Salivary Bpifa1 (splunc1) And Bpifa2 (splunc2 A) Are Modified By Head And Neck Cancer Radiotherapy

dc.creatorGonzalez-Arriagada W.A.
dc.creatorRamos L.M.A.
dc.creatorSilva A.A.
dc.creatorVargas P.A.
dc.creatorColetta R.D.
dc.creatorBingle L.
dc.creatorLopes M.A.
dc.date2015
dc.date2015-06-25T12:54:03Z
dc.date2015-11-26T15:13:55Z
dc.date2015-06-25T12:54:03Z
dc.date2015-11-26T15:13:55Z
dc.date.accessioned2018-03-28T22:24:01Z
dc.date.available2018-03-28T22:24:01Z
dc.identifier
dc.identifierOral Surgery, Oral Medicine, Oral Pathology And Oral Radiology. Mosby Inc., v. 119, n. 1, p. 48 - 58, 2015.
dc.identifier22124403
dc.identifier10.1016/j.oooo.2014.09.026
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84915818894&partnerID=40&md5=31c30fcc9cd1c7aae141147e04665eeb
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/85548
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/85548
dc.identifier2-s2.0-84915818894
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1258754
dc.descriptionMaterials and Methods Unstimulated whole-mouth saliva was collected from 45 cancer patients (1 week before treatment, during the treatment, and 1 week after completion of radiotherapy) and from 20 controls. BPIFA1 and BPIFA2 expression was detected by western blotting and analyzed along with clinicopathologic data and side effects from the radiotherapy.Results A facial radiation field was associated with lower salivary flow during and after radiotherapy and correlated with side effects, mainly mucositis. Salivary BPIFA1 expression levels were similar between the control group and the patient group before treatment. On the other hand, BPIFA2 levels were higher in the patient group before treatment compared with the control group. BPIFA concentration was modified by radiotherapy as BPIFA1 levels increased (P =.0081) and BPIFA2 decreased (P <.0001). Higher levels of BPIFA1 were associated with the presence of mucositis (P =.0363) and its severity (P =.0500).Conclusions The present study found that levels of BPIFA1 and glycosylated forms of BPIFA2 are affected by radiotherapy, suggesting that these proteins may play a role in the oral microenvironment in irradiated patients with head and neck cancer.Objective To determine the effects of radiotherapy on salivary BPIFA expression and to investigate the role of BPIFA in the development of known radiotherapy side effects.
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dc.description58
dc.descriptionSiegel, R., Ma, J., Zou, Z., Jemal, A., Cancer statistics, 2014 (2014) CA Cancer J Clin, 64, pp. 9-29
dc.descriptionBhide, S.A., Newbold, K.L., Harrington, K.J., Nutting, C.M., Clinical evaluation of intensity-modulated radiotherapy for head and neck cancers (2012) Br J Radiol, 85, pp. 487-494
dc.descriptionBourhis, J., Etessami, A., Lusinchi, A., New trends in radiotherapy for head and neck cancer (2005) Ann Oncol, 16, pp. 255-ii257
dc.descriptionSpecht, L., Oral complications in the head and neck radiation patient. Introduction and scope of the problem (2002) Support Care Cancer, 10, pp. 36-39
dc.descriptionVissink, A., Jansma, J., Spijkervet, F.K., Burlage, F.R., Coppes, R.P., Oral sequelae of head and neck radiotherapy (2003) CritRev Oral Biol Med, 14, pp. 199-212
dc.descriptionSciubba, J.J., Goldenberg, D., Oral complications of radiotherapy (2006) Lancet Oncol, 7, pp. 175-183
