Bartonella Spp. Bacteremia In Blood Donors From Campinas, Brazil

dc.creatorPitassi L.H.U.
dc.creatorde Paiva Diniz P.P.V.
dc.creatorScorpio D.G.
dc.creatorDrummond M.R.
dc.creatorLania B.G.
dc.creatorBarjas-Castro M.L.
dc.creatorGilioli R.
dc.creatorColombo S.
dc.creatorSowy S.
dc.creatorBreitschwerdt E.B.
dc.creatorNicholson W.L.
dc.creatorVelho P.E.N.F.
dc.date2015
dc.date2015-06-25T12:53:55Z
dc.date2015-11-26T15:12:59Z
dc.date2015-06-25T12:53:55Z
dc.date2015-11-26T15:12:59Z
dc.date.accessioned2018-03-28T22:23:04Z
dc.date.available2018-03-28T22:23:04Z
dc.identifier
dc.identifierPlos Neglected Tropical Diseases. Public Library Of Science, v. 9, n. 1, p. - , 2015.
dc.identifier19352727
dc.identifier10.1371/journal.pntd.0003467
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84922262454&partnerID=40&md5=775f23bbbd0141c72d421f4d9cbc9298
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/85526
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/85526
dc.identifier2-s2.0-84922262454
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1258520
dc.descriptionBartonella species are blood-borne, re-emerging organisms, capable of causing prolonged infection with diverse disease manifestations, from asymptomatic bacteremia to chronic debilitating disease and death. This pathogen can survive for over a month in stored blood. However, its prevalence among blood donors is unknown, and screening of blood supplies for this pathogen is not routinely performed. We investigated Bartonella spp. prevalence in 500 blood donors from Campinas, Brazil, based on a cross-sectional design. Blood samples were inoculated into an enrichment liquid growth medium and sub-inoculated onto blood agar. Liquid culture samples and Gram-negative isolates were tested using a genus specific ITS PCR with amplicons sequenced for species identification. Bartonella henselae and Bartonella quintana antibodies were assayed by indirect immunofluorescence. B. henselae was isolated from six donors (1.2%). Sixteen donors (3.2%) were Bartonella-PCR positive after culture in liquid or on solid media, with 15 donors infected with B. henselae and one donor infected with Bartonella clarridgeiae. Antibodies against B. henselae or B. quintana were found in 16% and 32% of 500 blood donors, respectively. Serology was not associated with infection, with only three of 16 Bartonella-infected subjects seropositive for B. henselae or B. quintana. Bartonella DNA was present in the bloodstream of approximately one out of 30 donors from a major blood bank in South America. Negative serology does not rule out Bartonella spp. infection in healthy subjects. Using a combination of liquid and solid cultures, PCR, and DNA sequencing, this study documents for the first time that Bartonella spp. bacteremia occurs in asymptomatic blood donors. Our findings support further evaluation of Bartonella spp. transmission which can occur through blood transfusions.
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dc.languageen
dc.publisherPublic Library of Science
dc.relationPLoS Neglected Tropical Diseases
dc.rightsaberto
dc.sourceScopus
dc.titleBartonella Spp. Bacteremia In Blood Donors From Campinas, Brazil
dc.typeArtículos de revistas


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