Brasil | Artículos de revistas
dc.creatorZago V.H.S.
dc.creatordos Santos J.E.T.
dc.creatorDanelon M.R.G.
dc.creatorda Silva R.M.M.
dc.creatorPanzoldo N.B.
dc.creatorParra E.S.
dc.creatorAlexandre F.
dc.creatorVirginio V.W.M.
dc.creatorQuintao E.C.R.
dc.creatorde Faria E.C.
dc.date2013
dc.date2015-06-25T19:12:00Z
dc.date2015-11-26T15:09:20Z
dc.date2015-06-25T19:12:00Z
dc.date2015-11-26T15:09:20Z
dc.date.accessioned2018-03-28T22:19:32Z
dc.date.available2018-03-28T22:19:32Z
dc.identifier
dc.identifierArquivos Brasileiros De Cardiologia. , v. 100, n. 1, p. 14 - 20, 2013.
dc.identifier0066782X
dc.identifier10.1590/S0066-782X2012005000120
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84873443306&partnerID=40&md5=ef421d8a64cad646019de449d0980a11
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/88682
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/88682
dc.identifier2-s2.0-84873443306
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1257796
dc.descriptionBackground: Endothelial nitric oxide synthase (eNOS) activity may be modulated by high-density lipoprotein cholesterol (HDL-C), statins or polymorphisms, such as the T-786C of eNOS. Objective: This study aimed at evaluating if the T-786C polymorphism is associated with changes of atorvastatin effects on the lipid profile, on the concentrations of metabolites of nitric oxide (NO) and of high sensitivity C-reactive protein (hsCRP). Methods: Thirty male volunteers, asymptomatic, aged between 18 and 56 years were genotyped and classified according to absence (TT, n = 15) or presence (CC, n = 15) of the polymorphism. They were randomly selected for the use of placebo or atorvastatin (10 mg/day/14 days). After each treatment lipids, lipoproteins, HDL2 and HDL3 composition, cholesteryl ester transfer protein (CETP) activity, metabolites of NO and hsCRP were evaluated. Results: The comparisons between genotypes after placebo showed an increase in CETP activity in a polymorphism-dependent way (TT, 12±7; CC, 22±12; p ≤ 0.05). The interaction analyses between treatments indicated that atorvastatin has an effect on cholesterol, LDL, nitrite and lipid-protein ratios (HDL2 and HDL3) (p ≤ 0.001) in both genotypes. Interestingly, we observed genotype/drug interactions on CETP (p ≤ 0.07) and lipoprotein (a) (Lp(a)) (p ≤ 0.056), leading to a borderline decrease in CETP, but with no effect on Lp(a). HsCRP showed no alteration. Conclusion: These results suggest that statin treatment may be relevant for primary prevention of atherosclerosis in patients with the T-786C polymorphism of eNOS, considering the effects on lipid metabolism.
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dc.languageen
dc.publisher
dc.relationArquivos Brasileiros de Cardiologia
dc.rightsaberto
dc.sourceScopus
dc.titleEffects Of Atorvastatin And T-786c Polymorphism Of Enos Gene On Plasma Metabolic Lipid Parameters
dc.typeArtículos de revistas


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