dc.descriptionGonzález Arriagada, W.A., Santos-Silva, A.R., Carvalho De Andrade, M.A., Elias, R.A., Lopes, M.A., Pre-radiotherapy dental evaluation criteria and treatment needs of oral side effects after head and neck radiotherapy (in Spanish) (2010) Int J Odontostomatol, 4, pp. 255-266
dc.descriptionOhrn, K.E., Sjoden, P.O., Wahlin, Y.B., Elf, M., Oral health and quality of life among patients with head and neck cancer or haematological malignancies (2001) Support Care Cancer, 9, pp. 528-538
dc.descriptionJham, B.C., Reis, P.M., Miranda, E.L., Oral health status of 207 head and neck cancer patients before, during and after radiotherapy (2008) Clin Oral Invest, 12, pp. 19-24
dc.descriptionVuotila, T., Ylikontiola, L., Sorsa, T., The relationship between MMPs and pH in whole saliva of radiated head and neck cancer patients (2002) J Oral Pathol Med, 31, pp. 329-338
dc.descriptionGrotz, K.A., Genitsariotis, S., Vehling, D., Al-Nawas, B., Long-term oral Candida colonization, mucositis and salivary function after head and neck radiotherapy (2003) Support Care Cancer, 11, pp. 717-721
dc.descriptionWeston, W.M., Leclair, E.E., Trzyna, W., Differential display identification of plunc, a novel gene expressed in embryonic palate, nasal epithelium, and adult lung (1999) J Biol Chem, 274, pp. 13698-13703
dc.descriptionBingle, C.D., Bingle, L., Characterisation of the human plunc gene, a gene product with an upper airways and nasopharyngeal restricted expression pattern (2000) Biochimica et Biophysica Acta, 1493, pp. 36336-36337
dc.descriptionBingle, L., Barnes, F.A., Lunn, H., Characterisation and expression of SPLUNC2, the human orthologue of rodent parotid secretory protein (2009) Histochem Cell Biol, 132, pp. 339-349
dc.descriptionBingle, C.D., Gorr, S.U., Host defense in oral and airway epithelia: Chromosome 20 contributes a new protein family (2004) Int J Biochem Cell Biol, 36, pp. 2144-2152
dc.descriptionBingle, C.D., Craven, C.J., PLUNC: A novel family of candidate host defence proteins expressed in the upper airways and nasopharynx (2002) Hum Mol Genet, 11, pp. 937-943
dc.descriptionBingle, C.D., Craven, C.J., Meet the relatives: A family of BPI- and LBP-related proteins (2004) Trends Immunol, 25, pp. 53-55
dc.descriptionBingle, L., Bingle, C.D., Distribution of human PLUNC/BPI fold-containing (BPIF) proteins (2011) Biochem Soc Trans, 39, pp. 1023-1027
dc.descriptionBingle, C.D., Seal, R.L., Craven, C.J., Systematic nomenclature for the PLUNC/PSP/BSP30/SMGB proteins as a subfamily of the BPI fold-containing superfamily (2011) Biochem Soc Trans, 39, pp. 977-983
dc.descriptionKohlgraf, K.G., Ackermann, A.R., Burnell, K.K., Quantitation of SPLUNC1 in saliva with an xMAP particle-based antibody capture and detection immunoassay (2012) Arch Oral Biol, 57, pp. 197-204
dc.descriptionVitorino, R., Lobo, M.J., Ferrer-Correira, A.J., Identification of human whole saliva protein components using proteomics (2004) Proteomics, 4, pp. 1109-1115
dc.descriptionDa Silva, A.A., Bingle, L., Speight, P.M., PLUNC protein expression in major salivary glands of HIV-infected patients (2011) Oral Dis, 17, pp. 258-264
dc.descriptionVargas, P.A., Speight, P.M., Bingle, C.D., Barrett, A.W., Bingle, L., Expression of PLUNC family members in benign and malignant salivary gland tumours (2008) Oral Dis, 14, pp. 613-619
dc.descriptionGonzalez-Arriagada, W.A., Santos-Silva, A.R., Ito, F.A., Expression pattern of PLUNC proteins as an auxiliary tool for the diagnosis of high-grade mucoepidermoid carcinoma of the salivary gland (2012) J Oral Pathol Med, 41, pp. 589-597
