Influence Of Hypnotics On Cisatracurium-induced Neuromuscular Block. Use Of Acceleromyograhpy

dc.creatorDe Assuncao Braga A.D.F.
dc.creatorSilva Braga F.S.D.
dc.creatorBraga Poterio G.M.
dc.creatorFachini Frias J.A.
dc.creatorSilva Pedro F.M.
dc.creatorMunhoz D.C.
dc.date2013
dc.date2015-06-25T19:12:04Z
dc.date2015-11-26T15:09:22Z
dc.date2015-06-25T19:12:04Z
dc.date2015-11-26T15:09:22Z
dc.date.accessioned2018-03-28T22:19:34Z
dc.date.available2018-03-28T22:19:34Z
dc.identifier
dc.identifierRevista Brasileira De Anestesiologia. , v. 63, n. 3, p. 249 - 253, 2013.
dc.identifier347094
dc.identifier10.1016/S0034-7094(13)70225-3
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84877979400&partnerID=40&md5=48535c0c0452feae66e664f67ce488e5
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/88693
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/88693
dc.identifier2-s2.0-84877979400
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1257803
dc.descriptionBackground and objective: Different drugs, including hypnotics, may influence the pharmacodynamic effects of neuromuscular blockers (NMB). The aim of this study was to evaluate the influence of propofol and etomidate on cisatracurium-induced neuromuscular blockade. Method: We included 60 patients, ASA I and II, undergoing elective surgery under general anesthesia in the study and randomly allocated them into two groups, according to their hypnotic drug: GI (propofol) and GII (etomidate). Patients received intramuscular (IM) midazolam (0.1mg.kg-1) as premedication and we performed induction with propofol (2.5mg.kg-1) or etomidate (0.3mg.kg1), preceded by fentanyl (250mg) and followed by cisatracurium (0.1mg.kg-1). The patients were ventilated with 100% oxygen until obtaining a reduction of 95% or more in the adductor pollicis response amplitude, with subsequent laryngoscopy and tracheal intubation. Neuromuscular function was monitored by acceleromyograhpy. We evaluated the onset of action of cisatracurium, tracheal intubation conditions, and hemodynamic repercussions. Results: The mean time and standard deviations of cisatracurium onset were: GI (86.6. ±. 14.3. s) and GII (116.9. ±. 11.6. s), with a significant difference (p. <. 0, 0001). Intubation conditions were acceptable in 100% of GI and 53.3% of GII patients (p. <. 0.0001). Conclusion: Induction of neuromuscular blockade with cisatracurium was faster, with better intubation conditions in patients receiving propofol compared to those receiving etomidate, without hemodynamic repercussions. © 2013 Elsevier Editora Ltda.
dc.description63
dc.description3
dc.description249
dc.description253
dc.descriptionFuchs-Buder, T., Claudius, C., Skovgaard, L.T., Good clinical research practice in pharmacodynamic studies of neuromuscular blocking agents II: the Stockholm revision (2007) Acta Anaesthesiol Scand, 51, pp. 789-808
dc.descriptionViby-Mogensen, J., Engbaek, J., Eriksson, L.I., Good clinical research practice (GCRP) in pharmacodynamic studies of neuromuscular blocking agents (1996) Acta Anaesthesiol Scand, 40, pp. 59-74
dc.descriptionViby-Mogensen, J., Ostergaard, D., Donati, F., Pharmacokinetic studies of neuromuscular blocking agents: good clinical research practice (GCRP) (2000) Acta Anaesthesiol Scand, 44, pp. 1169-1190
dc.descriptionMuir, A.W., Anderson, K.A., POW, E., Interaction between rocuronium bromide and some drugs, used during anaesthesia (1994) Eur J Anaesthesiol, 11 (SUPPL 9), pp. 93-98
