dc.creator | Barcellos K.S.A. | |
dc.creator | Bigarella C.L. | |
dc.creator | Wagner M.V. | |
dc.creator | Vieira K.P. | |
dc.creator | Lazarini M. | |
dc.creator | Langford P.R. | |
dc.creator | MacHado-Neto J.A. | |
dc.creator | Call S.G. | |
dc.creator | Staley D.M. | |
dc.creator | Chung J.Y. | |
dc.creator | Hansen M.D. | |
dc.creator | Saad S.T.O. | |
dc.date | 2013 | |
dc.date | 2015-06-25T19:18:29Z | |
dc.date | 2015-11-26T15:16:30Z | |
dc.date | 2015-06-25T19:18:29Z | |
dc.date | 2015-11-26T15:16:30Z | |
dc.date.accessioned | 2018-03-28T22:26:21Z | |
dc.date.available | 2018-03-28T22:26:21Z | |
dc.identifier | | |
dc.identifier | Journal Of Biological Chemistry. , v. 288, n. 4, p. 2179 - 2189, 2013. | |
dc.identifier | 219258 | |
dc.identifier | 10.1074/jbc.M112.432716 | |
dc.identifier | http://www.scopus.com/inward/record.url?eid=2-s2.0-84873859431&partnerID=40&md5=631c6cd82abc25675e5a2e2dc9079484 | |
dc.identifier | http://www.repositorio.unicamp.br/handle/REPOSIP/89751 | |
dc.identifier | http://repositorio.unicamp.br/jspui/handle/REPOSIP/89751 | |
dc.identifier | 2-s2.0-84873859431 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1259268 | |
dc.description | Cell-cell adhesions and the cytoskeletons play important and coordinated roles in cell biology, including cell differentiation, development, and migration. Adhesion and cytoskeletal dynamics are regulated by Rho-GTPases. ARHGAP21 is a negative regulator of Rho-GTPases, particularly Cdc42. Here we assess the function ofARHGAP21in cell-cell adhesion, cell migration, and scattering. We find that ARHGAP21 is localized in the nucleus, cytoplasm, or perinuclear region but is transiently redistributed to cell-cell junctions 4 h after initiation of cell-cell adhesion. ARHGAP21 interacts with Cdc42, and decreased Cdc42 activity coincides with the appearance of ARHGAP21 at the cell-cell junctions. Cells lacking ARHGAP21 expression show weaker cell-cell adhesions, increased cell migration, and a diminished ability to undergo hepatocyte growth factor-induced epithelialmesenchymal transition (EMT). In addition, ARHGAP21 interacts with α-tubulin, and it is essential for α-tubulin acetylation in EMT. Our findings indicate that ARHGAP21 is a Rho-GAP involved in cell-cell junction remodeling and that ARHGAP21 affects migration and EMT through α-tubulin interaction and acetylation. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc. | |
dc.description | 288 | |
dc.description | 4 | |
dc.description | 2179 | |
dc.description | 2189 | |
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dc.language | en | |
dc.publisher | | |
dc.relation | Journal of Biological Chemistry | |
dc.rights | fechado | |
dc.source | Scopus | |
dc.title | Arhgap21 Protein, A New Partner Of α-tubulin Involved In Cell-cell Adhesion Formation And Essential For Epithelial-mesenchymal Transition | |
dc.type | Artículos de revistas | |