dc.descriptionBingle, L., Cross, S.S., High, A.S., SPLUNC1 (PLUNC) is expressed in glandular tissues of the respiratory tract and in lung tumours with a glandular phenotype (2005) J Pathol, 205, pp. 491-497
dc.descriptionCheng, M., Chen, Y., Yu, X., Tian, Z., Wei, H., Diagnostic utility of LunX mRNA in peripheral blood and pleural fluid in patients with primary non-small cell lung cancer (2008) BMC Cancer, 8, p. 156
dc.descriptionIwao, K., Watanabe, T., Fujiwara, Y., Isolation of a novel human lung-specific gene, LUNX, a potential molecular marker for detection of micrometastasis in non-small-cell lung cancer (2001) Int J Cancer, 91, pp. 433-437
dc.descriptionHe, Y., Zhou, G., Zhai, Y., Association of PLUNC gene polymorphisms with susceptibility to nasopharyngeal carcinoma in a Chinese population (2005) J Med Genet, 42, pp. 172-176
dc.descriptionSentani, K., Oue, N., Sakamoto, N., Gene expression profiling with microarray and SAGE identifies PLUNC as a marker for hepatoid adenocarcinoma of the stomach (2008) Mod Pathol, 21, pp. 464-475
dc.descriptionZhang, B., Nie, X., Xiao, B., Identification of tissue-specific genes in nasopharyngeal epithelial tissue and differentially expressed genes in nasopharyngeal carcinoma by suppression subtractive hybridization and cDNA microarray (2003) Genes Chromosomes Cancer, 38, pp. 80-90
dc.descriptionChu, H.W., Thaikoottathil, J., Rino, J.G., Function and regulation of SPLUNC1 protein in Mycoplasma infection and allergic inflammation (2007) J Immunol, 179, pp. 3995-4002
dc.descriptionLeclair, E.E., Four BPI (bactericidal/permeability-increasing protein)-like genes expressed in the mouse nasal, oral, airway and digestive epithelia (2003) Biochem Soc Trans, 31, pp. 801-805
dc.descriptionFabian, T.K., Hermann, P., Beck, A., Fejerdy, P., Fabian, G., Salivary defense proteins: Their network and role in innate and acquired oral immunity (2012) Int J Mol Sci, 13, pp. 4295-4320
dc.descriptionCitrin, D.E., Hitchcock, Y.J., Chung, E.J., Determination of cytokine protein levels in oral secretions in patients undergoing radiotherapy for head and neck malignancies (2012) Radiat Oncol, 7, p. 64
dc.descriptionTiwari, M., Science behind human saliva (2011) J Nat Sci Biol Med, 2, pp. 53-58
dc.descriptionTrotti, A., Bellm, L.A., Epstein, J.B., Mucositis incidence, severity and associated outcomes in patients with head and neck cancer receiving radiotherapy with or without chemotherapy: A systematic literature review (2003) Radiother Oncol, 66, pp. 253-262
dc.descriptionSharma, A., Rath, G.K., Chaudhary, S.P., Thakar, A., Mohanti, B.K., Bahadur, S., Lactobacillus brevis CD2 lozenges reduce radiation- and chemotherapy-induced mucositis in patients with head and neck cancer: A randomized double-blind placebo-controlled study (2012) Eur J Cancer, 48, pp. 875-881
dc.descriptionJellema, A.P., Slotman, B.J., Doornaert, P., Leemans, C.R., Langendijk, J.A., Impact of radiation-induced xerostomia on quality of life after primary radiotherapy among patients with head and neck cancer (2007) Int J Radiat Oncol Biol Phys, 69, pp. 751-760
dc.descriptionHopcraft, M.S., Tan, C., Xerostomia: An update for clinicians (2010) Aust Dent J, 55, pp. 238-244. , quiz 353
dc.descriptionLal, P., Bajpai, R., Khurana, R., Changes in salivary flow rates in head and neck cancer after chemoradiotherapy (2010) J Cancer Res Ther, 6, pp. 458-462