dc.descriptionGill, R.S., Scott, R.P.F., Etomidate short the onset time of neuromuscular block (1992) Br J Anaesth, 69, pp. 444-446
dc.descriptionDilger, J.P., Liu, Y., Vidal, A.M., Interactions of general anaesthetics with single acetylcholine receptor channels (1995) Eur J Anaesthesiol, 12, pp. 31-39
dc.descriptionAbdel-Zaher, A.O., Askar, F.G., The myoneural effects of propofol emulsion (Diprivan) on the nerve-muscle preparations of rats (1997) Pharmacol Res, 36 (4), pp. 323-332
dc.descriptionBraga, A.F.A., Braga, F.S.B., Potério, G.M.B., The effect of different doses of propofol on tracheal intubating conditions without muscle relaxant in children (2001) Eur J Anaesthesiol, 18, pp. 384-388
dc.descriptionSavarese, J.J., Lien, C.A., Belmont, M.R., The clinical pharmacology of new benzylisoquinoline-diester compounds, with special consideration of cisatracurium and mivacurium (1997) Anaesthesist, 46, pp. 840-849
dc.descriptionMunhoz, D.C., Braga, A.F.A., Potério, G.M.B., Influência do propofol e do etomidato no bloqueio neuromuscular produzido pelo rocurônio Avaliação pela aceleromiografia (2002) Rev Bras Anestesiol, 52, pp. 673-680
dc.descriptionBluestein, L.S., Stinson, L.W., Lennon, R.L., Evaluation of cisatracurium, a new neuromuscular blocking agent, for tracheal intubation (1996) Can J Anaesth, 43, pp. 925-931
dc.descriptionKirov, K., Motamed, C., Decailliot, F., Comparison of the neuromuscular blocking effect of cisatracurium and atracurium on the larynx and adductor pollicis (2004) Acta Anaesthesiol Scand, 48, pp. 577-581
dc.descriptionTaha, S.K., Siddik-Sayyid, S.M., Alameddine, M., Propofol is superior to thiopental for intubation without muscle relaxants (2005) Can J Anaesth, 52, pp. 249-253
dc.descriptionErhan, E., Ugur, G., Gunusen, I., Propofol - not thiopental or etomidate - with remifentanil provides adequate intubating conditions in the absence of neuromuscular blockade (2003) Can J Anaesth, 50, pp. 108-115
dc.descriptionBarker, P., Langton, J.A., Wilson, I.G., Movements of the vocal cords on induction of anaesthesia with thiopentone or propofol (1992) Br J Anaesth, 69, pp. 23-25
dc.descriptionBrown, G.W., Patel, Ellis, F.R., Comparison of propofol and thiopentone for laryngeal mask insertion (1991) Anaesthesia, 46, pp. 771-772
dc.descriptionKallar, M.D., Propofol allows intubation without relaxants (1990) Anesthesiology, 73, pp. A21
dc.descriptionWoods, A.W., Allam, S., Tracheal intubation without the use neuromuscular blocking agents (2005) Br J Anaesth, 94, pp. 151-158
dc.descriptionSneyd, R., O' Sullivan, E., Tracheal intubation without neuromuscular blocking agents: is there any point? (2010) Br J Anaesth, 104, pp. 535-537
dc.descriptionSiddik-Sayyid, S.M., Taha, S.K., Aouad, M.T., Propofol 2m/kg is superior to propofol 2mg/kg for tracheal intubation in children during sevoflurane induction (2011) Acta Anaesthesiol Scand, 55, pp. 535-538
dc.descriptionDe Mey, J.C., De Baerdemaeker, L., De Laat, M., The onset of neuromuscular block at the masseter muscle as a predictor of optimal intubating conditions with rocuronium (1999) Eur J Anaesthesiol, 16, pp. 387-389
dc.descriptionBraga Ade, F., Munoz, D.C., Braga, F.S., Influence of stimulus frequency on blockade induced by pancuronium and rocuronium: study on rats phrenic nerve-diaphragm preparation (2007) Acta Cir Bras, 22, pp. 446-450
dc.descriptionCurran, M.J., Donati, F., Bevan, D.R., Onset and recovery of atracurium and suxamethonium - induced neuromuscular blockade with simultaneous train-of-four and single twitch stimulation (1987) Br J Anaesth, 59, pp. 989-994
