Characterization Of Cumulative Joint Damage Patterns In Patients With Rheumatoid Arthritis: A Clinical, Serological, And Gene Polymorphism Perspective

dc.creatorAlarcon R.T.
dc.creatorFernandes A.D.R.C.
dc.creatorLaurindo I.M.
dc.creatorBertolo M.B.
dc.creatorPinheiro G.C.
dc.creatorAndrade L.E.
dc.date2015
dc.date2015-06-25T12:54:19Z
dc.date2015-11-26T15:16:01Z
dc.date2015-06-25T12:54:19Z
dc.date2015-11-26T15:16:01Z
dc.date.accessioned2018-03-28T22:25:53Z
dc.date.available2018-03-28T22:25:53Z
dc.identifier
dc.identifierJournal Of Rheumatology. Journal Of Rheumatology, v. 42, n. 3, p. 405 - 412, 2015.
dc.identifier0315162X
dc.identifier10.3899/jrheum.131177
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84923862780&partnerID=40&md5=48ab6776f36ffd43aa4a52f2be89c488
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/85578
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/85578
dc.identifier2-s2.0-84923862780
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1259164
dc.descriptionObjective. To characterize cumulative joint damage (CJD) patterns in rheumatoid arthritis (RA) and determine their associations with demographic/clinical features and HLA-DRB1 gene polymorphism. Methods. Hand and foot radiographs were obtained from 404 patients with RA. CJD patterns were determined by 3 derivations from Sharp/van der Heijde scores, obtained by the mathematical division of scores for hands/feet (Sharp-h/f score), fingers/wrists (Sharp-f/w score), and erosion/space narrowing (Sharp-e/sn score), respectively. DNA and serum were obtained for determination of HLA-DRB1 polymorphism, rheumatoid factor (RF), and anticitrullinated protein antibodies (ACPA). Results. Patients with wrist-dominant CJD pattern were more likely to have severe RA than those with finger-dominant pattern (68.4% vs 46.0%; p = 0.036) as were those with foot-dominant vs hand-dominant CJD pattern (76.5% vs 56.4%; p = 0.044). HLA-DRB1 shared epitope (SE) alleles were associated with erosion-dominant CJD pattern (p = 0.021). Patients with erosion-dominant CJD pattern had higher levels of RF and ACPA than those with space-narrowing-dominant CJD pattern (median RF 71.35 U/ml vs 22.05 U/ml, respectively; p = 0.003; median ACPA 187.9 U/ml vs 143.2 U/ml, respectively; p < 0.001). The majority of triple-positive patients (SE+, RF+, ACPA+) had erosion-dominant CJD pattern (62.3%) while the majority of triple-negative patients (SE-, FR-, ACPA-) had space narrowing-dominant CJD pattern (75%; p = 0.017). ACPA was associated with HLA-DRB1 SE alleles (p < 0.05). Patients with foot-dominant CJD pattern were taller than those with hand-dominant CJD pattern (p = 0.002); those with erosion-dominant CJD pattern had higher weight and body mass index than those with space narrowing-dominant CJD pattern (p = 0.014, p = 0.001). Conclusion. CJD patterns were associated with disease severity, HLA-DRB1 SE status, presence and titer of ACPA and RF, and morphometric features.
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dc.languageen
dc.publisherJournal of Rheumatology
dc.relationJournal of Rheumatology
dc.rightsfechado
dc.sourceScopus
dc.titleCharacterization Of Cumulative Joint Damage Patterns In Patients With Rheumatoid Arthritis: A Clinical, Serological, And Gene Polymorphism Perspective
dc.typeArtículos de revistas


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