dc.descriptionKarbach, J., Walter, C., Al-Nawas, B., Evaluation of saliva flow rates, Candida colonization and susceptibility of Candida strains after head and neck radiation (2012) Clin Oral Invest, 16, pp. 1305-1312
dc.descriptionTiwana, M.S., Mahajan, M.K., Uppal, B., Whole saliva physico-biochemical changes and quality of life in head and neck cancer patients following conventional radiation therapy: A prospective longitudinal study (2011) Ind J Cancer, 48, pp. 289-295
dc.descriptionAlmstahl, A., Wikstrom, M., Electrolytes in stimulated whole saliva in individuals with hyposalivation of different origins (2003) Arch Oral Biol, 48, pp. 337-344
dc.descriptionSonis, S.T., Mucositis as a biological process: A new hypothesis for the development of chemotherapy-induced stomatotoxicity (1998) Oral Oncol, 34, pp. 39-43
dc.descriptionSonis, S.T., Mucositis: The impact, biology and therapeutic opportunities of oral mucositis (2009) Oral Oncol, 45, pp. 1015-1020
dc.descriptionGaetti-Jardim, E.J., Ciesielski, F.I., De Sousa, F.R., Nwaokorie, F., Schweitzer, C.M., Avila-Campos, M.J., Occurrence of yeasts, pseudomonads and enteric bacteria in the oral cavity of patients undergoing head and neck radiotherapy (2011) Braz J Microbiol, 42, pp. 1047-1055
dc.descriptionWijers, O.B., Levendag, P.C., Harms, E.R., Mucositis reduction by selective elimination of oral flora in irradiated cancers of the head and neck: A placebo-controlled double-blind randomized study (2001) Int J Radiat Oncol Biol Phys, 50, pp. 343-352
dc.descriptionStokman, M.A., Spijkervet, F.K., Burlage, F.R., Oral mucositis and selective elimination of oral flora in head and neck cancer patients receiving radiotherapy: A double-blind randomised clinical trial (2003) Br J Cancer, 88, pp. 1012-1016
dc.descriptionEl-Sayed, S., Nabid, A., Shelley, W., Prophylaxis of radiation-associated mucositis in conventionally treated patients with head and neck cancer: A double-blind, phase III, randomized, controlled trial evaluating the clinical efficacy of an antimicrobial lozenge using a validated mucositis scoring system (2002) J Clin Oncol, 20, pp. 3956-3963
dc.descriptionSeshadri, S., Lin, D.C., Rosati, M., Reduced expression of antimicrobial PLUNC proteins in nasal polyp tissues of patients with chronic rhinosinusitis (2012) Allergy, 67, pp. 920-928
dc.descriptionSoysa, N.S., Samaranayake, L.P., Ellepola, A.N., Cytotoxic drugs, radiotherapy and oral candidiasis (2004) Oral Oncol, 40, pp. 971-978
dc.descriptionDijkema, T., Terhaard, C.H., Roesink, J.M., MUC5 B levels in submandibular gland saliva of patients treated with radiotherapy for head-and-neck cancer: A pilot study (2012) Radiat Oncol, 7, p. 91
dc.descriptionMitas, M., Hoover, L., Silvestri, G., Lunx is a superior molecular marker for detection of non-small cell lung cancer in peripheral blood [corrected] (2003) J Mol Diagnostics, 5, pp. 237-242
dc.descriptionLemaire, F., Millon, R., Young, J., Differential expression profiling of head and neck squamous cell carcinoma (HNSCC) (2003) Br J Cancer, 89, pp. 1940-1949
dc.descriptionGhafouri, B., Stahlbom, B., Tagesson, C., Lindahl, M., Newly identified proteins in human nasal lavage fluid from non-smokers and smokers using two-dimensional gel electrophoresis and peptide mass fingerprinting (2002) Proteomics, 2, pp. 112-120
dc.descriptionNaidu, M.U., Ramana, G.V., Rani, P.U., Mohan, I.K., Suman, A., Roy, P., Chemotherapy-induced and/or radiation therapy-induced oral mucositis - Complicating the treatment of cancer (2004) Neoplasia, 6, pp. 423-431