dc.descriptionGirling, K.J., Mahajan, R.P., The effect of stabilization on the onset of neuromuscular block when assessed using accelerometry (1996) Anesth Analg, 82, pp. 1257-1260
dc.descriptionMcCoy, E.P., Mirakhur, R.K., Maddineni, V.R., Pharmacokinetics of rocuronium after bolus and continuous infusion during halothane anaesthesia (1995) Br J Anaesth, 76, pp. 29-33
dc.descriptionSaxena, P.R., Dhasmana, K.M., Prakash, O., A comparison of systemic and regional haemodynamic effects of d-tubocurarine, pancuronium. and vecuronium (1983) Anesthesiology, 59, pp. 102-108
dc.descriptionScott, R.P.F., Savarese, J.J., Basta, S.J., Clinical pharmacology of atracurium given high dose (1986) Br J Anaesth, 58, pp. 834-838
dc.descriptionTullock, W.C., Diana, P., Cook, D.R., Neuromuscular and cardiovascular effects of high-dose vecuronium (1990) Anesth Analg, 70, pp. 86-90
dc.descriptionAun, C.S.T., Sung, R.Y.T., O'Meara, M.E., Cardiovascular effects of intravenous induction in children: comparison between propofol and thiopentone (1993) Br J Anaesth, 70, pp. 647-653
dc.descriptionFuchs-Buder, T., Claudius, C., Skovgaard, L.T., Good clinical research practice in pharmacodynamic studies of neuromuscular blocking agents II: the Stockholm revision (2007) Acta Anaesthesiol Scand, 51, pp. 789-808
dc.descriptionViby-Mogensen, J., Engbaek, J., Eriksson, L.I., Good clinical research practice (GCRP) in pharmacodynamic studies of neuromuscular blocking agents (1996) Acta Anaesthesiol Scand, 40, pp. 59-74
dc.descriptionViby-Mogensen, J., Ostergaard, D., Donati, F., Pharmacokinetic studies of neuromuscular blocking agents: good clinical research practice (GCRP) (2000) Acta Anaesthesiol Scand, 44, pp. 1169-1190
dc.descriptionMuir, A.W., Anderson, K.A., POW, E., Interaction between rocuronium bromide and some drugs, used during anaesthesia (1994) Eur J Anaesthesiol, 11 (SUPPL 9), pp. 93-98
dc.descriptionGill, R.S., Scott, R.P.F., Etomidate short the onset time of neuromuscular block (1992) Br J Anaesth, 69, pp. 444-446
dc.descriptionDilger, J.P., Liu, Y., Vidal, A.M., Interactions of general anaesthetics with single acetylcholine receptor channels (1995) Eur J Anaesthesiol, 12, pp. 31-39
dc.descriptionAbdel-Zaher, A.O., Askar, F.G., The myoneural effects of propofol emulsion (Diprivan) on the nerve-muscle preparations of rats (1997) Pharmacol Res, 36 (4), pp. 323-332
dc.descriptionBraga, A.F.A., Braga, F.S.B., Potério, G.M.B., The effect of different doses of propofol on tracheal intubating conditions without muscle relaxant in children (2001) Eur J Anaesthesiol, 18, pp. 384-388
dc.descriptionSavarese, J.J., Lien, C.A., Belmont, M.R., The clinical pharmacology of new benzylisoquinoline-diester compounds, with special consideration of cisatracurium and mivacurium (1997) Anaesthesist, 46, pp. 840-849
dc.descriptionMunhoz, D.C., Braga, A.F.A., Potério, G.M.B., Influência do propofol e do etomidato no bloqueio neuromuscular produzido pelo rocurônio Avaliação pela aceleromiografia (2002) Rev Bras Anestesiol, 52, pp. 673-680
dc.descriptionBluestein, L.S., Stinson, L.W., Lennon, R.L., Evaluation of cisatracurium, a new neuromuscular blocking agent, for tracheal intubation (1996) Can J Anaesth, 43, pp. 925-931
dc.descriptionKirov, K., Motamed, C., Decailliot, F., Comparison of the neuromuscular blocking effect of cisatracurium and atracurium on the larynx and adductor pollicis (2004) Acta Anaesthesiol Scand, 48, pp. 577-581
