Advantage Of Guaraná (paullinia Cupana Mart.) Supplementation On Cadmium-induced Damages In Testis Of Adult Wistar Rats

dc.creatorLeite R.P.
dc.creatorPredes F.S.
dc.creatorMonteiro J.C.
dc.creatorFreitas K.M.
dc.creatorWada R.S.
dc.creatorDolder H.
dc.date2013
dc.date2015-06-25T19:16:02Z
dc.date2015-11-26T15:14:04Z
dc.date2015-06-25T19:16:02Z
dc.date2015-11-26T15:14:04Z
dc.date.accessioned2018-03-28T22:24:10Z
dc.date.available2018-03-28T22:24:10Z
dc.identifier
dc.identifierToxicologic Pathology. , v. 41, n. 1, p. 73 - 79, 2013.
dc.identifier1926233
dc.identifier10.1177/0192623312447541
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84871663535&partnerID=40&md5=8a83093d5df401b294aceb10b899e83d
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/89391
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/89391
dc.identifier2-s2.0-84871663535
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1258785
dc.descriptionPaullinia cupana is an Amazonian bush whose seeds have long been used in folk medicine. However, most of the therapeutic properties attributed to this plant are broad and nonspecific, although an antioxidant activity has been reported. On the other hand, cadmium is a heavy metal known for increasing free radicals, hence resulting in cellular oxidative damages. This study was designed to evaluate whether Paullinia cupana is able to reduce cadmium-induced morphological impairment in Wistar rat testis. Adult male Wistar rats 110 days old were ip injected with cadmium (1.15 mg/kg BW [body weight]) and subsequently treated with P. cupana during 56 days. Furthermore, groups receiving either P. cupana extract or cadmium are mentioned. After the treatment period, testis samples were subjected to histological and stereological analyses. Moderate to severe testicular impairments were shown by the animals exposed to cadmium. However, the animals supplemented with P. cupana after cadmium exposure showed a significant decrease in the proportion of damaged seminiferous tubules. Also, P. cupana supplementation was effective in maintaining the number of Leydig cells per testis in the animals exposed to cadmium. In conclusion, P. cupana supplementation was partially efficient in preventing cadmium from damaging the testis of adult Wistar rats. © 2013 by The Author(s).
dc.description41
dc.description1
dc.description73
dc.description79
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dc.languageen
dc.publisher
dc.relationToxicologic Pathology
dc.rightsfechado
dc.sourceScopus
dc.titleAdvantage Of Guaraná (paullinia Cupana Mart.) Supplementation On Cadmium-induced Damages In Testis Of Adult Wistar Rats
dc.typeArtículos de revistas


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