dc.descriptionSonis, S.T., Lindquist, L., Van Vugt, A., Prevention of chemotherapy-induced ulcerative mucositis by transforming growth factor beta 3 (1994) Cancer Res, 54, pp. 1135-1138
dc.descriptionHelmerhorst, E.J., Oppenheim, F.G., Saliva: A dynamic proteome (2007) J Dent Res, 86, pp. 680-693
dc.descriptionBingle, C.D., Leclair, E.E., Havard, S., Bingle, L., Gillingham, P., Craven, C.J., Phylogenetic and evolutionary analysis of the PLUNC gene family (2004) Protein Sci, 13, pp. 422-430
dc.descriptionWheeler, T.T., Haigh, B.J., McCracken, J.Y., Wilkins, R.J., Morris, C.A., Grigor, M.R., The BSP30 salivary proteins from cattle, LUNX/PLUNC and von Ebner's minor salivary gland protein are members of the PSP/LBP superfamily of proteins (2002) Biochim Biophys Acta, 1579, pp. 92-100
dc.descriptionWheeler, T.T., Hood, K.A., Maqbool, N.J., McEwan, J.C., Bingle, C.D., Zhao, S., Expansion of the Bactericidal/Permeability Increasing-like (BPI-like) protein locus in cattle (2007) BMC Genomics, 8, p. 75
dc.descriptionRobinson, C.P., Bounous, D.I., Alford, C.E., PSP expression in murine lacrimal glands and function as a bacteria binding protein in exocrine secretions (1997) Am J Physiol, 272, pp. 863-G871
dc.descriptionGeetha, C., Venkatesh, S.G., Dunn, B.H., Gorr, S.U., Expression and anti-bacterial activity of human parotid secretory protein (PSP) (2003) Biochem Soc Trans, 31, pp. 815-818
dc.descriptionGorr, S.U., Sotsky, J.B., Shelar, A.P., Demuth, D.R., Design of bacteria-agglutinating peptides derived from parotid secretory protein, a member of the bactericidal/permeability increasing-like protein family (2008) Peptides, 29, pp. 2118-2127
dc.descriptionHaigh, B., Hood, K., Broadhurst, M., The bovine salivary proteins BSP30 a and BSP30 b are independently expressed BPI-like proteins with anti-Pseudomonas activity (2008) Mol Immunol, 45, pp. 1944-1951
dc.descriptionKhovidhunkit, W., Hachem, J.P., Medzihradszky, K.F., Parotid secretory protein is an HDL-associated protein with anticandidal activity (2005) Am J Physiol Regulat Integrat Comparat Physiol, 288, pp. 1306-R1315
dc.descriptionGeetha, C., Venkatesh, S.G., Bingle, L., Bingle, C.D., Gorr, S.U., Design and validation of anti-inflammatory peptides from human parotid secretory protein (2005) J Dent Res, 84, pp. 149-153
dc.descriptionEpstein, J.B., Chin, E.A., Jacobson, J.J., Rishiraj, B., Le, N., The relationships among fluoride, cariogenic oral flora, and salivary flow rate during radiation therapy (1998) Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 86, pp. 286-292
dc.descriptionEpstein, J.B., Van Der Meij, E.H., Lunn, R., Stevenson-Moore, P., Effects of compliance with fluoride gel application on caries and caries risk in patients after radiation therapy for head and neck cancer (1996) Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 82, pp. 268-275
dc.descriptionTsou, Y.A., Peng, M.T., Wu, Y.F., Decreased PLUNC expression in nasal polyps is associated with multibacterial colonization in chronic rhinosinusitis patients (2014) Eur Arch Otorhinolaryngol, 271, pp. 299-304
dc.languageen
dc.publisherMosby Inc.
dc.relationOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
dc.rightsfechado
dc.sourceScopus
dc.titleSalivary Bpifa1 (splunc1) And Bpifa2 (splunc2 A) Are Modified By Head And Neck Cancer Radiotherapy
dc.typeArtículos de revistas


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