Artículos de revistas
Il10 Inversely Correlates With The Percentage Of Cd8+ Cells In Mds Patients
Registro en:
Leukemia Research. , v. 37, n. 5, p. 541 - 546, 2013.
1452126
10.1016/j.leukres.2013.01.019
2-s2.0-84875906562
Autor
Lopes M.R.
Traina F.
Campos P.D.M.
Pereira J.K.N.
Machado-Neto J.A.
Machado H.D.C.
Gilli S.C.O.
Saad S.T.O.
Favaro P.
Institución
Resumen
The role of the immune system in myelodysplastic syndrome (MDS) progression has been widely accepted, although mechanisms underlying this immune dysfunction are not clear. CD4+ and CD8+ lymphocyte profiles in the peripheral blood of MDS patients were evaluated and correlated with clinical characteristics, the expression of FOXP3 and the anti-inflammatory cytokines IL10, TGFβ1 and CTLA4. IL10 expression inversely correlated with the percentage of CD8+ cells and was higher in high-risk MDS. Our findings provide further evidence for the role of T cell-mediated IL10 production in MDS and strengthen the idea of distinct cytokine profiles in low and high-risk MDS. © 2013 Elsevier Ltd. 37 5 541 546 Deeg, H.J., Beckham, C., Loken, M.R., Bryant, E., Lesnikova, M., Shulman, H.M., Gooley, T., Negative regulators of hemopoiesis and stroma function in patients with myelodysplastic syndrome (2000) Leuk Lymphoma, 37, pp. 405-414 Mufti, G., List, A.F., Gore, S.D., Ho, A.Y., Myelodysplastic syndrome (2003) Hematology Am Soc Hematol Educ Program, pp. 176-199 Parker, J.E., Mufti, G.J., Ineffective hematopoiesis and apoptosis in myelodysplastic syndromes (1998) Br J Haematol, 101, pp. 220-230 Parker, J.E., Mufti, G.J., Excessive apoptosis in low risk myelodysplastic syndromes (MDS) (2000) Leuk Lymphoma, 40, pp. 1-24 Parker, J.E., Mufti, G.J., Rasool, F., Mijovic, A., Devereux, S., Pagliuca, A., The role of apoptosis, proliferation, and the Bcl-2-related proteins in the myelodysplastic syndromes and acute myeloid leukemia secondary to MDS (2000) Blood, 96, pp. 3932-3938 Barrett, A.J., Sloand, E., Autoimmune mechanisms in the pathophysiology of myelodysplastic syndromes and their clinical relevance (2009) Haematologica, 94, pp. 449-451 Aggarwal, S., van de Loosdrecht, A.A., Alhan, C., Ossenkoppele, G.J., Westers, T.M., Bontkes, H.J., Role of immune responses in the pathogenesis of low-risk MDS and high-risk MDS: implications for immunotherapy (2011) Br J Haematol, 153, pp. 568-581 Kotsianidis, I., Bouchliou, I., Nakou, E., Spanoudakis, E., Margaritis, D., Christophoridou, A.V., Anastasiades, A., Tsatalas, C., Kinetics, function and bone marrow trafficking of CD4+CD25+FOXP3+ regulatory T cells in myelodysplastic syndromes (MDS) (2009) Leukemia, 23, pp. 510-518 Ortega, J., List, A., Immunomodulatory drugs in the treatment of myelodysplastic syndromes (2007) Curr Opin Oncol, 19, pp. 656-659 Greenberg, P.L., Young, N.S., Gattermann, N., Myelodysplastic syndromes (2002) Hematology Am Soc Hematol Educ Program, pp. 136-161 Molldrem, J.J., Caples, M., Mavroudis, D., Plante, M., Young, N.S., Barrett, A.J., Antithymocyte globulin for patients with myelodysplastic syndrome (1997) Br J Haematol, 99, pp. 699-705 Killick, S.B., Mufti, G., Cavenagh, J.D., Mijovic, A., Peacock, J.L., Gordon-Smith, E.C., Bowen, D.T., Marsh, J.C., A pilot study of antithymocyte globulin (ATG) in the treatment of patients with 'low-risk' myelodysplasia (2003) Br J Haematol, 120, pp. 679-684 Fozza, C., Longinotti, M., Are T-cell dysfunctions the other side of the moon in the pathogenesis of myelodysplastic syndromes? (2012) Eur J Haematol, 88, pp. 380-387 Kordasti, S.Y., Ingram, W., Hayden, J., Darling, D., Barber, L., Afzali, B., Lombardi, G., Mufti, G.J., CD4+CD25high Foxp3+ regulatory T cells in myelodysplastic syndrome (MDS) (2007) Blood, 110, pp. 847-850 Zou, J.X., Rollison, D.E., Boulware, D., Chen, D.T., Sloand, E.M., Pfannes, L.V., Goronzy, J.J., Epling-Burnette, P.K., Altered naive and memory CD4+ T-cell homeostasis and immunosenescence characterize younger patients with