Epa Protects Against Muscle Damage In The Mdx Mouse Model Of Duchenne Muscular Dystrophy By Promoting A Shift From The M1 To M2 Macrophage Phenotype

dc.creatorde Carvalho S.C.
dc.creatorApolinario L.M.
dc.creatorMatheus S.M.M.
dc.creatorSanto Neto H.
dc.creatorMarques M.J.
dc.date2013
dc.date2015-06-25T19:15:58Z
dc.date2015-11-26T15:13:54Z
dc.date2015-06-25T19:15:58Z
dc.date2015-11-26T15:13:54Z
dc.date.accessioned2018-03-28T22:24:00Z
dc.date.available2018-03-28T22:24:00Z
dc.identifier
dc.identifierJournal Of Neuroimmunology. , v. 264, n. 1/Fev, p. 41 - 47, 2013.
dc.identifier1655728
dc.identifier10.1016/j.jneuroim.2013.09.007
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84886780290&partnerID=40&md5=132da432ee453e85cb6fb307fde7ea55
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/89374
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/89374
dc.identifier2-s2.0-84886780290
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1258750
dc.descriptionIn dystrophic mdx mice and in Duchenne muscular dystrophy, inflammation contributes to myonecrosis. Previously, we demonstrated that eicosapentaenoic acid (EPA) decreased inflammation and necrosis in dystrophic muscle. In the present study, we examined the effects of EPA and the corticoid deflazacort (DFZ) as modulators of M1 (iNOS-expressing cells) and M2 (CD206-expressing cells) macrophages. Mdx mice (14. days old) received EPA or DFZ for 16. days. The diaphragm, biceps brachii and quadriceps muscles were studied. Immunofluorescence, immunoblotting and ELISA assays showed that EPA increased interleucin-10, reduced interferon-γ and was more effective than DFZ in promoting a shift from M1 to M2. © 2013 Elsevier B.V.
dc.description264
dc.description1/Fev
dc.description41
dc.description47
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dc.languageen
dc.publisher
dc.relationJournal of Neuroimmunology
dc.rightsfechado
dc.sourceScopus
dc.titleEpa Protects Against Muscle Damage In The Mdx Mouse Model Of Duchenne Muscular Dystrophy By Promoting A Shift From The M1 To M2 Macrophage Phenotype
dc.typeArtículos de revistas


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