Nano-liquid Chromatography In Pharmaceutical And Biomedical Research

dc.creatorGama M.R.
dc.creatorCollins C.H.
dc.creatorBottoli C.B.G.
dc.date2013
dc.date2015-06-25T19:18:43Z
dc.date2015-11-26T15:16:21Z
dc.date2015-06-25T19:18:43Z
dc.date2015-11-26T15:16:21Z
dc.date.accessioned2018-03-28T22:26:11Z
dc.date.available2018-03-28T22:26:11Z
dc.identifier
dc.identifierJournal Of Chromatographic Science. , v. 51, n. 7, p. 694 - 703, 2013.
dc.identifier219665
dc.identifier10.1093/chromsci/bmt023
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84880348836&partnerID=40&md5=a48abd5ab8b48efacd388c7da3d70197
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/89806
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/89806
dc.identifier2-s2.0-84880348836
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1259234
dc.descriptionMiniaturized separation techniques have emerged as environmentally friendly alternatives to available separation methods. Nano-liquid chromatography (nano-LC), microchip devices and nano-capillary electrophoresis are miniaturized methods that minimize reagent consumption and waste generation. Furthermore, the low levels of analytes, especially in biological samples, promote the search for more highly sensitive techniques; coupled to mass spectrometry, nano-LC has great potential to become an indispensable tool for routine analysis of biomolecules. This short review presents the fundamental aspects of nano-LC analytical instrumentation, discussing practical considerations and the primary differences between miniaturized and conventional instrumentation. Some theoretical aspects are discussed to better explain both the potential and the principal limitations of nano-LC. Recent pharmaceutical and biomedical applications of this separation technique are also presented to indicate the satisfactory performance for complex matrices, especially for proteomic analysis, that is obtained with nano-LC. © [2013] The Author.
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dc.languageen
dc.publisher
dc.relationJournal of Chromatographic Science
dc.rightsfechado
dc.sourceScopus
dc.titleNano-liquid Chromatography In Pharmaceutical And Biomedical Research
dc.typeArtículos de revistas


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