In Vitro Antiviral Activity Of Seeds From Guettarda Angelica Against Avian Viruses

dc.creatorBarros A.V.
dc.creatorDa Conceicao A.O.
dc.creatorSimoni I.C.
dc.creatorPadilla M.A.
dc.creatorFernandes M.J.B.
dc.creatorArns C.W.
dc.date2013
dc.date2015-06-25T19:11:09Z
dc.date2015-11-26T15:08:38Z
dc.date2015-06-25T19:11:09Z
dc.date2015-11-26T15:08:38Z
dc.date.accessioned2018-03-28T22:18:59Z
dc.date.available2018-03-28T22:18:59Z
dc.identifier
dc.identifierJournal Of Applied Pharmaceutical Science. , v. 3, n. 7, p. 31 - 33, 2013.
dc.identifier22313354
dc.identifier10.7324/JAPS.2013.3706
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84882737382&partnerID=40&md5=657ad4d8437ca0b25f88966b8bbdd6ff
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/88611
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/88611
dc.identifier2-s2.0-84882737382
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1257705
dc.descriptionThe aim of this study was to evaluate the inhibition of the aqueous extract of seeds (AEs) from Guettarda angelica on cell infection by two avian RNA viruses: avian reovirus (ARV) and metapneumovirus (AMPV). The cytotoxic and antiviral activities were evaluated by MTT assay to determine the 50% cytotoxic (CC50) and inhibitory concentrations (IC50). The selectivity index (SI=CC50/IC50) also carried out. AEs exhibited antiviral activity only against ARV presenting IC50 of 23.59g/mL. This inhibition was not due to any cytotoxic effect of AEs since the CC50 on Vero cells was of 400.60g/μL and its SI was of 17.00; this extract also showed a virucidal effect on ARV. Previous studies also demonstrated antiviral activity of AEs extract against three animal herpesviruses. Thus, the seeds from G. angelica showing antiviral activity against DNA and RNA viruses, enveloped and non-enveloped, could be promising source of new antiviral agents encouraging its fractionation to isolate the active compound.
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dc.description7
dc.description31
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dc.languageen
dc.publisher
dc.relationJournal of Applied Pharmaceutical Science
dc.rightsfechado
dc.sourceScopus
dc.titleIn Vitro Antiviral Activity Of Seeds From Guettarda Angelica Against Avian Viruses
dc.typeArtículos de revistas


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