| dc.creator | Andrade F.L. | |
| dc.creator | Annichino-Bizzacchi J.M. | |
| dc.creator | Saad S.T.O. | |
| dc.creator | Costa F.F. | |
| dc.creator | Arruda V.R. | |
| dc.date | 1998 | |
| dc.date | 2015-06-30T15:05:32Z | |
| dc.date | 2015-11-26T15:13:28Z | |
| dc.date | 2015-06-30T15:05:32Z | |
| dc.date | 2015-11-26T15:13:28Z | |
| dc.date.accessioned | 2018-03-28T22:23:35Z | |
| dc.date.available | 2018-03-28T22:23:35Z | |
| dc.identifier | | |
| dc.identifier | American Journal Of Hematology. , v. 59, n. 1, p. 46 - 50, 1998. | |
| dc.identifier | 3618609 | |
| dc.identifier | 10.1002/(SICI)1096-8652(199809)59:1<46::AID-AJH9>3.0.CO;2-# | |
| dc.identifier | http://www.scopus.com/inward/record.url?eid=2-s2.0-0031825212&partnerID=40&md5=b5c48463bd90a9b79bb93c3aaa8bc15e | |
| dc.identifier | http://www.repositorio.unicamp.br/handle/REPOSIP/100567 | |
| dc.identifier | http://repositorio.unicamp.br/jspui/handle/REPOSIP/100567 | |
| dc.identifier | 2-s2.0-0031825212 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1258648 | |
| dc.description | The prevalence of the prothrombin gene variant (allele 20.210 A), factor V Leiden mutation, and homozygosity for transition 677C→T in the methylenetetrahydrofolate reductase (MTHFR) gene was determined among patients with sickle cell disease (SCD). The group included 73 patients with median age of 32,3 years with a diagnosis of sickle cell anemia in 53 patients, hemoglobinopathy SC in 16 patients, and four with S/β°thalassemia. Vascular complications such as ischemic stroke or deep vein thrombosis were diagnosed in nine patients. Heterozygosity for the prothrombin gene variant or factor V Leiden mutation was identified in four patients. However, only one patient, who developed ischemic stroke, was identified as a carrier of factor V Leiden mutation. None of the patients presented homozygosity for the thermolabile variant of the MTHFR. These data suggest a low clinical impact of inherited hypercoagulability risk factors in developing thrombosis, occlusive stroke, or mortality data among patients with SCD in Brazil. | |
| dc.description | 59 | |
| dc.description | 1 | |
| dc.description | 46 | |
| dc.description | 50 | |
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| dc.language | en | |
| dc.publisher | | |
| dc.relation | American Journal of Hematology | |
| dc.rights | fechado | |
| dc.source | Scopus | |
| dc.title | Prothrombin Mutant, Factor V Leiden, And Thermolabile Variant Of Methylenetetrahidrofolate Reductase Among Patients With Sickle Cell Disease In Brazil | |
| dc.type | Artículos de revistas | |
