e-Learning has been used in medical education and has changed markedly inresponse to technological advances in this field. To update the learning environment andadapt it to the ever-changing student profile, various multimedia technologies have beenintroduced into medical education to enhance student knowledge. Over the years, thesetechnologies have been variously referred to as computer-assisted learning, web-basedlearning, online learning, internet-based learning or, simply, e-Learning, although theseare not all necessarily interchangeable terms. These new types of media never replacedolder, more traditional methods of teaching but mingled with the latter to generate newforms that contain features from each of the original approaches. For the basic sciencedisciplines that form the basis of medical courses, it is important that the learning processoccur in the most efficient manner since students will not encounter many of thefundamental concepts directly, but will depend on them daily in clinical practice. Inmedical education, e-Learning can be used to provide extra-class activity thatsupplements formal class lectures by extrapolating traditional classroom boundaries andallowing students to focus on their individual needs, i.e., an individualized way oflearning. The use of e-Learning during class demands specific training and skills of theeducator, particularly an ability to interact easily with information and communicationtechnologies and to have a flexible mind that is open to innovate and adapt the classiclecture style to the needs of a new generation of students. As a counterpart, students areexpected to adapt to a new learning situation that requires them to share, discuss, explore and generally interact in a more collaborative manner. Our experience in e-Learningbegan at the turn of the century, in 2000, when we gradually began to introduceinformation and communication technologies into the teaching of Human Embryology tofirst year medical students at the State University of Campinas (UNICAMP), Brazil. Inthis chapter, we discuss our perceptions, as well as future plans on the possible use of e-Learning as a supplemental activity and as the main strategy for providing a trulycollaborative approach for learning in the classroom. e-Learning may help students moveaway from dependence on lecturers as the major or only strategy of learning to a moreautonomous or independent situation. 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