.date2015-11-26T15:17:09Z
dc.date.accessioned2018-03-28T22:26:53Z
dc.date.available2018-03-28T22:26:53Z
dc.identifier
dc.identifierMolecules. , v. 18, n. 8, p. 9219 - 9240, 2013.
dc.identifier14203049
dc.identifier10.3390/molecules18089219
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84883188878&partnerID=40&md5=b437799ed8f9ef245dbfe55d2bc93a28
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/89853
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/89853
dc.identifier2-s2.0-84883188878
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1259391
dc.descriptionPlasmodium falciparum and P. vivax malaria parasites are now resistant, or showing signs of resistance, to most drugs used in therapy. Novel chemical entities that exhibit new mechanisms of antiplasmodial action are needed. New antimalarials that block transmission of Plasmodium spp. from humans to Anopheles mosquito vectors are key to malaria eradication efforts. Although P. vivax causes a considerable number of malaria cases, its importance has for long been neglected. Vivax malaria can cause severe manifestations and death; hence there is a need for P. vivax-directed research. Plants used in traditional medicine, namely Artemisia annua and Cinchona spp. are the sources of the antimalarial natural products artemisinin and quinine, respectively. Based on these compounds, semi-synthetic artemisinin-derivatives and synthetic quinoline antimalarials have been developed and are the most important drugs in the current therapeutic arsenal for combating malaria. In the Amazon region, where P. vivax predominates, there is a local tradition of using plant-derived preparations to treat malaria. Here, we review the current P. falciparum and P. vivax drug-sensitivity assays, focusing on challenges and perspectives of drug discovery for P. vivax, including tests against hypnozoites. We also present the latest findings of our group and others on the antiplasmodial and antimalarial chemical components from Amazonian plants that may be potential drug leads against malaria. © 2013 by the authors; licensee MDPI, Basel, Switzerland.
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dc.languageen
dc.publisher
dc.relationMolecules
dc.rightsaberto
dc.sourceScopus
dc.titleAmazonian Plant Natural Products: Perspectives For Discovery Of New Antimalarial Drug Leads
dc.typeArtículos de revistas


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