dc.descriptionTaha, S.K., Siddik-Sayyid, S.M., Alameddine, M., Propofol is superior to thiopental for intubation without muscle relaxants (2005) Can J Anaesth, 52, pp. 249-253
dc.descriptionErhan, E., Ugur, G., Gunusen, I., Propofol - not thiopental or etomidate - with remifentanil provides adequate intubating conditions in the absence of neuromuscular blockade (2003) Can J Anaesth, 50, pp. 108-115
dc.descriptionBarker, P., Langton, J.A., Wilson, I.G., Movements of the vocal cords on induction of anaesthesia with thiopentone or propofol (1992) Br J Anaesth, 69, pp. 23-25
dc.descriptionBrown, G.W., Patel, Ellis, F.R., Comparison of propofol and thiopentone for laryngeal mask insertion (1991) Anaesthesia, 46, pp. 771-772
dc.descriptionKallar, M.D., Propofol allows intubation without relaxants (1990) Anesthesiology, 73, pp. A21
dc.descriptionWoods, A.W., Allam, S., Tracheal intubation without the use neuromuscular blocking agents (2005) Br J Anaesth, 94, pp. 151-158
dc.descriptionSneyd, R., O' Sullivan, E., Tracheal intubation without neuromuscular blocking agents: is there any point? (2010) Br J Anaesth, 104, pp. 535-537
dc.descriptionSiddik-Sayyid, S.M., Taha, S.K., Aouad, M.T., Propofol 2m/kg is superior to propofol 2mg/kg for tracheal intubation in children during sevoflurane induction (2011) Acta Anaesthesiol Scand, 55, pp. 535-538
dc.descriptionDe Mey, J.C., De Baerdemaeker, L., De Laat, M., The onset of neuromuscular block at the masseter muscle as a predictor of optimal intubating conditions with rocuronium (1999) Eur J Anaesthesiol, 16, pp. 387-389
dc.descriptionBraga Ade, F., Munoz, D.C., Braga, F.S., Influence of stimulus frequency on blockade induced by pancuronium and rocuronium: study on rats phrenic nerve-diaphragm preparation (2007) Acta Cir Bras, 22, pp. 446-450
dc.descriptionCurran, M.J., Donati, F., Bevan, D.R., Onset and recovery of atracurium and suxamethonium - induced neuromuscular blockade with simultaneous train-of-four and single twitch stimulation (1987) Br J Anaesth, 59, pp. 989-994
dc.descriptionGirling, K.J., Mahajan, R.P., The effect of stabilization on the onset of neuromuscular block when assessed using accelerometry (1996) Anesth Analg, 82, pp. 1257-1260
dc.descriptionMcCoy, E.P., Mirakhur, R.K., Maddineni, V.R., Pharmacokinetics of rocuronium after bolus and continuous infusion during halothane anaesthesia (1995) Br J Anaesth, 76, pp. 29-33
dc.descriptionSaxena, P.R., Dhasmana, K.M., Prakash, O., A comparison of systemic and regional haemodynamic effects of d-tubocurarine, pancuronium. and vecuronium (1983) Anesthesiology, 59, pp. 102-108
dc.descriptionScott, R.P.F., Savarese, J.J., Basta, S.J., Clinical pharmacology of atracurium given high dose (1986) Br J Anaesth, 58, pp. 834-838
dc.descriptionTullock, W.C., Diana, P., Cook, D.R., Neuromuscular and cardiovascular effects of high-dose vecuronium (1990) Anesth Analg, 70, pp. 86-90
dc.descriptionAun, C.S.T., Sung, R.Y.T., O'Meara, M.E., Cardiovascular effects of intravenous induction in children: comparison between propofol and thiopentone (1993) Br J Anaesth, 70, pp. 647-653
dc.languageen
dc.publisher
dc.relationRevista Brasileira de Anestesiologia
dc.rightsfechado
dc.sourceScopus
dc.titleInfluence Of Hypnotics On Cisatracurium-induced Neuromuscular Block. Use Of Acceleromyograhpy
dc.typeArtículos de revistas


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