| dc.creator | Blotta M.H. | |
| dc.creator | DeKruyff R.H. | |
| dc.creator | Umetsu D.T. | |
| dc.date | 1997 | |
| dc.date | 2015-06-30T14:50:54Z | |
| dc.date | 2015-11-26T15:11:12Z | |
| dc.date | 2015-06-30T14:50:54Z | |
| dc.date | 2015-11-26T15:11:12Z | |
| dc.date.accessioned | 2018-03-28T22:21:18Z | |
| dc.date.available | 2018-03-28T22:21:18Z | |
| dc.identifier | | |
| dc.identifier | Journal Of Immunology. , v. 158, n. 12, p. 5589 - 5595, 1997. | |
| dc.identifier | 221767 | |
| dc.identifier | | |
| dc.identifier | http://www.scopus.com/inward/record.url?eid=2-s2.0-0031570475&partnerID=40&md5=c626b6068c96cc9e7e74092d8549d666 | |
| dc.identifier | http://www.repositorio.unicamp.br/handle/REPOSIP/100362 | |
| dc.identifier | http://repositorio.unicamp.br/jspui/handle/REPOSIP/100362 | |
| dc.identifier | 2-s2.0-0031570475 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1258078 | |
| dc.description | We examined the effects of corticosteroids on IL-12 production by human monocytes and on cytokine synthesis in T cells. To distinguish the effects of corticosteroids on the APC used to activate the T cell from direct effects of corticosteroids on the T cell, experiments were performed by exposing the APC and not the T cell to corticosteroids. We found that corticosteroids significantly inhibited the production in monocytes of IL-12, a cytokine that is extremely potent in enhancing IFN-γ and inhibiting IL-4 synthesis in T cells. We demonstrated that reduced production of IL-12 in corticosteroid-treated monocytes resulted in a decreased capacity of the monocytes to induce IFN-γ and an increased ability to induce IL-4 in T cells. These results suggest that although corticosteroids may be beneficial for the treatment of asthma or allergic disease due to direct inhibitory effects of corticosteroids on cytokine synthesis in T cells, chronic corticosteroid therapy may indirectly exacerbate the long-term course of allergic disease. This deleterious effect of corticosteroids would result from a limitation in IL-12 production in tissue monocytes and macrophages, which would enhance production of Th2 cytokines (which augment allergic disease), and would reduce production of Th1 cytokines (which attenuate allergic disease) in T cells that subsequently infiltrate the tissues. | |
| dc.description | 158 | |
| dc.description | 12 | |
| dc.description | 5589 | |
| dc.description | 5595 | |
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| dc.language | en | |
| dc.publisher | | |
| dc.relation | Journal of Immunology | |
| dc.rights | fechado | |
| dc.source | Scopus | |
| dc.title | Corticosteroids Inhibit Il-12 Production In Human Monocytes And Enhance Their Capacity To Induce Il-4 Synthesis In Cd4+ Lymphocytes | |
| dc.type | Artículos de revistas | |
