Large-scale Analyses Of Schizophrenia Proteome [análise Proteômica Da Esquizofrenia]

dc.creatorOliveira B.M.
dc.creatorMartins-de-Souza D.
dc.date2013
dc.date2015-06-25T19:15:02Z
dc.date2015-11-26T15:12:38Z
dc.date2015-06-25T19:15:02Z
dc.date2015-11-26T15:12:38Z
dc.date.accessioned2018-03-28T22:22:42Z
dc.date.available2018-03-28T22:22:42Z
dc.identifier
dc.identifierRevista De Psiquiatria Clinica. , v. 40, n. 1, p. 16 - 19, 2013.
dc.identifier1016083
dc.identifier10.1590/S0101-60832012005000004
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84874386353&partnerID=40&md5=886550675425a86e06a3f93592a33a10
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/89186
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/89186
dc.identifier2-s2.0-84874386353
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1258427
dc.descriptionValuable knowledge about schizophrenia has been recently generated for deciphering its pathobiology and revealing biomarkers. However, efforts are still needed, especially if we take in account that this debilitating mental disorder affects approximately 30 million people worldwide. Considering that schizophrenia is a result of a complex interaction among environmental factors altered gene function and systematic differential protein expression, proteomics is likely to be a suitable tool for studying this disorder. Here we synthetize the main findings by proteomic studies and further directions to be taken in order to better comprehend the biochemistry of schizophrenia as well as reveal biomarkers. In addition, we summarize proteomic methodologies used in such studies.
dc.description40
dc.description1
dc.description16
dc.description19
dc.descriptionMartins-de-Souza, D., Guest, P.C., Rahmoune, H., Bahn, S., Proteomic approaches to unravel the complexity of schizophrenia (2012) Expert Rev Proteomics., 9, pp. 97-108
dc.descriptionMartins-De-Souza, D., Dias-Neto, E., Schmitt, A., Falkai, P., Gormanns, P., McCarrone, G., Proteome analysis of schizophrenia brain tissue (2010) World J Biol Psychiatry., 11, pp. 110-120
dc.descriptionMartins-de-Souza, D., Gattaz, W.F., Schmitt, A., Rewerts, C., Marangoni, S., Novello, J.C., Alterations in oligodendrocyte proteins, calcium homeostasis and new potential markers in schizophrenia anterior temporal lobe are revealed by shotgun proteome analysis (2009) J Neural Transm., 116, pp. 275-289
dc.descriptionBergson, C., Levenson, R., Goldman-Rakic, P.S., Lidow, M.S., Dopamine receptor-interacting proteins: The Ca(2+) connection in dopamine signaling (2003) Trends Pharmacol Sci., 24, pp. 486-492
dc.descriptionMartins-de-Souza, D., Proteome and transcriptome analysis suggests oligodendrocyte dysfunction in schizophrenia (2010) J Psychiatr Res., 44, pp. 149-156
dc.descriptionHakak, Y., Walker, J.R., Li, C., Wong, W.H., Davis, K.L., Buxbaum, J.D., Genome-wide expression analysis reveals dysregulation of myelinationrelated genes in chronic schizophrenia (2001) Proc Natl Acad Sci U S A., 98, pp. 4746-4751
dc.descriptionTkachev, D., Mimmack, M.L., Ryan, M.M., Wayland, M., Freeman, T., Jones, P.B., Oligodendrocyte dysfunction in schizophrenia and bipolar disorder (2003) Lancet., 362, pp. 798-805
dc.descriptionMartins-de-Souza, D., McCarrone, G., Wobrock, T., Zerr, I., Gormanns, P., Reckow, S., Proteome analysis of the thalamus and cerebrospinal fluid reveals glycolysis dysfunction and potential biomarkers candidates for schizophrenia (2010) J Psychiatr Res., 44, pp. 1176-1189
dc.descriptionHuang, J.T., Wang, L., Prabakaran, S., Wengenroth, M., Lockstone, H.E., Koethe, D., Independent protein-profiling studies show a decrease in apolipoprotein A1 levels in schizophrenia CSF, brain and peripheral tissues (2008) Mol Psychiatry., 13, pp. 1118-1128
dc.descriptionMartins-De-Souza, D., Wobrock, T., Zerr, I., Schmitt, A., Gawinecka, J., Schneider-Axmann, T., Different apolipoprotein E, apolipoprotein A1 and prostaglandin-H2 D-isomerase levels in cerebrospinal fluid of schizophrenia patients and healthy controls (2010) World J Biol Psychiatry., 11, pp. 719-728
