Characterization Of Semi-solid Self-emulsifying Drug Delivery Systems (sedds) Of Atorvastatin Calcium By Raman Image Spectroscopy And Chemometrics

dc.creatorBreitkreitz M.C.
dc.creatorSabin G.P.
dc.creatorPolla G.
dc.creatorPoppi R.J.
dc.date2013
dc.date2015-06-25T19:17:22Z
dc.date2015-11-26T15:15:18Z
dc.date2015-06-25T19:17:22Z
dc.date2015-11-26T15:15:18Z
dc.date.accessioned2018-03-28T22:25:07Z
dc.date.available2018-03-28T22:25:07Z
dc.identifier
dc.identifierJournal Of Pharmaceutical And Biomedical Analysis. , v. 73, n. , p. 3 - 12, 2013.
dc.identifier7317085
dc.identifier10.1016/j.jpba.2012.03.054
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84869497263&partnerID=40&md5=c2eab10019bf36528f22759860de36e9
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/89543
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/89543
dc.identifier2-s2.0-84869497263
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1258983
dc.descriptionA methodology based on Raman image spectroscopy and chemometrics for homogeneity evaluation of formulations containing atorvastatin calcium in Gelucire® 44/14 is presented. In the first part of the work, formulations with high amounts of Gelucire® 44/14 (80%) and solvents of different polarities (diethylene glycol monoethyl ether, propyleneglycol, propylene glycol monocaprylate and glyceryl mono/dicaprylate/caprate) were prepared for miscibility screening evaluation by classical least squares (CLS). It was observed that Gelucire® 44/14 presented higher affinity for the lipophilic solvents glyceryl mono/dicaprylate/caprate and propylene glycol monocaprylate, whose samples were observed to be homogeneous, and lower affinity for the hydrophilic solvents diethylene glycol monoethyl ether and propyleneglycol, whose samples were heterogeneous. In the second part of the work, the ratio of glyceryl mono/dicaprylate/caprate and Gelucire® 44/14 was determined based on studies in water and allowed the selection of the proportions of these two excipients in the preconcentrate that provided supersaturation of atorvastatin upon dilution. The preconcentrate was then evaluated for homogeneity by partial least squares (PLS) and an excellent miscibility was observed in this proportion as well. Therefore, it was possible to select a formulation that presented simultaneously homogeneous preconcentrate and solubility enhancement in water by Raman image spectroscopy and chemometrics. © 2012 Elsevier B.V.
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dc.languageen
dc.publisher
dc.relationJournal of Pharmaceutical and Biomedical Analysis
dc.rightsfechado
dc.sourceScopus
dc.titleCharacterization Of Semi-solid Self-emulsifying Drug Delivery Systems (sedds) Of Atorvastatin Calcium By Raman Image Spectroscopy And Chemometrics
dc.typeArtículos de revistas


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