myelodysplastic syndrome (2009) Leukemia, 23, pp. 1288-1296 Livak, K.J., Schmittgen, T.D., Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method (2001) Methods, 25, pp. 402-408 Tabachnick, B.G., Fidell, L.S., (2001) Using Multivariate Statistics, pp. 111-176. , Allyn and Bacon, Boston Yoshida, Y., Stephenson, J., Mufti, G.J., Myelodysplastic syndromes: from morphology to molecular biology. Part I. Classification, natural history and cell biology of myelodysplasia (1993) Int J Hematol, 57, pp. 87-97 Bogdanovic, A.D., Trpinac, D.P., Jankovic, G.M., Bumbasirevic, V.Z., Obradovic, M., Colovic, M.D., Incidence and role of apoptosis in myelodysplastic syndrome: morphological and ultrastructural assessment (1997) Leukemia, 11, pp. 656-659 Nilsson, L., Astrand-Grundstrom, I., Arvidsson, I., Jacobsson, B., Hellstrom-Lindberg, E., Hast, R., Jacobsen, S.E., Isolation and characterization of hematopoietic progenitor/stem cells in 5q-deleted myelodysplastic syndromes: evidence for involvement at the hematopoietic stem cell level (2000) Blood, 96, pp. 2012-2021 Shioi, Y., Tamura, H., Yokose, N., Satoh, C., Dan, K., Ogata, K., Increased apoptosis of circulating T cells in myelodysplastic syndromes (2007) Leuk Res, 31, pp. 1641-1648 Nimer, S.D., MDS: a stem cell disorder - but what exactly is wrong with the primitive hematopoietic cells in this disease? (2008) Hematology Am Soc Hematol Educ Program, pp. 43-51 Bynoe, A.G., Scott, C.S., Ford, P., Roberts, B.E., Decreased T helper cells in the myelodysplastic syndromes (1983) Br J Haematol, 54, pp. 97-102 Hamblin, T.J., Immunological abnormalities in myelodysplastic syndromes (1996) Semin Hematol, 33, pp. 150-162 Hamblin, T., Immunologic abnormalities in myelodysplastic syndromes (1992) Hematol Oncol Clin North Am, 6, pp. 571-586 Amin, H.M., Jilani, I., Estey, E.H., Keating, M.J., Dey, A.L., Manshouri, T., Kantarjian, H.M., Albitar, M., Increased apoptosis in bone marrow B lymphocytes but not T lymphocytes in myelodysplastic syndrome (2003) Blood, 102, pp. 1866-1868 Chan, A.C., Neeson, P., Leeansyah, E., Tainton, K., Quach, H., Prince, H.M., Godfrey, D.I., Berzins, S.P., Testing the NKT cell hypothesis in lenalidomide-treated myelodysplastic syndrome patients (2010) Leukemia, 24, pp. 592-600 Hamada, K., Takahashi, I., Matsuoka, M., Saika, T., Mizobuchi, N., Yorimitsu, S., Takimoto, H., Apoptosis of peripheral leukocytes in patients with myelodysplastic syndromes (1998) Rinsho Ketsueki, 39, pp. 1079-1084 Matsutani, T., Yoshioka, T., Tsuruta, Y., Shimamoto, T., Ohyashiki, J.H., Suzuki, R., Ohyashiki, K., Determination of T-cell receptors of clonal CD8-positive T-cells in myelodysplastic syndrome with erythroid hypoplasia (2003) Leuk Res, 27, pp. 305-312 Epling-Burnette, P.K., Painter, J.S., Rollison, D.E., Ku, E., Vendron, D., Widen, R., Boulware, D., List, A.F., Prevalence and clinical association of clonal T-cell expansions in Myelodysplastic Syndrome (2007) Leukemia, 21, pp. 659-667 Fozza, C., Contini, S., Galleu, A., Simula, M.P., Virdis, P., Bonfigli, S., Longinotti, M., Patients with myelodysplastic syndromes display several T-cell expansions, which are mostly polyclonal in the CD4(+) subset and oligoclonal in the CD8(+) subset (2009) Exp Hematol, 37, pp. 947-955 Kook, H., Zeng, W., Guibin, C., Kirby, M., Young, N.S., Maciejewski, J.P., Increased cytotoxic T cells with effector phenotype in aplastic anemia and myelodysplasia (2001) Exp Hematol, 29, pp. 1270-1277 Sloand, E.M., Melenhorst, J.J., Tucker, Z.C., Pfannes, L., Brenchley, J.M., Yong, A., Visconte, V., Young, N.S., T-cell immune responses to Wilms tumor 1 protein in myelodysplasia responsive to immunosuppressive therapy (2011) Blood, 117, pp. 2691-2699 Maciejewski, J.P., Risitano, A., Sloand, E.M., Nunez, O., Young, N.S., Distinct clinical outcomes for cytogenetic abnormalities evolving from aplastic anemia (2002) Blood, 99, pp. 3129-3135 Sloand, E.M., Mainwaring, L., Fuhrer, M., Ramkissoon, S., Risitano, A.M., Keyvanafar, K., Lu, J., Young, N.S., Preferential suppression of trisomy 8 compared with normal hematopoietic cell growth by autologous lymphocytes in patients with trisomy 8 myelodysplastic syndrome (2005) Blood, 106, pp. 841-851 Chamuleau, M.E., Westers, T.M., van Dreunen, L., Groenland, J., Zevenbergen, A., Eeltink, C.M., Ossenkoppele, G.J., van de Loosdrecht, A.A., Immune mediated autologous cytotoxicity against hematopoietic precursor cells in patients with myelodysplastic syndrome (2009) Haematologica, 94, pp. 496-506 Meers, S., Vandenberghe, P., Boogaerts, M., Verhoef, G., Delforge, M., The clinical significance of activated lymphocytes in patients with myelodysplastic syndromes: a single centre study of 131 patients (2008) Leuk Res, 32, pp. 1026-1035 Symeonidis, A., Kourakli, A., Katevas, P., Perraki, M., Tiniakou, M., Matsouka, P., Georgoulias, V., Zoumbos, N., Immune function parameters at diagnosis in patients with myelodysplastic syndromes: correlation with the FAB classification and prognosis (1991) Eur J Haematol, 47, pp. 277-281 Hamdi, W., Ogawara, H., Handa, H., Tsukamoto, N., Murakami, H., Clinical significance of Th1/Th2 ratio in patients with myelodysplastic syndrome (2009) Int J Lab Hematol, 31, pp. 630-638 Hori, S., Nomura, T., Sakaguchi, S., Control of regulatory T cell development by the transcription factor Foxp3 (2003) Science, 299, pp. 1057-1061 Hahn, B.H., Singh, R.P., La Cava, A., Ebling, F.M., Tolerogenic treatment of lupus mice with consensus peptide induces Foxp3-expressing, apoptosis-resistant, TGFbeta-secreting CD8+ T cell suppressors (2005) J Immunol, 175, pp. 7728-7737 Wong, M., La Cava, A., Singh, R.P., Hahn, B.H., Blockade of programmed death-1 in young (New Zealand black x New Zealand white)F1 mice promotes the activity of suppressive CD8+ T cells that protect from lupus-like disease (2010) J Immunol, 185, pp. 6563-6571 Frisullo, G., Nociti, V., Iorio, R., Plantone, D., Patanella, A.K., Tonali, P.A., Batocchi, A.P., CD8(+)Foxp3(+) T cells in peripheral blood of relapsing-remitting multiple sclerosis patients (2010) Hum Immunol, 71, pp. 437-441 Tsai, Y.G., Yang, K.D., Niu, D.M., Chien, J.W., Lin, C.Y., TLR2 agonists enhance CD8+ Foxp3+ regulatory T cells and suppress Th2 immune responses during allergen immunotherapy (2010) J Immunol, 184, pp. 7229-7237 Zhou, H., Wang, Z.D., Zhu, X., You, Y., Zou, P., CD8+ FOXP3+ T cells from renal transplant recipients in quiescence induce immunoglobulin-like transcripts-3 and -4 on dendritic cells from their respective donors (2007) Transplant Proc, 39, pp. 3065-3067 Lerret, N.M., Houlihan, J.L., Kheradmand, T., Pothoven, K.L., Zhang, Z.J., Luo, X., Donor-specific CD8+ Foxp3+ T cells protect skin allografts and facilitate induction of conventional CD4+ Foxp3+ regulatory T cells (2012) Am J Transplant, 12, pp. 2335-2347 Fozza, C., Longu, F., Contini, S., Galleu, A., Virdis, P., Bonfigli, S., Murineddu, M., Longinotti, M., Patients with Early-Stage Myelodysplastic Syndromes Show Increased Frequency of CD4+CD25+CD127(low) Regulatory T Cells (2012) Acta Haematol, 128, pp. 178-182 Kordasti, S.Y., Afzali, B., Lim, Z., Ingram, W., Hayden, J., Barber, L., Matthews, K., Mufti, G.J., IL-17-producing CD4(+) T cells, pro-inflammatory cytokines and apoptosis are increased in low risk myelodysplastic syndrome (2009) Br J Haematol, 145, pp. 64-72 Alfinito, F., Sica, M., Luciano, L., Pepa, R.D., Palladino, C., Ferrara, I., Giani, U., Terrazzano, G., Immune dysregulation and dyserythropoiesis in the myelodysplastic syndromes (2009) Br J Haematol, 148, pp. 90-98 Moore, K.W., de Waal Malefyt, R., Coffman, R.L., O'Garra, A., Interleukin-10 and the interleukin-10 receptor (2001) Annu Rev Immunol, 19, pp. 683-765 Kang, S.S., Allen, P.M., Priming in the presence of IL-10 results in direct enhancement of CD8+ T cell primary responses and inhibition of secondary responses (2005) J Immunol, 174, pp. 5382-5389