dc.descriptionLee, Y., Morrison, B.M., Li, Y., Lengacher, S., Farah, M.H., Hoffman, P.N., Liu, Y., Oligodendroglia metabolically support axons and contribute to neurodegeneration (2012) Nature., 487, pp. 443-448
dc.descriptionJacquy, J., Wilmotte, J., Piraux, A., Noel, G., Cerebral blood flow patterns studied by rheoencephalography in schizophrenia (1976) Neuropsychobiology., 2, pp. 94-103
dc.descriptionMarek, G.J., Behl, B., Bespalov, A.Y., Gross, G., Lee, Y., Schoemaker, H., Glutamatergic (N-methyl-D-aspartate receptor) hypofrontality in schizophrenia: Too little juice or a miswired brain? (2010) Mol Pharmacol., 77, pp. 317-326
dc.descriptionTamminga, C.A., Thaker, G.K., Buchanan, R., Kirkpatrick, B., Alphs, L.D., Chase, T.N., Limbic system abnormalities identified in schizophrenia using positron emission tomography with fluorodeoxyglucose and neocortical alterations with deficit syndrome (1992) Arch Gen Psychiatry., 49, pp. 522-530
dc.descriptionMartins-de-Souza, D., Guest, P.C., Harris, L.W., Vanattou-Saifoudine, N., Webster, M.J., Rahmoune, H., Identification of proteomic signatures associated with depression and psychotic depression in post-mortem brains from major depression patients (2012) Transl Psychiatry., 2, pp. e87
dc.descriptionPrabakaran, S., Wengenroth, M., Lockstone, H.E., Lilley, K., Leweke, F.M., Bahn, S., 2-D DIGE analysis of liver and red blood cells provides further evidence for oxidative stress in schizophrenia (2007) J Proteome Res., 6, pp. 141-149
dc.descriptionKrishnamurthy, D., Harris, L.W., Levin, Y., Koutroukides, T.A., Rahmoune, H., Pietsch, S., Metabolic, hormonal and stress-related molecular changes in post-mortem pituitary glands from schizophrenia subjects (2012) World J Biol Psychiatry, , Jan 17
dc.descriptionWang, L., Lockstone, H.E., Guest, P.C., Levin, Y., Palotás, A., Pietsch, S., Expression profiling of fibroblasts identifies cell cycle abnormalities in schizophrenia (2010) J Proteome Res., 9, pp. 521-527
dc.descriptionLevin, Y., Wang, L., Schwarz, E., Koethe, D., Leweke, F.M., Bahn, S., Global proteomic profiling reveals altered proteomic signature in schizophrenia serum (2010) Mol Psychiatry., 15, pp. 1088-1100
dc.descriptionGuest, P.C., Wang, L., Harris, L.W., Burling, K., Levin, Y., Ernst, A., Increased levels of circulating insulin-related peptides in first-onset, antipsychotic naive schizophrenia patients (2010) Mol Psychiatry., 15, pp. 118-119
dc.descriptionGuest, P.C., Schwarz, E., Krishnamurthy, D., Harris, L.W., Leweke, F.M., Rothermundt, M., Altered levels of circulating insulin and other neuroendocrine hormones associated with the onset of schizophrenia (2011) Psychoneuroendocrinology., 36 (7), pp. 1092-1096
dc.descriptionMartins-de-Souza, D., Is the word "biomarker" being properly used by proteomics research in neuroscience? (2010) Eur Arch Psychiatry Clin Neurosci., 260, pp. 561-562
dc.descriptionBernstein, H.G., Steiner, J., Bogerts, B., Glial cells in schizophrenia: Pathophysiological significance and possible consequences for therapy (2009) Expert Rev Neurother., 9, pp. 1059-1071
dc.descriptionde Souza Martins, D., Oliveira, B.M., Castro-Dias, E., Winck, F.V., Horiuchi, R.S., Baldasso, P.A., The untiring search for the most complete proteome representation: Reviewing the methods (2008) Brief Funct Genomic Proteomic., 7, pp. 312-321
dc.descriptionMartins-de-Souza, D., Guest, P.C., Vanattou-Saifoudine, N., Harris, L.W., Bahn, S., Proteomic technologies for biomarker studies in psychiatry: Advances and needs (2011) Int Rev Neurobiol., 101, pp. 65-94
dc.descriptionLink, A.J., Eng, J., Schieltz, D.M., Carmack, E., Mize, G.J., Morris, D.R., Direct analysis of protein complexes using mass spectrometry (1999) Nat Biotechnol., 17, pp. 676-682
dc.descriptionGygi, S.P., Rist, B., Gerber, S.A., Turecek, F., Gelb, M.H., Aebersold, R., Quantitative analysis of complex protein mixtures using isotope-coded affinity tags (1999) Nat Biotechnol., 17, pp. 994-999
dc.languageen
dc.languagept
dc.publisher
dc.relationRevista de Psiquiatria Clinica
dc.rightsaberto
dc.sourceScopus
dc.titleLarge-scale Analyses Of Schizophrenia Proteome [análise Proteômica Da Esquizofrenia]
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución